Review
Immunology
Caroline M. Weight, Simon P. Jochems, Hugh Adler, Daniela M. Ferreira, Jeremy S. Brown, Robert S. Heyderman
Summary: Nasopharyngeal carriage of Streptococcus pneumoniae is common in humans, especially in older individuals. Pneumococcal conjugate vaccines have had some success in protecting young children and indirectly older people through herd immunity, but serotype replacement is still a concern. Older individuals often experience chronic inflammation, known as 'Inflammageing', which may increase mortality risk and affect the outcome of pneumococcal infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wenjie Yang, Yang Li, Diana Boraschi
Summary: Plastic pollution is a global problem that poses risks to the environment and human health. Discarded plastic degrades into microplastics (MPs) in the environment, which can interact with microorganisms and biomolecules. These interactions can modify the characteristics of microbes and biomolecules, potentially affecting the immune response and leading to risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Jianya Peng, Hannah G. G. Federman, Christina M. Hernandez, Mark C. C. Siracusa
Summary: Parasitic helminth infections are a global health issue, causing significant morbidity and economic hardships. Host protective responses to helminths involve the initiation of type 2 inflammation and the involvement of various immune cells. Recent studies have also highlighted the importance of neuro-immune interactions in regulating anti-helminth immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Eliza Gil, Mahdad Noursadeghi, Jeremy S. Brown
Summary: Innate and adaptive immunity to Streptococcus pneumoniae infection is dependent on the complement system. The activation of the complement system by S. pneumoniae is crucial for host defense against infection. The complement system can be activated through different mechanisms, leading to the clearance of the pathogen and protection against invasive infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eleanor K. P. Marshall, Marc S. Dionne
Summary: Fruit fly Drosophila melanogaster has emerged as an important model for studying host-pathogen interactions, particularly in the context of mycobacterial infections. Studies using Drosophila have identified key factors involved in controlling or resisting mycobacterial infections, laying the groundwork for further research into the interaction between host and pathogen factors. The development of genetic tools for manipulating mycobacterial genomes holds promise for more detailed investigations using the fruit fly model, although its full potential has yet to be fully realized.
MOLECULAR MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Felicia Kuperwaser, Gal Avital, Michelle J. Vaz, Kristen N. Noble, Allison N. Dammann, Tara M. Randis, David M. Aronoff, Adam J. Ratner, Itai Yanai
Summary: Group B Streptococcus (GBS) is a pathobiont that ascends to the placenta and causes adverse pregnancy outcomes by producing the toxin beta-hemolysin/cytolysin (beta-h/c). This study shows that GBS modulates the state of innate immune cells by subverting host inflammation through beta-h/c, leading to worse outcomes.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yu Hao, Bo Yang, Jinke Yang, Xijuan Shi, Xing Yang, Dajun Zhang, Dengshuai Zhao, Wenqian Yan, Lingling Chen, Haixue Zheng, Keshan Zhang, Xiangtao Liu
Summary: ZBP1 plays an important role in innate immune response and inflammatory cell death. Its signaling depends on the recognition of Z-nucleic acid and interaction with adapter proteins. ZBP1-activated immune response is crucial for host defense, while excessive cell death can be harmful. Both pathogens and host have developed strategies to interfere with ZBP1 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Wan Rong Sia, Yichao Zheng, Fei Han, Shiwei Chen, Shaohua Ma, Lin-Fa Wang, Edwin Leeansyah
Summary: Bats are natural carriers of many important viruses in global public health, but they rarely suffer from diseases. Their immune system consists of both innate and adaptive systems to detect and respond to pathogens. Innate lymphocytes, which are abundant in bats, play a significant role in the early defense against viral infections. A deeper understanding of bat immunity can help prevent zoonotic disease transmission and identify new therapeutic targets. However, the research in bat immune systems is hindered by the lack of bat-specific research tools.
Review
Immunology
David P. Maison, Youping Deng, Mariana Gerschenson
Summary: The SARS-CoV-2 pandemic and COVID-19 disease have had a global impact, sparking a significant surge in research. To evaluate future approaches, understanding the host immune response and viral antagonism is crucial. This review summarizes current knowledge on SARS-CoV-2, focusing on the viral genome, replication cycle, host immune activation, response, signaling, and antagonism. Efforts should be directed towards current research to develop treatments and prepare for future outbreaks.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Dylan Minor, Jacob Cavon, Thea Johnson, Savannah Ontiveros, Daniel Gao, Mark T. Quinn, Benfang Lei
Summary: In this study, we investigated whether MyD88 KO mice were susceptible to acute group A Streptococcus (GAS) infection through transmission. We found that MyD88(-/-) recipient mice had increased GAS loads in the nasal cavity and throat and became moribund after commingling with GAS-infected mice. Furthermore, we observed that MyD88 signaling is critical for protection of the respiratory tract lamina propria but not nasal and nasopharyngeal epithelia against GAS infection.
INFECTION AND IMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Quanhui Yan, Xiaodi Liu, Yawei Sun, Weijun Zeng, Yuwan Li, Feifan Zhao, Keke Wu, Shuangqi Fan, Mingqiu Zhao, Jinding Chen, Lin Yi
Summary: This review summarizes recent advances in autophagy, apoptosis, and innate immunity induced by swine enteric coronavirus (SeCoV) infection, emphasizing their relationship with viral replication and signaling pathway alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Stephan Brouwer, Magnus G. Jespersen, Cheryl-Lynn Y. Ong, David M. P. De Oliveira, Bernhard Keller, Amanda J. Cork, Karrera Y. Djoko, Mark R. Davies, Mark J. Walker
Summary: In this study, the researchers found that the ABC transporter substrate binding protein GshT is a crucial component of the glutathione salvage pathway in glutathione-auxotrophic GAS. Host-acquired glutathione is essential for the GAS antioxidant defense system, enabling it to evade the host innate immune response. This study provides mechanistic insights into how extracellular bacterial pathogens like GAS exploit host glutathione for their own benefit.
Review
Microbiology
Mareva Bleuze, Marcelo Gottschalk, Mariela Segura
Summary: Streptococcus suis infection can lead to various clinical manifestations mainly due to exacerbated inflammation, in which neutrophils play a key role. However, research on the functions and roles of neutrophils in Streptococcus suis infection is still limited.
Review
Nanoscience & Nanotechnology
Xiaodong Zhang, Xiaokai Chen, Yanli Zhao
Summary: Artificial nanosystems have the ability to modulate immune responses and can be used in vaccine development and treatment of bacterial infections and diseases. This review discusses the recent advances of nanosystems in vaccine development and immune activation, as well as the application of immune-suppressive nanosystems.
ACS APPLIED NANO MATERIALS
(2022)
Article
Microbiology
Jonas Lannergard, Bodil M. Kristensen, Mattias C. U. Gustafsson, Jenny J. Persson, Anna Norrby-Teglund, Margaretha Stalhammar-Carlemalm, Gunnar Lindahl
Article
Microbiology
Onkar Sharma, Maghnus O'Seaghdha, Jorge J. Velarde, Michael R. Wessels
News Item
Microbiology
Gunnar Lindahl, Jenny J. Persson
Nature Microbiology
(2016)
Article
Microbiology
Jorge J. Velarde, Maghnus O'Seaghdha, Buket Baddal, Benedicte Bastiat-Sempe, Michael R. Wessels
Article
Biochemistry & Molecular Biology
Felipe A. Pinho-Ribeiro, Buket Baddal, Rianne Haarsma, Maghnus O'Seaghdha, Nicole J. Yang, Kimbria J. Blake, Makayla Portley, Waldiceu A. Verri, James B. Dale, Michael R. Wessels, Isaac M. Chiu
Article
Multidisciplinary Sciences
Tania Claro, Amro Widaa, Maghnus O'Seaghdha, Helen Miajlovic, Timothy J. Foster, Fergal J. O'Brien, Steven W. Kerrigan
Article
Microbiology
Brenda G. Byrne, Jean-Francois Dubuisson, Amrita D. Joshi, Jenny J. Persson, Michele S. Swanson
Article
Microbiology
Maghnus O'Seaghdha, Michael R. Wessels
Article
Immunology
Adriana Flores-Langarica, Charlotte Cook, Katarzyna Muller Luda, Emma K. Persson, Jennifer L. Marshall, Nonantzin Beristain-Covarrubias, Juan Carlos Yam-Puc, Madelene Dahlgren, Jenny J. Persson, Satoshi Uematsu, Shizuo Akira, Ian R. Henderson, Bengt Johansson Lindbom, William Agace, Adam F. Cunningham
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Dora Hancz, Elsa Westerlund, Christine Valfridsson, Getachew Melkamu Aemero, Benedicte Bastiat-Sempe, Pontus Orning, Egil Lien, Michael R. Wessels, Jenny J. Persson
JOURNAL OF INNATE IMMUNITY
(2019)
Article
Immunology
Elsa Westerlund, Christine Valfridsson, Daisy X. Yi, Jenny J. Persson
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Shiva Emami, Thiago Rojas Converso, Jenny J. Persson, Bengt Johansson-Lindbom
Summary: This study investigates the cellular and molecular basis for protective adaptive immune responses against Group A Streptococcus (GAS) using a murine immunization model. The findings show that a GAS strain carrying the immunodominant 2W T helper cell epitope within the M protein elicits a protective immune response. This protection is dependent on IFN-α and is associated with elevated levels of the complement-fixing IgG2c subclass.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Andrzej Pawlowski, Jonas Lannergard, Majela Gonzalez-Miro, Duojia Cao, Sara Larsson, Jenny J. Persson, Geoff Kitson, Michael Darsley, Ane Lilleore Rom, Morten Hedegaard, Per B. Fischer, Bengt Johansson-Lindbom
Summary: Maternal vaccination is a promising strategy for preventing neonatal disease caused by group B Streptococcus. Recent studies have shown that vaccine-induced immune responses play a crucial role in preventing bacterial invasion and opsonophagocytic killing, while pre-existing immunity may impact the effectiveness of vaccination.
CELL REPORTS MEDICINE
(2022)