期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 10, 期 9, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a029124
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资金
- National Institutes of Health (NIH) Center for HIV AIDS Vaccine Immunology Immunogen Discovery Grant [UM1 AI 00645-02]
- Medical Research Council Programme [MR/K012037/2]
- MRC [MR/K012037/1] Funding Source: UKRI
Vaccines that stimulate CD8(+) T cells could clear early virus infection or control ongoing infection and prevent disease. This could be valuable to combat human immunodeficiency virus type 1 (HIV-1) where it has not yet been possible to generate broadly reacting neutralizing antibodies with a vaccine. However, HIV-1 vaccines aimed at stimulating CD8(+) T cells have had no success. In contrast, a cytomegalovirus vectored simian immunodeficiency virus (SIV) vaccine enabled clearance of early SIV infection. This may open the door to the design of an effective HIV vaccine
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