期刊
JOURNAL OF FUNCTIONAL FOODS
卷 30, 期 -, 页码 63-73出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.12.039
关键词
Cranberry concentrate; Grape seed extract; Proanthocyanidins Redox state; Anti-aging
资金
- National Natural Science Foundation of China [31401659]
- Foundation for the Author of a Nationally Excellent Doctoral Dissertation of China [201260]
We investigated the anti-aging and redox state regulation effects by A-type proanthocyanidins (PACs) rich cranberry concentrate (CBC) and its comparison with B-type PACs-rich grape seed extract (GSE). Using the Q-Extractive mass spectrometry, PACs dimer A and B were identified as predominant phenolic compounds of CBC and GSE, respectively, while epicatechin was present in both extracts. Using the D-galactose-induced aging mice model, effects were investigated via an 8-week oral gavage considering water-soluble vitamin E as the positive control. Both CBC and GSE reduced hepatic and brain thiobarbituric acid reactive substances, and plasma 8-isoprostane levels by 30-57%, 24-30% and 11-62%, respectively, and decreased brain and plasma monoamine oxidase activities by 27-59% and 65-71%, respectively. CBC could improve hepatic glutathione peroxidase activity by 42%, while GSE increased hepatic superoxide dismutase activity by 13%. Therefore, both extracts exerted anti-aging effects probably via regulating in vivo redox state. However, neither generated any effect on catalase activities. (C) 2016 Elsevier Ltd. All rights reserved.
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