Article
Plant Sciences
Hyun Ji Eo, Jun Hyuk Jang, Gwang Hun Park
Summary: Berchemia floribunda (BF), a plant from Rhamnaceae, known for its antioxidant and whitening effects, was studied for its anti-inflammatory properties in this research. The leaves extract (BR-L) showed strong anti-inflammatory activity by inhibiting NO production and suppressing pro-inflammatory mediators in LPS-induced cells. BR-L also demonstrated potential in inhibiting NF-kappa B activation and MAPKs phosphorylation. These findings suggest the potential of BR-L as a candidate for new anti-inflammatory drugs against acute and chronic inflammatory disorders.
Article
Plant Sciences
Yuangeng Li, Ping Yu, Wenwen Fu, Lijian Cai, Ying Yu, Zhiqiang Feng, Yaozhen Wang, Fuyuan Zhang, Xiaofeng Yu, Huali Xu, Dayun Sui
Summary: The study evaluated the combined application of ginseng, astragalus, and oxymatrine on immune enhancement, finding that it significantly ameliorated immunosuppression in mice and stimulated immune activity at the cellular level.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Changkai Zhou, Jing Gao, Hongyan Ji, Wenjing Li, Xiaomin Xing, Donghua Liu, Qie Guo, Lihua Zhou, Fanbo Jing
Summary: The study showed that BAC exhibits anti-inflammatory effects by inhibiting TLR-induced MAPK and NF-kappa B pathways, indicating its potential use in treating inflammatory diseases.
Article
Food Science & Technology
Mingju Feng, Xiaoya Wang, Hua Xiong, Tingting Qiu, Hua Zhang, Fanghua Guo, Li Jiang, Yong Sun
Summary: The study revealed that selenium-enriched brown rice protein hydrolysates with 1.0-3.5 kDa peptide fractions have anti-inflammatory properties, effectively inhibiting the production of nitric oxide, prostaglandin, and pro-inflammatory cytokines. Additionally, these peptide fractions can suppress the expression of related proteins and block the phosphorylation of key signal proteins.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Jaejin Shin, Leo Sungwong Choi, Hyun Ju Jeon, Hyeong Min Lee, Sang Hyo Kim, Kwan-Woo Kim, Wonmin Ko, Hyuncheol Oh, Hyung Soon Park
Summary: This study investigated the anti-inflammatory effects of synthetic glabridin derivatives in LPS-stimulated macrophages. The derivatives suppressed the production of pro-inflammatory factors and inhibited the activation of MAPKs and NF-kappa B pathways. These findings suggest that glabridin derivatives may be potential therapeutics for inflammatory diseases.
Article
Pharmacology & Pharmacy
Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Summary: The study demonstrates that SVHRP can inhibit neuroinflammation and microglia activation, potentially explaining the therapeutic effects of BmK-derived materials and suggesting that BmK venom could be a potential source for CNS drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Orapin Insuan, Phornphimon Janchai, Benchaluk Thongchuai, Rujirek Chaiwongsa, Supaporn Khamchun, Somphot Saoin, Wimonrut Insuan, Peraphan Pothacharoen, Waraporn Apiwatanapiwat, Antika Boondaeng, Pilanee Vaithanomsat
Summary: The study found that bromelain can inhibit LPS-induced inflammatory responses, reduce the production of inflammatory cytokines, and achieve anti-inflammatory effects by regulating the expression of iNOS and COX-2, with purified rhizome bromelain showing stronger inhibitory effects than crude bromelain in RAW264.7 cells.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Applied
Yulin Wu, Jun Liu, Huili Hao, Lianmei Hu, Xiaoyong Zhang, Lianxiang Luo, Jincheng Zeng, Wei Zhang, Io Nam Wong, Riming Huang
Summary: Investigation on Caulerpa chemnitzia polysaccharides led to the discovery of a new polysaccharide (CCP) with immunomodulatory effects, potentially acting through the activation of NF-kappa B signaling pathway and arachidonic acid metabolism pathway.
Review
Immunology
Fang He, Xiaoyan Wu, Qingzhuo Zhang, Yikun Li, Yuyi Ye, Pan Li, Shuai Chen, Yuanyi Peng, Rudiger Hardeland, Yaoyao Xia
Summary: Melatonin exhibits antibacterial effects on various pathogenic bacteria in animals and plants, acting through multiple mechanisms such as direct actions at high concentrations, activation of hosts' defense mechanisms, attenuation of inflammation, and modulation of signaling pathways. Its protective functions involve inhibition of reactive oxygen and nitrogen species, detoxification, and protection against mitochondrial damage, suggesting melatonin as a potential effective approach against bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yifan Zhang, Xiaoteng Feng, Min Du, Jie Ding, Ping Liu
Summary: The anti-inflammatory effect of Salvianolic acid B (Sal B) was explored in this study. It was found that Sal B can exert its effects by inhibiting the MAPKs/NF-kappa B signaling pathways, resulting in decreased serum lipid levels, attenuated inflammatory cytokines, and improved lipid accumulation in the aorta.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
Article
Plant Sciences
Zhuangwei Zhang, Shuoqi Jiang, Hengqun Tian, Yu Zeng, Kang He, Lin Lin, Fangmiao Yu
Summary: The study aimed to investigate the anti-inflammatory effects of Nymphaea hybrida ethanol extract and its polar fractions. The results showed that the ethyl acetate fraction of NHE exhibited significant inhibitory effects on inflammation by suppressing the activation of NF-kappa B and MAPK pathways in LPS-induced inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Chuanqi Xie, Xinying Lin, Juwu Hu, Shufen Wang, Jing Wu, Wei Xiong, Lei Wu
Summary: This study investigated the immunomodulatory activities and mechanisms of Camellia oleifera fruit shell polysaccharide (CPS) in RAW264.7 macrophages. The results showed that CPS can stimulate the production of immune-related molecules and activate MAPKs and NF-KB signaling pathways in macrophages.
FOOD & NUTRITION RESEARCH
(2022)
Article
Cell Biology
Ting Zuo, Yinzi Yue, Xiaohui Wang, Huan Li, Shuai Yan
Summary: The study demonstrated that luteolin effectively improved colon health indicators and reduced inflammation levels in the affected areas by regulating the signaling pathways in the intestine to alleviate colitis.
Article
Pharmacology & Pharmacy
Xiaobing Lin, Junhan Zhang, Decai Fan, Jiqin Hou, Hao Wang, Lin Zhu, Ruina Tian, Xiaofei An, Ming Yan
Summary: Frutescone O was found to inhibit LPS-induced inflammation by suppressing the secretion of nitric oxide, inducing inducible nitric oxide synthase, and expression of pro-inflammatory cytokines. Additionally, Frutescone O exerts anti-inflammatory effects by interfering with NF-kappa B and MAPK signaling pathways, and inhibiting Myd88 and iNOS expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yongpeng Zou, Xing Luo, Yi Feng, Shaohong Fang, Jiangtian Tian, Bo Yu, Ji Li
Summary: Pyroptosis plays a crucial role in various diseases, and luteolin can prevent macrophage pyroptosis by inhibiting ROS production through Nrf2 activation and NF-κB inactivation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Food Science & Technology
Hui-Yuan Cheng, Li-Feng Li, Wen-Jie Wu, Quan-Wei Zhang, Man Liu, Tin-Long Wong, Hau-Yee Kong, Cheuk-Hei Lai, Wan-Rong Bao, Chu-Ying Huo, Hong-Ming Zheng, Qiu-Ke Hou, Jun Xu, Yan Zhou, Quan-Bin Han
Summary: An efficient qualitative and quantitative method for detecting agar in food products was developed, revealing a significant amount of commercial agar products to be adulterated with starch. This study confirmed the need for improved quality control for products labeled as or containing agar.
Article
Biochemistry & Molecular Biology
Wen-Jie Wu, Li-Feng Li, Hui-Yuan Cheng, Hau-Yee Fung, Hau-Yee Kong, Tin-Long Wong, Quan-Wei Zhang, Man Liu, Wan-Rong Bao, Chu-Ying Huo, Quan-Bin Han
Summary: This study analyzed both soluble and insoluble fractions to identify high-specificity peptides as qualitative markers for edible bird's nest (EBN) authentication. A qualitative and quantitative analytical method was successfully developed and validated, and it revealed that more than half of EBN products on the market were not consistent with the merchants' claims.
Article
Biochemistry & Molecular Biology
Wen-Jie Wu, Li-Feng Li, Hau-Yee Fung, Hui-Yuan Cheng, Hau-Yee Kong, Tin-Long Wong, Quan-Wei Zhang, Man Liu, Wan-Rong Bao, Chu-Ying Huo, Shangwei Guo, Haibin Liu, Xiangshan Zhou, Deng-Feng Gao, Quan-Bin Han
Summary: This study aimed to address the authentication issue of Ejiao using a database-independent strategy and identified 14 specific markers. A highly sensitive and selective quantitative analysis method was developed to confirm the specificity and accuracy of these markers in authenticating Ejiao.
Article
Chemistry, Applied
Quanwei Zhang, Shuang Hao, Lifeng Li, Man Liu, Chuying Huo, Wanrong Bao, Huiyuan Cheng, Hauyee Fung, Tinlong Wong, Wenjie Wu, Pingchung Leung, Shunchun Wang, Ting Li, Ge Zhang, Min Li, Zhongzhen Zhao, Wei Jia, Zhaoxiang Bian, Timothy Mitchison, Jingchao Zhang, Aiping Lyu, Quanbin Han
Summary: Radix Astragali polysaccharide (RAP) can enter Peyer's patches (PPs) and directly contact dendritic cells through the transportation by microfold (M) cells. This interesting transcytosis mechanism might apply to many other immunomodulatory polysaccharides.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Quanwei Zhang, Lifeng Li, Shuang Hao, Man Liu, Chuying Huo, Jianjun Wu, Hongbing Liu, Wanrong Bao, Hongming Zheng, Zhipeng Li, Huiyuan Cheng, Hauyee Fung, Tinlong Wong, Pingchung Leung, Shunchun Wang, Ting Li, Ge Zhang, Min Li, Zhongzhen Zhao, Wei Jia, Zhaoxiang Bian, Timothy Mitchison, Jingchao Zhang, Aiping Lyu, Quanbin Han, Handong Sun
Summary: The gut barrier poses a significant research challenge in studying orally bioactive polysaccharides in both in vivo and in vitro studies, particularly in understanding how these polysaccharides interact with related cells in vivo. This study examines the antitumor activity of a hyperbranched heteroglycan RAP from Radix Astragali, showing that its activity is immune-dependent and that it enters Peyer's patches to target dendritic cells and initiate antitumor immune responses. These findings provide insights into a lymphatic route for orally administered RAP to directly interact with immune cells and trigger antitumor immune responses, bridging the gap between in vitro and in vivo studies.
CARBOHYDRATE POLYMERS
(2022)
Article
Surgery
Marshall E. Kadin, John Morgan, Wei Wei, Zhihui Song, Yibin Yang
Summary: This study investigated the unique tumor pathology and growth regulation of Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) and explored potential targeted therapies. The results showed that CD30 expression is required for IL-13-STAT6 signaling and p38 MAPK activation in BIA-ALCL tumor cells. Inhibitors targeting the IL-13 pathway and p38 MAPK may be effective in treating BIA-ALCL patients.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Chemistry, Applied
Tin-Long Wong, Li-Feng Li, Ji-Xia Zhang, Quan-Wei Zhang, Xue-Ting Zhang, Li-Shuang Zhou, Hau-Yee Fung, Lei Feng, Hui -Yuan Cheng, Chu-Ying Huo, Man Liu, Wan-Rong Bao, Wen-Jie Wu, Cheuk-Hei Lai, Su -Ping Bai, Shao-Ping Nie, Pema-Tenzin Puno, Clara Bik-San Lau, Ping -Chung Leung, Quan-Bin Han, Han-Dong Sun
Summary: In this study, an oligosaccharide sequencing analysis was used to successfully correct the backbone of Dendrobium officinale polysaccharide (DOP) to mannan. This analysis involved producing oligosaccharide fragments through mild acid hydrolysis of DOP followed by p-aminobenzoic ethyl ester (ABEE) derivatization. The isolated and identified oligosaccharides with varied polymerization degrees (DP = 2-10) confirmed that the backbone of DOP is a beta-D-1,4-mannan. This oligosaccharide analysis is more straightforward and reliable compared to conventional methods.
FOOD HYDROCOLLOIDS
(2023)
Article
Oncology
Wei Wei, Zhihui Song, Masahiro Chiba, Wenjun Wu, Subin Jeong, Jing-Ping Zhang, Marshall E. Kadin, Masao Nakagawa, Yibin Yang
Summary: This study reveals the distinct roles of EP300 and CREBBP in ALCL and HL, with EP300 directly modulating the expression of oncogenes and immune-related molecules. The use of EP300/CREBBP inhibitors shows strong activities against ALCL and HL cells and inhibits tumor immune escape through PD-L1.
Article
Pharmacology & Pharmacy
Lijuan Yu, Chunhua Huang, Wei Yang, Zhenxing Ren, Lifeng Li, Huiyuan Cheng, Chengyuan Lin, Lixiang Zhai, Ziwan Ning, Hoileong Xavier Wong, Quanbin Han, Wei Jia, Zhaoxiang Bian, Ling Zhao
Summary: This study evaluated the effect of cinnamon extract on bowel symptoms in rat models of irritable bowel syndrome with diarrhea (IBS-D). It found that cinnamon extract reduced defecation frequency and visceral hyperalgesia in the rat models, and the efficacy was comparable to a positive drug. Furthermore, cinnamon extract directly inhibited the expression of Tph1 and controlled serotonin synthesis, providing a scientific viewpoint for the traditional use of cinnamon in treating IBS.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Shasha Cheng, Yi Kuang, Guodong Li, Jia Wu, Chung-Nga Ko, Wanhe Wang, Dik-Lung Ma, Min Ye, Chung-Hang Leung
Summary: This study reports the use of dehydroeburicoic acid (DEA) as a dual inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) and GSK3 beta, providing potential therapeutic strategies for alcoholic liver disease (ALD). DEA disrupts the Keap1-Nrf2 PPI and restores Nrf2 activity, leading to the activation of antioxidant genes. It also alleviates ethanol-induced mitochondrial dysfunction and exhibits minimal toxicity in the ALD cell model.
Review
Chemistry, Inorganic & Nuclear
Wanhe Wang, Jianhua Liu, Sang-Cuo Nao, Dik-Lung Ma, Jing Wang, Chung-Hang Leung
Summary: Changes in protein levels and types can indicate the occurrence of diseases, making differentially expressed proteins useful biomarkers for diagnosis and treatment. Luminescent iridium(III) complexes, especially affinity-based ones, with excellent optical properties, have gained attention in protein-based disease diagnostics. This review summarizes the current advances and future perspectives of affinity-based luminescent iridium(III) complexes for detecting disease-related proteins.
Article
Hematology
Zhihui Song, Wenjun Wu, Wei Wei, Wenming Xiao, Michelle Lei, Kathy Q. Cai, Da Wei Huang, Subin Jeong, Jing-Ping Zhang, Hongbo Wang, Marshall E. Kadin, Thomas A. Waldmann, Louis M. Staudt, Masao Nakagawa, Yibin Yang
Summary: This study revealed the critical role of the interleukin-1R (IL-1R) inflammatory pathway in pC-ALCL and its potential as a therapeutic target. The IL-1R pathway was found to promote JAK-STAT3 signaling activation and enhance the sensitivity of pC-ALCL cells to JAK inhibitors. The dual inhibitor pacritinib showed strong activities against pC ALK(-) ALCL in vitro and in vivo.
Article
Chemistry, Applied
Li-Feng Li, Hui-Yuan Cheng, Jun Lang, Tin-Long Wong, Ji-Xia Zhang, Wen-Jie Wu, Quan-Wei Zhang, Hau-Yee Kong, Check-Hei Lai, Hau-Yee Fung, Man Liu, Wan-Rong Bao, Chu-Ying Huo, Hong -Ming Zheng, Qiu-Ke Hou, Su -Ping Bai, Quan-Bin Han
Summary: In this study, a specific oligosaccharide marker for rapid authentication of edible bird's nest (EBN) was identified by comparing the saccharide profiles of EBN and adulterants. This marker, named BNM001, was characterized as Neu5Ac (2-3) Gal by MS and NMR spectra. The ABEE labeling of this marker improved the accuracy and sensitivity of LC-qTOF-MS quantitative analysis. The relative marker content was found to be associated with the quality of EBN products.
