Article
Chemistry, Multidisciplinary
Anil Kumar Sabhavath, Sarasija Madderla, Ravinder Dharavath, Vishnu Thumma, Gugulothu Thara, Srinivas Gundu, Ashok Dongamanti
Summary: This study describes a simple and convenient one-pot three-component method to synthesize 1,2,3-triazole-based 2,3-dihydrofuran derivatives. The method offers advantages such as high yield, short reaction time, and ease of operation, while using a green method and an eco-friendly catalyst. In vitro anticancer activity screening showed that most of the target compounds exhibited promising activity.
Article
Biochemistry & Molecular Biology
Jerome P. L. Ng, Yun Xiao Yun, Ali Adnan Nasim, Alessandra Gianoncelli, Betty Yuan Kwan Law, Giovanni Ribaudo, Vincent Kam Wai Wong, Paolo Coghi
Summary: A series of novel quinoline-triazole hybrid compounds were synthesized and evaluated for their interactions with different variants of SARS-CoV-2 and with the 3CLpro enzyme. Certain compounds showed promising interactions with viral variants and exhibited inhibitory effects on the 3CLpro enzyme.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Siva Kumar Gandham, Amit A. Kudale, Tejeswara Rao Allaka, Kalyani Chepuri, Anjali Jha
Summary: This study reports the design, synthesis, and molecular docking studies of tetrazolyl-1,2,3-triazole derivatives bearing pyrrolidine moiety. These compounds exhibit notable anticancer activity against various cancer cell lines. The results suggest their potential as lead compounds for the development of new anticancer agents.
MOLECULAR DIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Vincenzo Algieri, Paola Costanzo, Matteo Antonio Tallarida, Fabrizio Olivito, Antonio Jiritano, Giulia Fiorani, Francesca Peccati, Gonzalo Jimenez-Oses, Loredana Maiuolo, Antonio De Nino
Summary: This study reports the regioselective synthesis of a novel series of 1,5-disubstituted-1,2,3-triazole derivatives functionalized with pyrimidine nucleobases via 1,3-dipolar cycloaddition reaction. The synthesized compounds exhibited good pharmacokinetic properties and potential binding capabilities to viral and bacterial protein receptors based on molecular docking simulations.
Article
Chemistry, Physical
Kotyada Suryanarayana, Alice Rinky Robert, Nagaraju Kerru, Thangaiyan Pooventhiran, Renjith Thomas, Suresh Maddila, Sreekantha B. Jonnalagadda
Summary: A novel series of anti-cancer molecules with dinitrophenylpyrazole bearing triazole scaffolds were designed and synthesized, showing high potency growth inhibitory activity against cervical carcinoma and breast adenocarcinoma cell lines. Compound 9h demonstrated significant activity against both cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Manoj N. Kumar, Satheesh Kumar Nukala, Narasimha T. Swamy, M. Ravinder, Thupurani Murali Krishna, Sirassu Narsimha
Summary: In this study, novel fused benzothiazole-1,2,3-triazole hybrids were successfully synthesized through a CuI catalyzed method, showing promising anticancer activity against human cancer cell lines. The compounds 5i, 5n, 5o, 5 h and 5l demonstrated superior activity, supported by in vitro and in silico ADME studies as well as molecular docking studies on human gamma-tubulin receptor.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Fernanda Valerio Lopes, Pedro Henrique Fazza Stroppa, Juliane Aparecida Marinho, Roberta Reis Soares, Lara de Azevedo Alves, Priscila Vanessa Zabala Capriles Goliatt, Clarice Abramo, Adilson David da Silva
Summary: This study evaluated the antimalarial activity of triazole derivatives, with compound 5 showing promising potential for further development in antimalarial chemotherapy. In vitro and in vivo studies showed that compound 5 had significant parasitemia suppression and minimal cytotoxicity, making it a leading candidate for future research in antimalarial drug development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Pharmacology & Pharmacy
Jiahui Ye, Longfei Mao, Luoyijun Xie, Rongjun Zhang, Yulin Liu, Lizeng Peng, Jianxue Yang, Qingjiao Li, Miaomiao Yuan
Summary: Theophylline derivative compound d17 demonstrates strong antiproliferative activity against a variety of cancer cells, particularly the NSCLC cell lines H460 and A549. By altering the Bax/Bcl-2 ratio and downregulating phosphorylated Akt protein expression, compound d17 significantly induces cell apoptosis and shows minimal toxicity to normal hepatocytes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Meng Yin, Yongsheng Fang, Xiaotong Sun, Minggao Xue, Caimei Zhang, Zhiyun Zhu, Yamiao Meng, Lingmei Kong, Yi Yi Myint, Yan Li, Jingfeng Zhao, Xiaodong Yang
Summary: Three series of podophyllotoxin derivatives were synthesized with various nitrogen-containing heterocycles. The antitumor activity of these derivatives was evaluated against human tumor cell lines in vitro. The results showed that podophyllotoxin-imidazolium salts and podophyllotoxin-1,2,4-triazolium salts a1-a20 exhibited excellent cytotoxic activity, with a6 being the most potent compound. Podophyllotoxin-1,2,3-triazole derivatives b1-b5 showed medium cytotoxic activity, while podophyllotoxin-amine compounds c1-c3 displayed good cytotoxic activity. Further experiments revealed that compound a6 induced G2/M cell cycle arrest and apoptosis in HCT-116 cells.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Physical
C. P. Kaushik, Jyoti Sangwan, Raj Luxmi, Devinder Kumar, Deepak Kumar, Ashutosh Das, Ashwani Kumar, Dharmendra Singh
Summary: A series of anticancer and antioxidant compounds were synthesized through click chemistry method, with some compounds showing promising activity against cancer cell lines and strong antioxidant activity. Molecular docking studies revealed high binding affinities of certain compounds, suggesting their potential as future candidates for anticancer treatment. In-silico ADME studies also indicated good dispositional profile and patient compliance of the synthesized compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Aman Kumar, Kashmiri Lal, Nisha Poonia, Ashwani Kumar, Anil Kumar
Summary: A diverse series of imine linked 1,2,3-triazole hybrids were synthesized via Cu(I)-promoted click reaction, and their structures were characterized using various spectral techniques. Among them, 7d exhibited the highest antimicrobial activity against R. oryzae and S. aureus. Docking studies revealed that some triazole hybrids showed high potency towards E. coli DNA gyrase and C. albicans sterol 14-alpha demethylase.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Medicinal
C. B. Pradeep Kumar, B. S. Prathibha, K. N. N. Prasad, M. S. Raghu, M. K. Prashanth, B. K. Jayanna, Fahad A. Alharthi, S. Chandrasekhar, H. D. Revanasiddappa, K. Yogesh Kumar
Summary: Novel 1,2,3-triazole based imidazole derivatives were synthesized using Cu(I)-catalyzed cycloaddition of alkyne and azide reaction. The synthesized compounds showed potent in vitro antitubercular activity, particularly compounds 3d and 3e, and their binding interaction with human serum albumin was investigated.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Nayera W. Hassan, Ahmed Sabt, Maryam A. Z. El-Attar, Mikko Ora, Alaa El-Din A. Bekhit, Kikuko Amagase, Adnan A. Bekhit, Ahmed S. F. Belal, Perihan A. Elzahhar
Summary: According to WHO statistics, leishmaniasis is a neglected tropical disease that affects 700,000 to 1 million people annually. Researchers have designed and synthesized a new series of coumarin-1,2,3-triazole hybrid compounds that exhibit higher activity against L. major parasites than miltefosine. These compounds showed strong anti-leishmanial effects, with three of them demonstrating submicromolar potencies. Mechanistic studies revealed that folic and folinic acids reduced the anti-leishmanial effects of these compounds. Docking simulation studies supported the observed biological activities and highlighted the selectivity of these compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yue Ding, Ling Zhang, Song Yang, Zhong Li, Pei-Yi Wang
Summary: This study synthesized a new class of antimicrobial agents with significant growth inhibitory activity against various fungi, particularly showing promising results in in vivo trials against plant pathogens. The compounds also exhibited good antibacterial activity against phytopathogens, indicating their potential as lead compounds for highly bioactive antimicrobial substrates, especially as potential succinate dehydrogenase inhibitors.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Aman Kumar, Kashmiri Lal, Mohd Murtaza, Sundeep Jaglan, Yajat Rohila, Prashant Singh, Madhur Babu Singh, Kamlesh Kumari
Summary: A novel class of isatin-thiosemicarbazone-1,2,3-triazoles was designed and synthesized using the CuAAC approach for the development of new antimicrobial and antibiofilm agents. The synthesized hybrids were characterized and evaluated for their antimicrobial and antibiofilm efficacy. Triazole hybrid 8d showed the highest efficacy against E. coli and S. aureus, while compounds 8b, 8c, 8d, 8e, 9a, and terminal alkyne (10) significantly inhibited biofilm formation. Molecular docking, DFT calculations, and molecular dynamics studies were conducted to understand the structure-activity relationship and binding interactions of the synthesized hybrids.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Radhakrishnam Raju Ruddarraju, Adharvana Chari Murugulla, Ravindar Kotla, Muni Chandra Babu Tirumalasetty, Rajendra Wudayagiri, Shobha Donthabakthuni, Ravichandar Maroju, K. Baburao, Lakshmana Swamy Parasa
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Organic
Radhakrishnam Raju Ruddarraju, Adharvana Chari Murugulla, Ravindar Kotla, Muni Chandra Babu Tirumalasetty, Rajendra Wudayagiri, Shobha Donthabakthuni, Ravichandar Maroju, Sadhanadham Palle
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Baki Vijaya Bhaskar, Aluru Ram Mohan, Tirumalasetty Muni Chandra Babu, Sivarathri Siva Rajesh, Cherukupalle Bhuvaneswar, Thirunavakkarasu Sivaraman, Duvvuru Gunasekar, Wudayagiri Rajendra
PROCESS BIOCHEMISTRY
(2016)
Article
Chemistry, Medicinal
Tirumalasetty Muni, Chandra Babu, Aluru Rammohan, Vijaya Bhaskar Baki, Savita Devi, Duvvuru Gunasekar, Wudayagiri Rajendra
DRUG DESIGN DEVELOPMENT AND THERAPY
(2016)
Article
Chemistry, Medicinal
Baki Vijaya Bhaskar, Tirumalasetty Muni, Chandra Babu, Netala Vasudeva Reddy, Wudayagiri Rajendra
DRUG DESIGN DEVELOPMENT AND THERAPY
(2016)
Article
Chemistry, Multidisciplinary
Tirumalasetty Muni Chandra Babu, Sivarathri Siva Rajesh, Baki Vijaya Bhaskar, Savita Devi, Aluru Rammohan, Thirunavakkarasu Sivaraman, Wudayagiri Rajendra
Article
Chemistry, Medicinal
Sthanikam Siva Prasad, Krishnammagari Suresh Kumar, Soora Harinath Jayaprakash, Balam Satheesh Krishna, Chereddy Syama Sundar, Pasupuleti Visweswara Rao, Tirumalasetty Munichandra Babu, Wudayagiri Rajendra, Cirandur Suresh Reddy
ARCHIV DER PHARMAZIE
(2013)
Article
Chemistry, Medicinal
Pagadala Nataraj Sekhar, P. B. Kavi Kishor, P. K. Zubaidha, A. M. Hashmi, T. A. Kadam, Lakkireddy Anandareddy, Marc De Maeyer, K. Praveen Kumar, B. Vijaya Bhaskar, T. Munichandrababu, G. Jayasree, P. V. B. S. Narayana, G. Gyananath
MEDICINAL CHEMISTRY RESEARCH
(2011)
Article
Chemistry, Medicinal
Tirumalasetty Munichandrababu, Baki Vijaya Bhaskar, Sahukari Ravi, Cherukupalle Bhuvaneswar, Wudayagiri Rajendra
MEDICINAL CHEMISTRY RESEARCH
(2013)
Article
Biochemistry & Molecular Biology
Baki Vijaya Bhaskar, Tirumalasetty Muni Chandra Babu, Aluru Rammohan, Gui Yu Zheng, Grigory Zyryanov, Wei Gu
Article
Multidisciplinary Sciences
Baki Vijaya Bhaskar, Aluru Rammohan, Tirumalasetty Munichandra Babu, Gui Yu Zheng, Weibin Chen, Wudayagiri Rajendra, Grigory Zyryanov, Wei Gu
Summary: This study analyzed thirty dietary compounds on nine drug targets through in silico studies and found that compounds like silibinin and flavopiridol showed the highest binding energy with targets such as PI3K-alpha and PKC-eta, demonstrating broad spectrum anticancer activity. Pharmacophore modeling and database screening identified potential lead compounds, contributing to the development of novel anticancer agents.
SCIENTIFIC REPORTS
(2021)
Review
Biology
Mahmuda Begum, Mayank Choubey, Munichandra Babu Tirumalasetty, Shahida Arbee, Mohammad Mohabbulla Mohib, Md Wahiduzzaman, Mohammed A. Mamun, Mohammad Borhan Uddin, Mohammad Sarif Mohiuddin
Summary: Diabetes is a global health challenge, and adiponectin, as a hormone, plays a significant role in glucose metabolism and insulin sensitivity. In addition to its metabolic effects, adiponectin also has anti-inflammatory, anti-oxidative, and vasoprotective properties, making it a potential therapeutic target for diabetic complications.
Review
Biochemistry & Molecular Biology
Mayank Choubey, Munichandra B. Tirumalasetty, Nalini S. Bora, Puran S. Bora
Summary: This review explores the intricate relationship between adiponectin and ocular pathologies, highlighting its influence on retinal health and role in protecting against eye ailments. The review emphasizes the importance of adiponectin and its receptors in maintaining ocular homeostasis and potential therapeutic interventions for aging eye conditions. It also uncovers the interplay between adiponectin signaling pathways and age-related macular degeneration, providing insights for personalized treatments and preventative measures.