Negative auto-regulators trap p53 in their web

miR-214 promotes apoptosis and sensitizes breast cancer cells to doxorubicin by targeting the RFWD2-p53 cascade

(2016) Jiaxuan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner

(2016) A. Esfandiari et al.   MOLECULAR CANCER THERAPEUTICS

Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End

(2016) Amanda R. Wasylishen et al.   Cold Spring Harbor Perspectives in Medicine

Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator

(2016) Xiang Zhou et al.   eLife

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Ribosomal proteins: functions beyond the ribosome

(2015) Xiang Zhou et al.   Journal of Molecular Cell Biology

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis

(2014) Yiwei Zhang et al.   DEVELOPMENTAL BIOLOGY

Tissue-specific and age-dependent effects of global Mdm2 loss

(2014) Yun Zhang et al.   JOURNAL OF PATHOLOGY

TRIM24 Is a p53-Induced E3-Ubiquitin Ligase That Undergoes ATM-Mediated Phosphorylation and Autodegradation during DNA Damage

(2014) A. K. Jain et al.   MOLECULAR AND CELLULAR BIOLOGY

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers

(2014) Haiyang Yu et al.   Nature Communications

The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity

(2013) V. Pant et al.   GENES & DEVELOPMENT

XPC promotes MDM2-mediated degradation of the p53 tumor suppressor

(2013) Jing Yan Krzeszinski et al.   MOLECULAR BIOLOGY OF THE CELL

Regulatory feedback loop between TP73 and TRIM32

(2013) L Gonzalez-Cano et al.   Cell Death & Disease

The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage

(2012) Ali Zhang et al.   CELL RESEARCH

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53

(2012) Qi Zhang et al.   EMBO Molecular Medicine

Global Effect of Inauhzin on Human p53-Responsive Transcriptome

(2012) Jun-Ming Liao et al.   PLoS One

CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination

(2011) Paolo Latini et al.   CELL CYCLE

Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas

(2011) J. Zhang et al.   GENES & DEVELOPMENT

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

(2011) Domenico Migliorini et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

(2011) V. Pant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

(2011) L. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nerve Growth Factor in Cancer Cell Death and Survival

(2011) Niamh Molloy et al.   Cancers

p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors

(2010) Baozong Li et al.   CELL CYCLE

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity

(2010) Hussein A. Abbas et al.   Cell Stem Cell

HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of theHDMXGene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

(2010) Anna Phillips et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

(2009) Yunyuan V. Wang et al.   CANCER CELL

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

(2009) Qian Cheng et al.   EMBO JOURNAL

Trim24 targets endogenous p53 for degradation

(2009) Kendra Allton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

(2008) Yaara Ofir-Rosenfeld et al.   MOLECULAR CELL

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY