期刊
FRONTIERS IN NEURAL CIRCUITS
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2017.00033
关键词
pontine gray nuclei; reticulotegmental nuclei; precerebellar system; cortico-ponto-cerebellar circuitry; Hox genes
资金
- Swiss National Science Foundation [P2BSP3_148629, 31003A_149573]
- EU FP7 Marie Curie Zukunftskolleg Incoming Fellowship Program [291784]
- Deutsche Forschungsgemeinschaft (DFG) [KR 4670/2-1]
- Young Scholar Fund of the University of Konstanz
- Elite Program for Postdocs of the BadenWurttemberg Stiftung
- Novartis Research Foundation
- Swiss National Science Foundation (SNF) [31003A_149573, P2BSP3_148629] Funding Source: Swiss National Science Foundation (SNF)
The pontine nuclei (PN) are the largest of the precerebellar nuclei, neuronal assemblies in the hindbrain providing principal input to the cerebellum. The PN are predominantly innervated by the cerebral cortex and project as mossy fibers to the cerebellar hemispheres. Here, we comprehensively review the development of the PN from specification to migration, nucleogenesis and circuit formation. PN neurons originate at the posterior rhombic lip and migrate tangentially crossing several rhombomere derived territories to reach their final position in ventral part of the pons. The developing PN provide a classical example of tangential neuronal migration and a study system for understanding its molecular underpinnings. We anticipate that understanding the mechanisms of PN migration and assembly will also permit a deeper understanding of the molecular and cellular basis of cortico-cerebellar circuit formation and function.
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