Article
Microbiology
Lea Weber, Anna Hagemann, Jila Kaltenhaeuser, Manuela Besser, Patrick Rockenfeller, Anja Ehrhardt, Ewa Stuermer, Hagen Sjard Bachmann
Summary: FTIs have been widely used in the treatment of various diseases, and studies have shown their potential effectiveness in the treatment of infectious diseases. The impact of FTIs on common human pathogens, especially on the geranyltranstransferase IspA, remains largely unknown.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Andreea Zubas, Alina Ghinet, Amaury Farce, Joelle Dubois, Elena Bicu
Summary: In this study, a chemical library of 49 cyanochalcones was designed as dual inhibitors of human farnesyltransferase and tubulin polymerization, two important targets in cancer chemotherapy. The compounds were synthesized and screened for their inhibitory effects on these targets and cancer cell growth. The most effective molecule identified was carbazole-cyanochalcone 3a, with better antitubulin activity compared to known inhibitors. The findings suggest that these dual inhibitors have great potential for clinical use in cancer treatment.
Review
Neurosciences
Bruno Lebrun, Manon Barbot, Marie-Christine Tonon, Vincent Prevot, Jerome Leprince, Jean-Denis Troadec
Summary: Neuroglial interactions and endozepines play crucial roles in the regulation of energy balance, particularly at the hypothalamic level. The actions of endozepines are complex, with both central anorexigenic effects and potential peripheral orexigenic effects.
Article
Pharmacology & Pharmacy
Yifei Ma, Tianao Yan, Fengshuo Xu, Jiachun Ding, Bao Yang, Qingyong Ma, Zheng Wu, Jun Lyu, Zheng Wang
Summary: A study on the association between HSA infusion and outcomes of acute pancreatitis patients in ICU found that HSA infusion did not benefit in-hospital prognosis and was associated with prolonged hospital and ICU duration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Christina L. Hutson, Ashley Kondas, Jana M. Ritter, Zachary Reed, Sharon Dietz Ostergaard, Clint N. Morgan, Nadia Gallardo-Romero, Cassandra Tansey, Matthew R. Mauldin, Johanna S. Salzer, Christine M. Hughes, Cynthia S. Goldsmith, Darin Carroll, Victoria A. Olson
Summary: Research has found that three humanized mice strains are highly susceptible to VARV infection, establishing the first small animal model. Following a VARV challenge mimicking human smallpox transmission, the virus spread systemically within the humanized mice similar to the course of human smallpox, facilitating testing of medical countermeasures.
Editorial Material
Biology
Alexandre Faille, Alan J. Warren
Summary: Understanding how streptomycin binds to the small subunit of the mitoribosome may aid in the development of less toxic derivatives of this antibiotic.
Review
Oncology
Shengye Jin, Qin Wang, Hao Wu, Da Pang, Shouping Xu
Summary: Biological therapy, particularly oncolytic viruses (OVs), has shown promising therapeutic effects in various cancers, including triple negative breast cancer (TNBC). TNBC, lacking conventional treatment targets, benefits from the emerging concept of OVs for potential treatment options.
BIOMARKER RESEARCH
(2021)
Review
Health Care Sciences & Services
Vincenzo Ricci, Teresa Fabozzi, Maria Anna Bareschino, Emiddio Barletta, Domenico Germano, Immacolata Paciolla, Vincenza Tinessa, Antonio Maria Grimaldi
Summary: This review summarizes the genetic and epigenetic architecture of metastatic pancreatic cancer and discusses the molecular pathology and molecular targets for treatment. The potential approach mentioned in this review may lead to the identification of a subset of patients with specific biological behaviors and treatment responses.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Simon W. Townsend, Alexis Hervais-Adelman
Summary: The study found that dogs and humans may segment speech in similar ways when listening to it.
Article
Business
Yi-Hou Huang, Woan-lih Liang, Quang-Thai Truong, Yanzhi Wang
Summary: This study found that U.S. listed firms with a higher percentage of old directors are more likely to engage in innovation activities, especially in companies with less experienced board members, low meeting frequency of boards, lower institutional ownership, CEO duality, and/or a less competitive product market.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2022)
Review
Cell Biology
Hui Liu, Kangdong Liu, Zigang Dong
Summary: PAKs, downstream effectors of Rho GTPase Cdc42 and Rac, play critical roles in various cellular processes and diseases. Understanding the structure, function, and molecular mechanisms of PAKs is important for future advancements in disease treatment and drug discovery.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Oluwafunke R. Kolawole, Khosrow Kashfi
Summary: Acute inflammation is an adaptive host defense mechanism, but unresolved or chronic inflammation can lead to various maladies, including cancer. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin have been shown to reduce the risk and mortality of many cancers. Besides targeting cyclooxygenase-2 (COX-2), NSAIDs also affect other important targets, and specialized pro-resolving mediators (SPMs) promote the resolution of inflammation and tissue healing, showing potential in inhibiting cancer growth and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Michela Palleschi, Gianluca Tedaldi, Marianna Sirico, Alessandra Virga, Paola Ulivi, Ugo De Giorgi
Summary: PARP inhibitors are effective drugs for treating tumors with BRCA1/2 mutations, with potential applications in both monotherapy and combination therapy for breast cancer, showing essential clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Gabor Balazsi
Summary: The researchers propose a new type of antiviral drugs that efficiently cure infected cells and minimize the chance of resistance.
Review
Biochemistry & Molecular Biology
Katerina Honigova, Jiri Navratil, Barbora Peltanova, Hana Holcova Polanska, Martina Raudenska, Michal Masarik
Summary: Metabolic plasticity is an important characteristic of cancer cells in tumorigenesis, allowing them to reshape metabolic pathways to support increased energy demands. The selective pressures in the tumor microenvironment force cancer cells to adapt by reorganizing their metabolism. Understanding metabolic reprogramming is crucial for developing targeted therapies for cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Chemistry, Medicinal
Weiqiang Lu, Xue Yao, Ping Ouyang, Ningnin Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng, Jin Huang
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Analytical
Ya-Qian Wang, Meng-Yin Li, Hu Qiu, Chan Cao, Ming-Bo Wang, Xue-Yuan Wu, Jin Huang, Yi-Lun Ying, Yi-Tao Long
ANALYTICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Dang Wu, Lepeng Wang, Yanhong Yang, Jin Huang, Yuhua Hu, Yongwei Shu, Jingyu Zhang, Jing Zheng
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Chemistry, Medicinal
Emanuela Nizi, Alessio Sferrazza, Danilo Fabbrini, Valentina Nardi, Matteo Andreini, Rita Graziani, Nadia Gennari, Alberto Bresciani, Giacomo Paonessa, Steven Harper
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Biochemistry & Molecular Biology
Li Lang, Qian Hu, Jingyuan Wang, Zehui Liu, Jin Huang, Weiqiang Lu, Ying Huang
CHEMICAL BIOLOGY & DRUG DESIGN
(2018)
Article
Chemistry, Medicinal
Gui-Xiang Yang, Song-Lan Ge, Yan Wu, Jin Huang, Shi-Liang Li, Rui Wang, Lei Ma
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Hematology
Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Weiqiang Lu, Jin Huang
Article
Pharmacology & Pharmacy
Zengrui Wu, Weiqiang Lu, Weiwei Yu, Tianduanyi Wang, Weihua Li, Guixia Liu, Hankun Zhang, Xiufeng Pang, Jin Huang, Mingyao Liu, Feixiong Cheng, Yun Tang
PHARMACOLOGICAL RESEARCH
(2018)
Article
Hematology
Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Weiqiang Lu, Jin Huang
Article
Chemistry, Multidisciplinary
Ya-Qian Wang, Chan Cao, Yi-Lun Ying, Shuang Li, Ming-Bo Wang, Jin Huang, Yi-Tao Long
Article
Pharmacology & Pharmacy
Jiange Qiu, Qianqian Li, Katherine A. Bell, Xue Yao, Yifeng Du, Erik Zhang, Jane J. Yu, Ying Yu, Zhi Shi, Jianxiong Jiang
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Arnab Dawn, Xue Yao, Ying Yu, Jianxiong Jiang, Harshita Kumari
SUPRAMOLECULAR CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Feixiong Cheng, Weiqiang Lu, Chuang Liu, Jiansong Fang, Yuan Hou, Diane E. Handy, Ruisheng Wang, Yuzheng Zhao, Yi Yang, Jin Huang, David E. Hill, Marc Vidal, Charis Eng, Joseph Loscalzo
NATURE COMMUNICATIONS
(2019)
Review
Biochemistry & Molecular Biology
Xue Yao, Sandro Matosevic
Summary: NK cell-based cell therapy shows promise in treating malignancies, but inadequate infiltration of therapeutic NK cells into solid tumors remains a challenge. Chemokine networks are essential in driving the intratumoral infiltration of NK cells, with chemokine receptors such as CCR2, CCR5, CCR7, CXCR3, and CX3CR1 playing significant roles.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Li Liu, Wanqi Wang, Jin Huang, Zhenjiang Zhao, Honglin Li, Yufang Xu