Article
Cell Biology
Yanming Yu, Daoxu Wu, Yongwei Li, Hui Qiao, Zhengfei Shan
Summary: Ketamine-induced cystitis results in bladder hyperactivity and injury by activating autophagy, apoptosis, and endoplasmic reticulum stress-related markers. Salubrinal can reverse the effects of ketamine on complex formation and related markers. Transfection with shIRE1 can offset the effects of ketamine on cells.
Article
Environmental Sciences
Lin Zhao, Liyuan Wang, Han Wang, Tao Xi, Sijia Liu, Yang Li, Jianping Ruan, Yongqing Huang
Summary: Fluoride-induced endoplasmic reticulum (ER) stress is responsible for enamel mineralization disorder. This study investigated the mechanisms of fluoride-induced ER stress and autophagy in ameloblasts, and the regulatory role of ER molecular chaperone GRP78 in fluoride-induced autophagy.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Microbiology
Xingang Xu, Jingjing Wang, Yuting Zhang, Yuchao Yan, Yi Liu, Xiaojie Shi, Qi Zhang
Summary: This study reveals the potential role of DDX6 in regulating autophagy during PEDV infection. DDX6 protein expression is down-regulated while mRNA expression is up-regulated in PEDV-infected cells. Overexpression of DDX6 inhibits PEDV replication, while knockdown of DDX6 promotes viral replication. PEDV-induced ER stress down-regulates DDX6 protein level, and silencing of DDX6 alleviates ER stress and cell apoptosis.
VETERINARY MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dongmei Liu, Muriel Mari, Xia Li, Fulvio Reggiori, Susan Ferro-Novick, Peter Novick
Summary: This study discovered a process called ER-phagy, which selectively delivers fragments of the endoplasmic reticulum to the lysosome or vacuole in response to starvation or the accumulation of misfolded proteins. The loss of specific genes and proteins blocks the association between the autophagy receptor and the assembly scaffold protein, and a membrane contact site module is also found to be involved in ER-phagy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Jee-Eun Lee, Nari Kim, Minkyo Jung, Ji-Young Mun, Joo-Yeon Yoo
Summary: SHISA5 acts as an autophagy suppressor by blocking the contact between the phagophore and endoplasmic reticulum exit sites under basal conditions. Cells lacking SHISA5 display enhanced autophagy, which requires specific phosphatidylinositol 3-kinase complex I activity and functional assembly of endoplasmic reticulum exit sites.
Article
Oncology
Youngsic Jeon, Taejung Kim, Hyukjoon Kwon, Jeong-Kook Kim, Young-Tae Park, Jungyeob Ham, Young-Joo Kim
Summary: This study provides evidence that the combination treatment of cabozantinib and CBD leads to increased apoptosis in HCC cells. This enhanced apoptosis is mediated, at least in part, through the induction of ER stress and subsequent activation of the p53 pathway. However, there is no association found between the combination treatment and CNR.
Editorial Material
Microbiology
Denis Voronin, Benjamin L. Makepeace
Summary: This study compared the development of Drosophila species with systemic or restricted infections and found that the restricted pattern is determined by an autophagic process, which has important implications for evolution and control of Wolbachia infections.
Article
Oncology
Lei Yu, Ji-Guang Hou, Yun-Feng LI, Yin Wang, Ming Hong, Yan-Ming Yang
Summary: The study showed that TMS can induce apoptotic cell death and ERS-mediated autophagy in colon cancer cells, with ERS not being involved in TMS-induced apoptosis; inhibiting ERS can enhance the pro-apoptotic effects of TMS, suggesting TMS as a potential therapeutic agent for colon cancer.
Article
Endocrinology & Metabolism
Cuneyt Caglayan, Fatih Mehmet Kandemir, Adnan Ayna, Cihan Gur, Sefa Kucukler, Ekrem Darendelioglu
Summary: The study investigated the protective effect of 18 beta-glycyrrhetinic acid (18 beta-GA) on bisphenol A (BPA) induced neurotoxicity. The results showed that 18 beta-GA could ameliorate oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway activation caused by BPA in the brain tissues.
METABOLIC BRAIN DISEASE
(2022)
Article
Cell Biology
Wenjun Wang, Jianshuang Li, Qinghua Zhou
Summary: ENDOG can be released from mitochondria and translocate to the nucleus, cytoplasm, and mitochondrial matrix in response to various stress stimuli. It regulates different biological functions, including DNA digestion, apoptosis, autophagy, mitophagy, and lipid synthesis, through interactions with crucial proteins.
Article
Immunology
Shuang Wang, Guangsuo Wang, Weiqing Wu, Zhenglei Xu, Jing Yang, Min Cao, Qi Wang, Jigang Wang, Chuanbin Yang, Wei Zhang
Summary: This study finds that piceatannol, a dietary phenolic compound, can enhance the anticancer immune response induced by the chemotherapy drug oxaliplatin (OXA) through inducing autophagy. Piceatannol promotes the release of immune response-triggering substances and improves the efficacy of chemotherapy. Additionally, piceatannol induces endoplasmic reticulum stress, leading to increased cell surface exposure of calreticulin. The combination of piceatannol and OXA also enhances the anticancer effects in immunocompetent mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Anatomy & Morphology
Ziwei Cui, Ruoshan Qin, Jianbao Feng, Yuan Liu, Xiongtao Zhou, Xiaodong Qin, Yanmin Li, Zhidong Zhang, Xiangyi He
Summary: This study investigated the effect and mechanism of XBP1s, cleaved by IRE1α, on the proliferation and osteogenesis of hPDLCs. It was found that XBP1s promotes hPDLCs proliferation, regulates autophagy and apoptosis, and enhances expression of osteogenic genes.
Article
Environmental Sciences
Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Yan
Summary: The study demonstrated that chronic exposure to ACR can impair motor skills, muscle strength, and coordination in rats, as well as damage the morphology of the cerebellum, leading to increased apoptosis and initiation of autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Ajda Coker-Gurkan, Esin Can, Semanur Sahin, Pinar Obakan-Yerlikaya, Elif-Damla Arisan
Summary: Atiprimod demonstrates inhibitory effects on breast cancer cell growth and apoptosis in vitro by affecting the activity of STAT3 and NF-kappa B, as well as inducing ER stress within the cells. In cell experiments, atiprimod shows great potential as an anti-cancer therapy.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Endocrinology & Metabolism
Imke L. Lemmer, Nienke Willemsen, Nazia Hilal, Alexander Bartelt
Summary: This review provides a general guide to understanding the nature, etiology, and consequences of ER stress in metabolic disorders, emphasizing key mechanisms such as protein quality control, lipid and carbohydrate metabolism, and inflammation.
MOLECULAR METABOLISM
(2021)