期刊
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncom.2017.00069
关键词
synaptic inhibition and excitation; quadratic integrate-and-fire model; Ornstein-Uhlenbeck process; oversampling method; spinal motoneurons; intracellular recordings of membrane potentials; maximum likelihood estimation; intrinsic currents
资金
- MCYT/FEDER [MTM2014-54275-P]
- Obra Social la Caixa
- Government of Catalonia [2014-SGR-504]
- Spanish Ministry of Economy and Competitiveness/FEDER [MTM2015-71509-C2-2-R]
- Danish Council for Independent Research Medical Sciences
Subthreshold fluctuations in neuronal membrane potential traces contain nonlinear components, and employing nonlinear models might improve the statistical inference. We propose a new strategy to estimate synaptic conductances, which has been tested using in silico data and applied to in vivo recordings. The model is constructed to capture the nonlinearities caused by subthreshold activated currents, and the estimation procedure can discern between excitatory and inhibitory conductances using only one membrane potential trace. More precisely, we perform second order approximations of biophysical models to capture the subthreshold nonlinearities, resulting in quadratic integrate-and-fire models, and apply approximate maximum likelihood estimation where we only suppose that conductances are stationary in a 50-100 ms time window. The results show an improvement compared to existent procedures for the models tested here.
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