Article
Biochemistry & Molecular Biology
Hitomi Ohinata, Takashi Obama, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe
Summary: This study found that high-density lipoproteins (HDL) partially decreased neutrophil extracellular trap (NET) formation induced by copper-oxidized low-density lipoprotein (oxLDL). It was also discovered that oxidized phosphatidylcholines and lysophosphatidylcholine in oxLDL promoted NET formation, which could be completely blocked by native HDL. Furthermore, an electronegative subfraction of LDL, LDL(-), was found to promote NET formation. These findings suggest that plasma lipoproteins and their oxidative modifications play multiple roles in promoting NET formation, and HDL acts as a suppressor of this response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Ho-Jeong Bang, Mok-Ryeon Ahn
Summary: This study found that pinobanksin exhibits antiangiogenic effect by inducing endothelial cell apoptosis, and it can be developed as an antiangiogenic agent. The mechanism involves inactivation of the Raf/MEK/ERK pathway and activation of apoptotic signaling such as caspase cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biotechnology & Applied Microbiology
Hui Kang, Hui Yu, Jingxiu Fan, Ge Cao
Summary: Rotigotine shows beneficial effects on Ox-LDL-induced endothelial cell damage, including inhibition of cholesterol accumulation, improvement of monocyte adhesion, reduction of oxidative stress and inflammation. Its potential therapeutic role in cardiovascular diseases is highlighted through these effects.
Article
Medicine, Research & Experimental
Jun Miao, Bo Wang, Ran Shao, Yan Wang
Summary: The study demonstrated that circUSP36 regulates ox-LDL-induced injury and inflammation in HUVECs by modulating ROCK2 via competitively targeting miR-20a-5p. MiR-20a-5p is found to be a target of circUSP36, and its inhibition reverses the effects of circUSP36 knockdown. These findings reveal the significant role of circUSP36 in the pathogenesis of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yi Zeng, Chun Yan Wang, Jin Xu, Xiao Le Xu
Summary: This study reveals that RXR13 exerts protective effects against ox-LDL-induced inflammation in endothelial cells, potentially through regulating PGC1α-dependent mitochondrial homeostasis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Environmental Sciences
Jiajing Cui, Pingwei Wang, Shuqi Yan, Yujun Liang, Dongge Liu, Shuping Ren
Summary: The study aims to explore the role of ferroptosis in endothelial cell dysfunction and its underlying mechanisms.
Article
Acoustics
JiaYi Li, WeiMing Guo, Fei Yu, Lu Liu, XiaoTing Wang, LvYuan Li, Bing Fang, Lunguo Xia
Summary: The study demonstrated that LIPUS could promote the proliferation and angiogenic differentiation of endothelial cells (ECs) via the activation of the AKT signaling pathway. Additionally, LIPUS could alter the DNA methylation of ECs through the AKT signaling pathway activation, which in turn affected biomolecular changes in the cells.
Article
Biochemistry & Molecular Biology
Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi, Michael Keese
Summary: The study revealed a novel biphasic response of human umbilical vein endothelial cells to blue light illumination. Low fluence blue light promoted cell activities, while high fluence illumination had the opposite effect by upregulating pro-apoptotic signaling pathways. These findings provide insights into photobiomodulation by blue light and potential treatment strategies for angiogenesis-dependent diseases.
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Article
Biochemistry & Molecular Biology
Sivanan Sivasinprasasn, Naruemon Wikan, Jiraporn Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus
Summary: The study revealed that the combined application of PAVA and RSV can inhibit ox-LDL-induced inflammatory responses, decrease activation of NF-KB/NLRP3 pathway, reduce recruitment of monocytes, and ameliorate impairment of cell-cell junctions, offering a novel mechanism for the treatment of cardiovascular diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Lifeng Zhao, Ruixi Luo, Honghong Yu, Shuaishuai Li, Qi Yu, Wenjia Wang, Kun Cai, Tao Xu, Rui Chen, Weiyi Tian
Summary: Curcumin can ameliorate endothelial lipotoxicity induced by high oxLDL by inducing autophagy in HUVECs, and it may modulate the expression of key proteins in the AMPK/mTOR/p70S6K signaling pathway.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Medical Laboratory Technology
Hyun-Ki Kim, Jinyoung Hong, Sunyoung Ahn, Woochang Lee, Sail Chun, Won-Ki Min
Summary: The study found that in the general population, high levels of sdLDL-C are associated with high levels of oxLDL. However, the applicability of the equation for estimating sdLDL-C developed from the general population is limited in patients receiving DM treatment.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Chemistry, Analytical
Soemwit Khongwichit, Piyawut Swangphon, Natthaphon Nanakorn, Aekkaraj Nualla-ong, Kiattawee Choowongkomon, Peter A. Lieberzeit, Suticha Chunta
Summary: In this study, a simple colorimetric assay was developed for sensitive and specific determination of oxidized low-density lipoprotein (oxLDL) using a selective aptamer coupled with salt-induced gold nanoparticle aggregation. The assay showed a linear response to oxLDL in the range of 0.002 to 0.5 μmol/L, with high selectivity and accurate recovery. When applied to artificial serum, the assay exhibited excellent correlation with conventional thiobarbituric acid reactive substances (TBARS), providing a rapid and convenient alternative for oxLDL detection.
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Regina L. Binz, Rupak Pathak
Summary: This study investigated the cytogenetic integrity of primary human umbilical vein endothelial cells (HUVECs) and found that approximately 50% of the cells have a deletion of the Xq terminal region. Additionally, a similar Xq deletion was identified in the daughter cell line generated by fusing HUVECs with A549 cells.
