期刊
JOURNAL OF FUNCTIONAL FOODS
卷 29, 期 -, 页码 84-92出版社
ELSEVIER
DOI: 10.1016/j.jff.2016.12.001
关键词
Diet; Immunomodulation; Inflammation; Lupus; Phenols; SLE
资金
- Ministerio de Economia y Competitividad, Spain [AGL 2011-26949]
- Junta de Andalucia, Spain [P-10AGR-6609]
- Postgraduate National Program of FPU fellowship
- Spanish Ministerio de Educacion, Cultura y Deporte
Current experimental studies suggest a beneficial role of dietary phenolic compounds on prevention and management of immune-inflammatory disorders. Systemic lupus erythematosus (SLE), a multisystemic autoimmune chronic disease, remains without an effective and safe treatment. Thus, diet therapy could be a promising approach in SLE due to its potential prophylactic effects without the side effects of classical pharmacology. This study evaluates the effects of diets supplemented with phenolic compounds: hydroxytyrosol (HTy) and hydroxytyrosyl acetate (HTy-Ac) in pristane-induced SLE mice. Peritoneal macrophages and spleens were isolated and cultured to evaluate cytokines levels by Enzyme-Linked Immunosorbent Assay (ELISA). Renal changes of inflammatory markers and signaling pathways were determined by western blot. Dietary phenol supplementation significantly reduced pro-inflammatory cytokines and prevented renal damage with a considerably blockage of different inflammatory-related pathways suggesting that HTy and HTy-Ac supplementation might provide a basis for developing a new dietary strategy for prevention and management of SLE. (C) 2016 Published by Elsevier Ltd.
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