Article
Pharmacology & Pharmacy
Faiza Naimat, Mathumalar Loganathan Fahrni, Shankar Purushothaman, Mohamad Nizam Abdul Ghani, Supatat Chumnumwat, Zaheer-Ud-Din Babar
Summary: Community pharmacists are receptive to and value precision medicine. A relatively high number of pharmacists have been exposed to the concept of precision medicine through their pharmacy education and are willing to adopt it in their daily practice. With appropriate training and education, community pharmacists will be prepared to provide precision medicine services in the future.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Anders Edsjo, Louise Holmquist, Birgit Geoerger, Frederique Nowak, Georgy Gomon, Catherine Alix-Panabieres, Carolin Ploeger, Ulrik Lassen, Christophe Le Tourneau, Janne Lehtio, Patrick A. Ott, Andreas von Deimling, Stefan Froehling, Emile Voest, Frederick Klauschen, Rodrigo Dienstmann, Aisha Alshibany, Lillian L. Siu, Albrecht Stenzinger
Summary: Precision cancer medicine requires the involvement and commitment of many stakeholders and can be improved through advancements in molecular diagnostics and clinical trial concepts. Adaptive profiling strategies and early detection approaches are becoming routine in patient management. Collaborative efforts and multicentric networks are crucial in implementing precision oncology in practice.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jianzhen Lin, Yinghao Cao, Xu Yang, Guangyu Li, Yang Shi, Dongxu Wang, Junyu Long, Yang Song, Jinzhu Mao, Fucun Xie, Yi Bai, Lei Zhang, Xiaobo Yang, Xueshuai Wan, Anqiang Wang, Mei Guan, Lin Zhao, Ke Hu, Jie Pan, Li Huo, Xin Lu, Yilei Mao, Xinting Sang, Henghui Zhang, Kai Wang, Xiaoyue Wang, Haitao Zhao
Summary: The study revealed extensive genomic diversity and heterogeneity among biliary tract carcinoma (BTC) patients, with different gene mutations having varying impacts on patient prognosis. Personalized targeted therapies showed significant efficacy in patients with potentially actionable targets, providing a basis for further clinical trials.
Article
Oncology
Joanne Lundy, Marion Harris, John Zalcberg, Allan Zimet, David Goldstein, Val Gebski, Adina Borsaru, Christopher Desmond, Michael Swan, Brendan J. Jenkins, Daniel Croagh
Summary: This study demonstrated the feasibility of molecular screening for targeted therapies in pancreatic cancer patients, using diagnostic EUS-FNA biopsies as a reliable source of tumor material. Although single agent panitumumab was safe and tolerable, it did not lead to objective tumor responses in the KRAS wild-type PDAC patients studied.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pathology
Jerald P. Radich, Edward Briercheck, Daniel T. Chiu, Manoj P. Menon, Olga Sala Torra, Cecilia C. S. Yeung, Edus H. Warren
Summary: Most cancer cases occur in LMICs where the necessary infrastructure for optimal cancer care is lacking. However, examples of novel partnerships and creative solutions suggest that with determination, creativity, persistence, and some luck, precision medicine may be possible in these countries.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
(2022)
Review
Medicine, General & Internal
Zhenxiao Wang, Hanjiao Qin, Shui Liu, Jiyao Sheng, Xuewen Zhang
Summary: Hepatocellular carcinoma (HCC) is the most common primary hepatocellular carcinoma (PHC), and early diagnosis is crucial for better prognosis. Recent advancements in precision medicine and understanding the biological mechanisms of HCC have led to the development of new diagnostic methods, such as emerging serum markers, liquid biopsies, molecular diagnosis, and improvements in imaging techniques. This review aims to summarize and analyze these scientific advances in early HCC diagnosis and discuss their application and limitations, providing a reference for further research and clinical practice.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Elena Sultova, C. Benedikt Westphalen, Andreas Jung, Joerg Kumbrink, Thomas Kirchner, Doris Mayr, Martina Rudelius, Steffen Ormanns, Volker Heinemann, Klaus H. Metzeler, Philipp A. Greif, Anna Hester, Sven Mahner, Nadia Harbeck, Rachel Wuerstlein
Summary: The establishment of a Molecular Tumor Board to provide personalized treatment recommendations based on molecular diagnostics has shown to be beneficial for metastatic breast cancer patients, with a high percentage of tumors having actionable genetic alterations and a significant number of patients experiencing clinical benefit from targeted therapies recommended by the board.
Article
Multidisciplinary Sciences
Tomohiko Ishikawa, Takenori Ogawa, Masahiro Shiihara, Hajime Usubuchi, Yuko Omori, Katsuya Hirose, Taito Itoh, Takuya Yoshida, Ayako Nakanome, Akira Okoshi, Kenjiro Higashi, Ryo Ishii, Masahiro Rokugo, Shun Wakamori, Yasunobu Okamura, Kengo Kinoshita, Yukio Katori, Toru Furukawa
Summary: This study established a translational model for testing the impact of molecular-targeted therapies on salivary gland cancers (SGCs) by combining patient-derived organoids and genomic analyses. The results showed that organoids retained most histopathological and genetic profiles of the original tumors and were valuable for testing genotype-oriented molecular-targeted therapy.
Article
Medicine, Research & Experimental
Aslaug Helland, Hege G. Russnes, Gro Live Fagereng, Khalid Al-Shibli, Yvonne Andersson, Thomas Berg, Line Bjorge, Egil Blix, Bodil Bjerkehagen, Sigmund Brabrand, Marte Gronlie Cameron, Astrid Dalhaug, Dalia Dietzel, Tom Donnem, Espen Enerly, Asmund Flobak, Sverre Fluge, Bjornar Gilje, Bjorn Tore Gjertsen, Bjorn Henning Gronberg, Kari Gronas, Tormod Guren, Hanne Hamre, Ase Haug, Daniel Heinrich, Geir Olav Hjortland, Eivind Hovig, Randi Hovland, Ann-Charlotte Iversen, Emiel Janssen, Jon Amund Kyte, Hedda von der Lippe Gythfeldt, Ragnhild Lothe, Jo-Asmund Lund, Leonardo Meza-Zepeda, Monica Cheng Munthe-Kaas, Olav Toai Duc Nguyen, Pitt Niehusmann, Hilde Katarina NilsenPuco, Anne Hansen Ree, Tonje Boyum Riste, Karin Semb, Eli Sihn Samdal Steinskog, Andreas Stensvold, Pal Suhrke, Oyvind Tennoe, Geir E. Tjonnfjord, Liv Jorunn Vassbotn, Eline Aas, Kristine Aasebo, Kjetil Tasken, Sigbjorn Smeland
Summary: Personalized cancer care based on tumour molecular characteristics has revolutionized treatment approaches and brought hope to many patients. The implementation of emerging technologies in molecular diagnostics, publicly funded in Norway, allows for comprehensive genomic profiling of tumours, offering more cancer patients the possibility of receiving precision cancer drugs through the national infrastructure called IMPRESS-Norway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Engineering, Chemical
Nader I. Al-Dewik, Salma N. Younes, Musthafa Mohamed Essa, Surajit Pathak, M. Walid Qoronfleh
Summary: Translational medicine plays a vital role in improving treatment strategies and patient outcomes, with biomarkers being an important component in clinical applications. However, the clinical validation of biomarkers remains challenging, widening the gap between research and application.
Article
Oncology
Larry Mansouri, Birna Thorvaldsdottir, Stamatia Laidou, Kostas Stamatopoulos, Richard Rosenquist
Summary: Genetics plays a crucial role in the clinical diagnostics of lymphomas, helping to subclassify the disease and stratify patient risk. Recent advancements in high-throughput sequencing technologies have provided a detailed understanding of the genomic landscape of various lymphoma entities, revealing a diverse genetic background. These studies have improved our understanding of lymphoma ontogeny and evolution and have identified potential genetic markers that can enhance lymphoma diagnostics and prognostication. However, the number of gene mutations with predictive impact for treatment selection remains limited. This review highlights clinically relevant diagnostic, prognostic, and predictive markers in lymphomas and discusses the potential of comprehensive genomic characterization for precision diagnostics and tailored therapy strategies.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jorge Postigo-Fernandez, Rebuma Firdessa-Fite, Remi J. Creusota
Summary: Antigen-specific immunotherapy using tailored epitopes delivered through proteins, peptides, or nucleic acids can reestablish tolerance and potentially provide precision medicine approach for treating tissue-specific autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Oncology
Yajing Liu, Yanbing Zhou, Pu Chen
Summary: Lung cancer is a highly prevalent and deadly malignancy that requires personalized treatment strategies. Lung cancer organoids (LCOs) have the potential to faithfully replicate tumor characteristics and heterogeneity, providing a promising platform for anti-tumor drug discovery. Additionally, LCOs can enhance current precision medicine for lung cancer and overcome the limitations of current approaches.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Sophie Katzendobler, Anna Do, Jonathan Weller, Mario M. Dorostkar, Nathalie L. Albert, Robert Forbrig, Maximilian Niyazi, Rupert Egensperger, Niklas Thon, Joerg Christian Tonn, Stefanie Quach
Summary: This retrospective study analyzed the diagnostic yield and safety of a standardized biopsy technique. The results showed that image-guided stereotactic serial biopsy enables reliable histopathological and molecular diagnoses with a very low complication rate. It is a valuable tool for precision medicine in patients with glioma who do not undergo microsurgical resection.
FRONTIERS IN NEUROLOGY
(2022)
Review
Immunology
Sydney Stanley, Qingyun Liu, Sarah M. Fortune
Summary: In the face of the global burden of tuberculosis, antibiotics remain effective tools to save lives and control the spread of Mycobacterium tuberculosis. The increasing availability of bacterial genomic data provides an opportunity to integrate genetic determinants of antibiotic response into treatment algorithms, advancing precision medicine approaches in TB treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Serena Mancarella, Valentina Greco, Francesca Baldassarre, Daniele Vergara, Michele Maffia, Stefano Leporatti
MACROMOLECULAR BIOSCIENCE
(2015)
Article
Gastroenterology & Hepatology
Amalia Azzariti, Serena Mancarella, Letizia Porcelli, Anna Elisa Quatrale, Alessandra Caligiuri, Luigi Lupo, Francesco Dituri, Gianluigi Giannelli
Meeting Abstract
Gastroenterology & Hepatology
C. Buccoliero, D. Consolante, F. Dituri, S. Mancarella, N. Hanafy, A. Mancinelli, P. Trerotoli, S. Leporatti, C. Pisano, G. Giannelli
JOURNAL OF HEPATOLOGY
(2016)
Meeting Abstract
Gastroenterology & Hepatology
F. Dituri, S. Mancarella, C. Buccoliero, L. Lupo, G. Giannelli
JOURNAL OF HEPATOLOGY
(2016)
Article
Cell Biology
Yuan Cao, Rahul Agarwal, Francesco Dituri, Luigi Lupo, Paolo Trerotoli, Serena Mancarella, Peter Winter, Gianluigi Giannelli
CELL DEATH & DISEASE
(2017)
Review
Biochemistry & Molecular Biology
Laia Caja, Francesco Dituri, Serena Mancarella, Daniel Caballero-Diaz, Aristidis Moustakas, Gianluigi Giannelli, Isabel Fabregat
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Cell Biology
Bhavna Rani, Andrea Malfettone, Francesco Dituri, Jitka Soukupova, Luigi Lupo, Serena Mancarella, Isabel Fabregat, Gianluigi Giannelli
CELL DEATH & DISEASE
(2018)
Article
Chemistry, Physical
Loretta Laureana del Mercato, Marzia Maria Ferraro, Francesca Baldassarre, Serena Mancarella, Valentina Greco, Ross Rinaldi, Stefano Leporatti
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2014)
Article
Oncology
Teresa Maria Elisa Modica, Francesco Dituri, Serena Mancarella, Claudio Pisano, Isabel Fabregat, Gianluigi Giannelli
Review
Oncology
Serena Mancarella, Silke Krol, Alberto Crovace, Stefano Leporatti, Francesco Dituri, Martina Frusciante, Gianluigi Giannelli
Article
Biochemistry & Molecular Biology
Serena Mancarella, Grazia Serino, Sergio Coletta, Raffaele Armentano, Francesco Dituri, Francesco Ardito, Andrea Ruzzenente, Isabel Fabregat, Gianluigi Giannelli
Summary: The study demonstrates that Crenigacestat effectively inhibits NOTCH1 and HES1, while not affecting tumor progression. The drug also triggers a strong immune response and blocks neovascularization in the tumor ecosystem without affecting fibrotic reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Francesco Dituri, Gianluigi Gigante, Rosanna Scialpi, Serena Mancarella, Isabel Fabregat, Gianluigi Giannelli
Summary: Proteoglycans play important roles in the progression of solid tumors, such as HCC, and can be used as therapeutic targets or agents. Some proteoglycans promote the growth and angiogenesis of HCC cells, while others inhibit cancer neovascularization and enhance drug sensitivity. Interventional strategies involving humanized monoclonal antibodies, engineered T cells, or recombinant proteins mimicking the effects of proteoglycans are potential treatments for HCC.
Meeting Abstract
Medicine, General & Internal
S. Mancarella, F. Dituri, A. Azzariti, L. Porcelli, A. E. Quatrale, G. Giannelli
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2016)