HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators

Mutations and mechanisms in congenital and age-related cataracts

(2017) Alan Shiels et al.   EXPERIMENTAL EYE RESEARCH

Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening

(2016) Baobing Zhao et al.   DEVELOPMENTAL CELL

Heat shock factor 4 regulates lens epithelial cell homeostasis by working with lysosome and anti-apoptosis pathways

(2016) Xiukun Cui et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53

(2015) Mi Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Tumor Suppressor, p53 Regulates the γA-Crystallin Gene During Mouse Lens Development

(2014) X.-H. Hu et al.   CURRENT MOLECULAR MEDICINE

HSF4 Mutation p.Arg116His Found in Age-Related Cataracts and in Normal Populations Produces Childhood Lamellar Cataract in Transgenic Mice

(2014) Zhe Jing et al.   HUMAN MUTATION

p53 Directly Regulates αA- and βA3/A1-Crystallin Genes to Modulate Lens Differentiation

(2013) W.-K. Ji et al.   CURRENT MOLECULAR MEDICINE

Zebrafish HSF4: a novel protein that shares features of both HSF1 and HSF4 of mammals

(2012) Cynthia L. Swan et al.   CELL STRESS & CHAPERONES

The p53-Bak Apoptotic Signaling Axis Plays an Essential Role in Regulating Differentiation of the Ocular Lens

(2012) M. Deng et al.   CURRENT MOLECULAR MEDICINE

The Tumor Suppressor p53 Regulates c-Maf and Prox-1 to Control Lens Differentiation

(2012) F. -Y. Liu et al.   CURRENT MOLECULAR MEDICINE

αA- and αB-Crystallins Interact with Caspase-3 and Bax to Guard Mouse Lens Development

(2012) W.-F. Hu et al.   CURRENT MOLECULAR MEDICINE

TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction

(2012) Erin L. Doyle et al.   NUCLEIC ACIDS RESEARCH

The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens

(2011) L. A. Wiley et al.   Disease Models & Mechanisms

SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell

(2010) Li Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lens Fiber Cell Differentiation and Denucleation Are Disrupted through Expression of the N-Terminal Nuclear Receptor Box of Ncoa6 and Result in p53-dependent and p53-independent Apoptosis

(2010) Wei-Lin Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Removal of Hsf4 leads to cataract development in mice through down-regulation of γS-crystallin and Bfsp expression

(2009) Xiaohe Shi et al.   BMC MOLECULAR BIOLOGY

αB-crystallin: A novel p53-target gene required for p53-dependent apoptosis

(2009) Gou Watanabe et al.   CANCER SCIENCE

Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development

(2009) Jenny C. Geatrell et al.   EXPERIMENTAL EYE RESEARCH

Extensive apoptosis and abnormal morphogenesis in pro-caspase-3 transgenic zebrafish during development

(2008) M. Yamashita et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Congenital cataracts and their molecular genetics

(2007) J. Fielding Hejtmancik   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY