Article
Biotechnology & Applied Microbiology
Nasir Mohajel, Arash Arashkia
Summary: Surveying patenting activity can help coordinate R&D efforts in combating emerging infectious diseases.
NATURE BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Placide Mbala-Kingebeni, Catherine Pratt, Mbusa Mutafali-Ruffin, Matthias G. Pauthner, Faustin Bile, Antoine Nkuba-Ndaye, Allison Black, Eddy Kinganda-Lusamaki, Martin Faye, Amuri Aziza, Moussa M. Diagne, Daniel Mukadi, Bailey White, James Hadfield, Karthik Gangavarapu, Nella Bisento, Donatien Kazadi, Bibiche Nsunda, Marceline Akonga, Olivier Tshiani, John Misasi, Aurelie Ploquin, Victor Epaso, Emilia Sana-Paka, Yannick Tutu Tshia N'kasar, Fabrice Mambu, Francois Edidi, Meris Matondo, Junior Bula Bula, Boubacar Diallo, Mory Keita, Marie R. D. Belizaire, Ibrahima S. Fall, Abdoulaye Yam, Sabue Mulangu, Anne W. Rimion, Elias Salfati, Ali Torkamani, Marc A. Suchard, Ian Crozier, Lisa Hensley, Andrew Rambaut, Ousmane Faye, Amadou Sall, Nancy J. Sullivan, Trevor Bedford, Kristian G. Andersen, Michael R. Wiley, Steve Ahuka-Mundeke, Jean-Jacques Muyembe Tamfum
Summary: During the Ebola virus disease outbreak in the Democratic Republic of Congo, a young man developed EVD, recovered after receiving monoclonal antibody treatment, but later experienced a relapse, transmitted the virus, and ultimately died.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Virology
Isaac Downs, Joshua C. Johnson, Franco Rossi, David Dyer, David L. Saunders, Nancy A. Twenhafel, Heather L. Esham, William D. Pratt, John Trefry, Elizabeth Zumbrun, Paul R. Facemire, Sara C. Johnston, Erin L. Tompkins, Nathan K. Jansen, Anna Honko, Anthony P. Cardile
Summary: Ebola virus disease is a serious global health concern with high mortality rates, requiring well-defined nonhuman primate models for testing candidate countermeasures. This study found that aerosol-exposed rhesus macaques displayed early markers of disease and a distinct disease course compared to intramuscularly challenged animals.
Article
Multidisciplinary Sciences
Jingru Fang, Guillaume Castillon, Sebastien Phan, Sara McArdle, Chitra Hariharan, Aiyana Adams, Mark H. Ellisman, Ashok A. Deniz, Erica Ollmann Saphire
Summary: Ebola virus infection induces the formation of biomolecular condensates called viral factories, which coordinate viral transcription, replication, and assembly. The authors characterized the phase separation properties and internal structures of intracellular viral factories induced by Ebola virus, and correlated these properties to important steps of viral biogenesis.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Ermela Paparisto, Nina R. Hunt, Daniel S. Labach, Macon D. Coleman, Eric J. Di Gravio, Mackenzie J. Dodge, Nicole J. Friesen, Marceline Cote, Andreas Muller, Thomas Hoenen, Stephen D. Barr
Summary: Survival after Ebola virus infection is closely linked to an early and robust interferon response. Research has identified that the IFN-induced HERC5 protein can inhibit EBOV replication by depleting viral mRNAs, and also shows an antagonist relationship with the virus glycoprotein during early infection, potentially leading to the development of novel antiviral therapeutics.
Article
Multidisciplinary Sciences
Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Shannon G. M. Kirejczyk, Jonathan S. Towner
Summary: This study demonstrates that Egyptian rousette bats (ERBs) are natural vertebrate hosts for Kasokero virus (KASV) and can sustain viremias of appropriate magnitude and duration, supporting virus maintenance through bat-tick-bat transmission cycles. The results also suggest the potential for bat-to-bat transmission and spillover of KASV to humans through contact with infectious oral secretions, feces, or urine.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Wenwu Yao, Zhangnv Yang, Xiuyu Lou, Haiyan Mao, Hao Yan, Yanjun Zhang
Summary: A cost-effective, multipathogen and high-throughput method was developed for simultaneous detection of Ebola virus and other pathogens associated with hemorrhagic fever, demonstrating excellent specificity, sensitivity, and concordance with real-time PCR analysis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Luke Nyakarahuka, Sophia Mulei, Shannon Whitmer, Kyondo B. Jackson, Alex M. Tumusiime, Amy Schuh, Jimmy J. Baluku, Allison D. Joyce, Felix R. Ocom, Jayne Tusiime, Joel Montgomery, Stephen Balinandi, Julius Lutwama, John Klena, Trevor Shoemaker
Summary: This publication demonstrates how Uganda managed to control the introduction of Ebola Virus Disease (EVD) from the Democratic Republic of Congo (DRC) in 2019. By intensifying cross-border surveillance and implementing international health regulations, they successfully limited the spread of the virus in Uganda. Three cases were identified and contained, with no onward transmission. This experience can serve as a model for cross-border surveillance and control of infectious disease outbreaks.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Virology
Rebecca Johnson, Beata Boczkowska, Kendra Alfson, Taylor Weary, Heather Menzie, Jenny Delgado, Gloria Rodriguez, Ricardo Carrion, Anthony Griffiths
Summary: This study found that defective viral genomes (DVGs) accumulate in nonhuman primates infected with Ebola virus (EBOV) and Sudan virus (SUDV), particularly in the testes of infected NHPs. The presence of these DVGs in the viral infections indicates a potential role in EBOV and SUDV pathogenesis, and further research is needed to understand their significance in disease persistence.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Robert W. Cross, Abhishek N. Prasad, Courtney B. Woolsey, Krystle N. Agans, Viktoriya Borisevich, Natalie S. Dobias, Jason E. Comer, Daniel J. Deer, Joan B. Geisbert, Angela L. Rasmussen, Walter Ian Lipkin, Karla A. Fenton, Thomas W. Geisbert
Summary: Transmission of Ebola virus primarily occurs through contact exposure of mucosal surfaces with infected body fluids. Nonhuman primate challenge studies have shown that routes of infection mimicking worst-case scenarios are lethal, while natural routes of exposure result in delayed onset of disease and reduced mortality. A series of conjunctival exposure studies in macaques revealed that a high dose of 10,000 plaque forming units (PFU) of EBOV was uniformly lethal, while lower doses of 100 or 500 PFU resulted in survival. Asymptomatic infection was observed in survivors with limited detection of EBOV replication. Inconsistent seropositivity in survivors may suggest the presence of physical or natural immunological barriers to prevent widespread viral dissemination.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Sanmitra Ghosh, Abinit Saha, Saikat Samanta, Rudra P. Saha
Summary: Ebola, a deadly pathogen responsible for Ebola virus disease, first emerged in 1976. Understanding its genomic structure is crucial for developing effective antiviral therapy. Comprehensive knowledge of its genomic structure and variations will facilitate the design of effective treatments, whether through vaccine development or antiviral drugs.
CURRENT OPINION IN PHARMACOLOGY
(2021)
Article
Microbiology
Ke Jin, Yan Dai, Ke Ouyang, Huaying Huang, Zhengyi Jiang, Zhan Yang, Tingting Zhou, Hong Lin, Chunhui Wang, Chunyan Wang, Xuewei Sun, Dafeng Lu, Xiaoguang Liu, Nannan Hu, Chuanlong Zhu, Jin Zhu, Jun Li
Summary: This study found that TRIM3 gene expression is decreased in SFTS patients, especially in severe cases. In the IFNAR(-/-) SFTS mouse model, TRIM3 gene and protein expression were also reduced. Further experiments demonstrated that TRIM3 inhibits cytokine production by promoting TLR3 degradation through K48-linked ubiquitination, thereby exerting anti-inflammatory effects. This suggests that TRIM3 may be a therapeutic target for improving the prognosis of SFTS.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pathology
David X. Liu, Timothy K. Cooper, Donna L. Perry, Louis M. Huzella, Amanda M. W. Hischak, Randy J. Hart, Nejra Isic, Russell Byrum, Danny Ragland, Marisa St Claire, Kurt Cooper, Rebecca Reeder, James Logue, Peter B. Jahrling, Michael R. Holbrook, Richard S. Bennett, Lisa E. Hensley
Summary: The study found that Ebola virus can cause various reproductive organ diseases and replicates in other organs as well, providing new perspectives on sexual transmission, disruption of hormone production, and early virus replication in human EVD patients.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Microbiology
Sarah van Tol, Birte Kalveram, Philipp A. Ilinykh, Adam Ronk, Kai Huang, Leopoldo Aguilera-Aguirre, Preeti Bharaj, Adam Hage, Colm Atkins, Maria Giraldo, Maki Wakamiya, Maria Gonzalez-Orozco, Abbey N. Warren, Alexander Bukreyev, Alexander N. Freiberg, Ricardo Rajsbaum
Summary: This study identified the important role of VP35 ubiquitination in coordinating viral transcription and assembly. Ubiquitination facilitates optimal viral transcriptional polymerase co-factor function without affecting transcriptional initiation. The loss of a basic charge at position 309 further compromises VP35's function through diminished interaction with the viral matrix protein and type-I interferon antagonism. Overall, ubiquitination and retention of a basic residue at VP35 position 309 are critical for viral transcription and assembly.
Review
Emergency Medicine
Summer Chavez, Alex Koyfman, Michael Gottlieb, William J. Brady, Brandon M. Carius, Stephen Y. Liang, Brit Long
Summary: Ebolavirus, the causative agent of Ebola virus disease (EVD), has been responsible for sporadic outbreaks in sub-Saharan Africa since 1976. EVD is highly transmissible, especially to healthcare workers. This review provides a concise overview of EVD presentation, diagnosis, and management for emergency clinicians. Treatment mainly involves supportive care and two approved monoclonal antibody treatments.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Developmental Biology
Richard E. Heinz, Michael C. Rudolph, Palani Ramanathan, Nicole S. Spoelstra, Kiel T. Butterfield, Patricia G. Webb, Beatrice L. Babbs, Hongwei Gao, Shang Chen, Michael A. Gordon, Steve M. Anderson, Margaret C. Neville, Haihua Gu, Jennifer K. Richer
Article
Immunology
Michelle Meyer, Eric Huang, Olga Yuzhakov, Palaniappan Ramanathan, Giuseppe Ciaramella, Alexander Bukreyev
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Oncology
Heidi K. Baumgartner, Michael C. Rudolph, Palaniappian Ramanathan, Valerie Burns, Patricia Webb, Benjamin G. Bitler, Torsten Stein, Ken Kobayashi, Margaret C. Neville
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
(2017)
Article
Microbiology
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I. Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A. Koup, Michael G. Katze, Alexander Bukreyev
Article
Microbiology
Andrew I. Flyak, Natalia Kuzmina, Charles D. Murin, Christopher Bryan, Edgar Davidson, Pavlo Gilchuk, Christopher P. Gulka, Philipp A. Ilinykh, Xiaoli Shen, Kai Huang, Palaniappan Ramanathan, Hannah Turner, Marnie L. Fusco, Rebecca Lampley, Nurgun Kose, Hannah King, Gopal Sapparapu, Benjamin J. Doranz, Thomas G. Ksiazek, David W. Wright, Erica Ollmann Saphire, Andrew B. Ward, Alexander Bukreyev, James E. Crowe
NATURE MICROBIOLOGY
(2018)
Article
Immunology
Patrick Younan, Mathieu Iampietro, Rodrigo I. Santos, Palaniappan Ramanathan, Vsevolod L. Popov, Alexander Bukreyev
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Immunology
Patrick Younan, Mathieu Iampietro, Rodrigo I. Santos, Palaniappan Ramanathan, Vsevolod L. Popov, Alexander Bukreyev
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Virology
Bersabeh Tigabu, Palaniappan Ramanathan, Andrey Ivanov, Xionghao Lin, Philipp A. Ilinykh, Christian S. Parry, Alexander N. Freiberg, Sergei Nekhai, Alexander Bukreyev
JOURNAL OF VIROLOGY
(2018)
Article
Cell Biology
Michelle Meyer, Asuka Yoshida, Palaniappan Ramanathan, Erica Ollmann Saphire, Peter L. Collins, James E. Crowe, Siba Samal, Alexander Bukreyev
Article
Cell Biology
Natalia A. Kuzmina, Patrick Younan, Pavlo Gilchuk, Rodrigo Santos, Andrew Flyak, Philipp A. Ilinykh, Kai Huang, Ndongala M. Lubaki, Palaniappan Ramanathan, James E. Crowe, Alexander Bukreyev
Article
Microbiology
Jingru Fang, Colette Pietzsch, Palaniappan Ramanathan, Rodrigo I. Santos, Philipp A. Ilinykh, Mariano A. Garcia-Blanco, Alexander Bukreyev, Shelton S. Bradrick
Article
Biochemistry & Molecular Biology
Andrey Ivanov, Palaniappan Ramanathan, Christian Parry, Philipp A. Ilinykh, Xionghao Lin, Michael Petukhov, Yuri Obukhov, Tatiana Ammosova, Gaya K. Amarasinghe, Alexander Bukreyev, Sergei Nekhai
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Multidisciplinary Sciences
James J. Zhu, Palaniappan Ramanathan, Elizabeth A. Bishop, Vivian O'Donnell, Douglas P. Gladue, Manuel Borca
Meeting Abstract
Immunology
Christian Parry, Andrey Lvanov, Palaniappan Ramanathan, Philipp A. Llinykh, Xionghao Lin, Tatiana Annnnosova, Alexander Bukreyev, Sergei Nekhai
JOURNAL OF IMMUNOLOGY
(2017)