Article
Neurosciences
Masayasu Okada, Yosuke Kawagoe, Yuta Sato, Motohiro Nozumi, Yuya Ishikawa, Atsushi Tamada, Hiroyuki Yamazaki, Yuko Sekino, Yonehiro Kanemura, Yohei Shinmyo, Hiroshi Kawasaki, Naoko Kaneko, Kazunobu Sawamoto, Yukihiko Fujii, Michihiro Igarashi
Summary: GAP-43 is a vertebrate neuron-specific protein strongly associated with axon growth and regeneration. The phosphorylation site T172 is widely conserved across a range of mammals, making it a potential new candidate molecular marker for growing axons.
Article
Multidisciplinary Sciences
P. Robin, T. Emmerich, A. Ismail, A. Nigues, Y. You, G. -H. Nam, A. Keerthi, A. Siria, A. K. Geim, B. Radha, L. Bocquet
Summary: Experiments reveal the emergence of memory in the transport of electrolytes across nanoscale channels, which lays the foundation for biomimetic computations.
Article
Biology
Kwun Nok Mimi Man, Peter Bartels, Peter B. Henderson, Karam Kim, Mei Shi, Mingxu Zhang, Sheng-Yang Ho, Madeline Nieves-Cintron, Manuel F. Navedo, Mary C. Horne, Johannes W. Hell
Summary: The cellular mechanisms by which norepinephrine regulates behaviors in the brain remain unknown. This study identifies the L-type Ca2+ channel Ca(V)1.2 as a major target for alpha(1)-adrenergic receptors (ARs) in the hippocampus. Activation of alpha(1)AR signaling enhances LTCC activity through the PKC-Pyk2-Src pathway, suggesting that Ca(V)1.2 is a central conduit for norepinephrine signaling. Inhibition of Pyk2 and Src blocks hippocampal long-term potentiation (LTP), indicating that the enhancement of Ca(V)1.2 activity through alpha(1)AR-Pyk2-Src signaling regulates synaptic strength.
Review
Cardiac & Cardiovascular Systems
Renju Pun, Michael H. H. Kim, Brian J. J. North
Summary: Intercellular communication in cardiomyocytes relies on Connexin 43 (Cx43) gap junction channels and hemichannels. The phosphorylation of Cx43 at Serine-368 (S368) by Protein Kinase C (PKC) isozymes affects the function and stability of Cx43, leading to altered intercellular communication. This review highlights the molecular and cellular mechanisms of PKC-mediated Cx43 phosphorylation and discusses its implications in various cardiac diseases, as well as the potential therapeutic targets.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Hanna Dumanska, Nikolai Veselovsky
Summary: The study found that hypoxia leads to long-term potentiation of NMDA neurotransmission, and the protein kinase C (PKC) signaling pathway plays an important role in this process. It was discovered that adding a PKC inhibitor can block the induction of long-term potentiation, but cannot reverse the shortening of current kinetics. These findings provide insights into the prevention and treatment of hypoxic injuries and the underlying mechanisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Xiumin Chen, Yuko Fukata, Masaki Fukata, Roger A. Nicoll
Summary: This study reveals the essential role of the MAGUK family of synaptic scaffolding proteins in LTP, with PSD-95 requiring binding to ADAM22 for synaptic transmission enhancement. Additionally, an alternative pathway involving SAP102 is proposed, independent of ADAM22.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Haden L. Scott, Dima Bolmatov, Peter T. Podar, Zening Liu, Jacob J. Kinnun, Benjamin Doughty, Ralph Lydic, Robert L. Sacci, C. Patrick Collier, John Katsaras
Summary: This study demonstrates that droplet interface bilayers (DIBs) composed of lipids can exhibit persistent synaptic plasticity, characterized by long-term potentiation (LTP) and capacitive energy storage. The time scales for the physical changes associated with LTP are longer than previous short-term synaptic plasticity studies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Alen Eapen, Diego Fernandez-Fernandez, John Georgiou, Zuner A. Bortolotto, Stafford Lightman, David E. Jane, Arturas Volianskis, Graham L. Collingridge
Summary: The study demonstrates the involvement of GluN2D-containing NMDARs in both short-term potentiation (STP) and long-term potentiation (LTP) in the mouse hippocampus, highlighting the important role of GluN2D subunits in synaptic plasticity.
Article
Multidisciplinary Sciences
Emmanouela Kallergi, Akrivi-Dimitra Daskalaki, Angeliki Kolaxi, Come Camus, Evangelia Ioannou, Valentina Mercaldo, Per Haberkant, Frank Stein, Kyriaki Sidiropoulou, Yannis Dalezios, Mikhail M. Savitski, Claudia Bagni, Daniel Choquet, Eric Hosy, Vassiliki Nikoletopoulou
Summary: Autophagy is required for pruning dendritic spines and long-term depression (LTD), a major form of synaptic plasticity. LTD induces the biogenesis of autophagic vesicles in dendrites to facilitate the degradation of postsynaptic proteins. Autophagy plays a crucial role in dendritic spine pruning and synaptic plasticity.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Lorenzo Alibardi
Summary: This study demonstrates the formation of a glial-connective tissue bridge that reconnects the rostral and caudal stumps of the transected spinal cord in lizards. It also reveals a limited recovery of hindlimb movements within 1-3 months post-injury. The presence of numerous neurons and a small number of regenerating axons suggests their involvement in activating neural circuits for the recovery of hind-limb movements.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Musa Iyiola Ajibola, Jei-Wei Wu, Wahab Imam Abdulmajeed, Cheng-Chang Lien
Summary: The study demonstrates that subcortical input from the SuM selectively regulates the activities of different DG neurons through distinct synaptic mechanisms in mice. While SuM activation leads to synaptic excitation and inhibition in all post-synaptic cells, the ratio of these components varies depending on cell type. Specifically, dendrite-targeting interneurons primarily receive synaptic excitation, soma-targeting interneurons and granule cells mainly receive synaptic inhibition.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tatyana Y. Postnikova, Sergey L. Malkin, Maria Zakharova, Ilya Smolensky, Olga E. Zubareva, Aleksey Zaitsev
Summary: Disruption of glutamate clearance in the synaptic cleft can lead to synaptic dysfunction and neurological diseases, potentially causing excitotoxicity. Increased glutamate clearance has been shown to reduce long-term synaptic potentiation (LTP). Treatment with the enhancer of glutamate transporter 1 expression, ceftriaxone, weakened LTP in the hippocampus of young rats, likely due to reduced spillover of glutamate leading to decreased activation of synapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Michelle C. Stone, Abigail S. Mauger, Melissa M. Rolls
Summary: Axon regeneration is crucial for maintaining the lifelong function of neurons. This study investigates the ability of ciliated sensory neurons to grow new axons after proximal axon injury. The results show that these neurons are not intrinsically limited in their ability to regenerate axons, and neurites can regrow in various forms after injury. The findings shed light on the flexibility and potential of ciliated sensory neurons in responding to axon damage.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Neurosciences
Jiyeon Seo, Hongik Hwang, Yuri Choi, Sunmin Jung, Jung-Hwa Hong, Bong-June Yoon, Hyewhon Rhim, Mikyoung Park
Summary: Many psychiatric disorders are associated with deficits in cognitive functions and synaptic plasticity, which are linked to abnormal lipid modifications of neuronal proteins. Cyclin Y (CCNY), located in the postsynaptic compartment, plays an inhibitory role in synaptic plasticity and spatial learning through myristoylation and palmitoylation.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Cell & Tissue Engineering
Deborah Pre, Alexander T. Wooten, Steven Biesmans, Sandy Hinckley, Haowen Zhou, Sean P. Sherman, Priyanka Kakad, Jeffrey Gearhart, Anne G. Bang
Summary: Impairment of long-term potentiation (LTP) is a common feature in neurological disorders. Researchers have developed a multi-electrode array-based assay to study chemically induced LTP (cLTP) in human induced pluripotent stem cells (hiPSCs) derived from midbrain dopaminergic (DA) and cortical neuronal populations. The cLTP-MEA assay platform allows for analysis of the late phases of LTP, detection of molecular changes, and discovery of phenotype on hiPSC-derived neurons.
Article
Rehabilitation
Manuel Herrador-Colmenero, Victor Segura-Jimenez, Inmaculada C. Alvarez-Gallardo, Alberto Soriano-Maldonado, Daniel Camiletti-Moiron, Manuel Delgado-Fernandez, Palma Chillon
Summary: The study showed a positive association between active commuting and higher levels of physical activity and less sedentary time among younger women with fibromyalgia, but no such relationship was observed in the older group.
DISABILITY AND REHABILITATION
(2022)
Article
Sport Sciences
Nuria Marin-Jimenez, Jose Castro-Pinero, Maria Rodriguez-Ayllon, Alba Marchan-Rubio, Manuel Delgado-Fernandez, Virginia A. Aparicio
Summary: The study found that better self-reported physical fitness was associated with lower levels of depressive symptoms and anxiety during pregnancy. Specifically, at 16 weeks, better overall physical fitness was related to fewer depressive symptoms, better muscular strength was related to lower anxiety levels; at 34 weeks, better overall physical fitness and speed-agility were related to lower anxiety levels, and better cardiorespiratory fitness was related to lower anxiety levels. Screening physical fitness may help reduce the risk of depression and anxiety and improve the mental health-related quality of life during pregnancy.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Health Care Sciences & Services
Octavio Luque-Reca, Alberto Soriano-Maldonado, Blanca Gavilan-Carrera, Pedro Acosta-Manzano, Patrocinio Ariza-Vega, Gustavo A. Reyes del Paso, Inmaculada C. Alvarez-Gallardo, Fernando Estevez-Lopez
Summary: This study examined the longitudinal associations between physical fitness and affect with depression, anxiety, and life satisfaction in women with fibromyalgia. The findings revealed that reducing negative affect was associated with decreased depression and anxiety, as well as increased life satisfaction. Additionally, improvements in positive affect were linked to reduced anxiety and higher life satisfaction, while enhancing physical fitness was related to higher life satisfaction.
QUALITY OF LIFE RESEARCH
(2022)
Article
Rheumatology
Fernando Estevez-Lopez, Juan M. Guerrero-Gonzalez, Diego Salazar-Tortosa, Daniel Camiletti-Moiron, Blanca Gavilan-Carrera, Virginia A. Aparicio, Pedro Acosta-Manzano, Inmaculada C. Alvarez-Gallardo, Victor Segura-Jimenez, Alberto Soriano-Maldonado, Rinie Geenen, Manuel Delgado-Fernandez, Luis J. Martinez-Gonzalez, Jonatan R. Ruiz, Maria J. Alvarez-Cubero
Summary: This study found that the HTR2A gene (individually), COMT and OPRM1 gene-gene interaction, and the interactions of sedentary behavior with ADRA1A, CHMP1A, COMT and SCN9A genes were associated with pain-related outcomes in women with FM. Overall, the findings of this study indicate a modest contribution of genetics and gene-sedentary behavior interaction to pain and pain catastrophizing in women with FM.
Article
Nutrition & Dietetics
Pedro Acosta-Manzano, Francisco M. Acosta, Marta Flor-Alemany, Blanca Gavilan-Carrera, Manuel Delgado-Fernandez, Laura Baena-Garcia, Victor Segura-Jimenez, Virginia A. Aparicio
Summary: Physical fitness, especially muscle strength and cardiorespiratory fitness, plays an important role in maternal-fetal metabolism during pregnancy. Having good physical fitness can reduce the risk of cardiometabolic abnormalities and protect against maternal cardiometabolic risk. Therefore, maintaining good physical fitness and normal weight before and during early pregnancy is crucial.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2022)
Review
Neurosciences
Brendan Hoffe, Matthew R. Holahan
Summary: Understanding the biological response of brain tissue to biomechanical strain is crucial in understanding the sequela of brain injury. The time after impact can be divided into four phases: hyperacute, acute, subacute, and chronic. Dendritic spines react to excitotoxic conditions after an impact, leading to a shift in morphology and potentially detrimental consequences on cellular signaling and survival. Studying the cellular mechanisms in the hyperacute phase can help understand the pathology and develop effective therapeutics.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Miguel Martin-Matillas, Dinalrilan Rocha-Silva, Abel Plaza-Florido, Manuel Delgado-Fernandez, Amelia Marti, Pilar De Miguel-Etayo, Luis A. Moreno, Ascension Marcos, Cristina Campoy
Summary: This study investigated the determinants of cardiometabolic risk changes in overweight/obese adolescents and found that body weight changes were the most important predictor.
Article
Rehabilitation
Blanca Gavilan-Carrera, Manuel Delgado-Fernandez, Eugenio Sierra-Nieto, Pedro Acosta-Manzano, Milkana Borges-Cosic, Alberto Soriano-Maldonado, Victor Segura-Jimenez
Summary: This study found that higher levels of total and prolonged sedentary time are associated with greater depressive symptoms and state anxiety in women with fibromyalgia. Moderate-to-vigorous physical activity did not modify these associations, although physical fitness could play a protective role specially for state anxiety.
DISABILITY AND REHABILITATION
(2023)
Article
Sport Sciences
Blanca Gavilan-Carrera, Manuel Delgado-Fernandez, Inmaculada C. Alvarez-Gallardo, Pedro Acosta-Manzano, Milkana Borges-Cosic, Fernando Estevez-Lopez, Alberto Soriano-Maldonado, Ana Carbonell-Baeza, Virginia A. Aparicio, Victor Segura-Jimenez
Summary: The objective of this study was to analyze the predictive value of baseline and changes in sedentary time and physical activity on pain, disease impact, and health-related quality of life in women with fibromyalgia. Results showed that variables such as pressure pain threshold, sedentary time, light physical activity, and moderate-to-vigorous physical activity worsened over 5 years, while self-reported outcomes improved. Reducing sedentary time and increasing light physical activity were associated with better outcomes at 5-year follow-up, and increasing moderate-to-vigorous physical activity was associated with less pain and better outcomes at both 2- and 5-year follow-up.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Review
Neurosciences
Dennis G. Chan, Katelyn Ventura, Ally Villeneuve, Paul Du Bois, Matthew R. Holahan
Summary: The microbiota in the gut may play a role in the development and progression of Parkinson's disease by contributing to gastrointestinal inflammation. The gut-brain axis is an important communication pathway between the gut microbiota and the central nervous system. Targeting the imbalance in the gut microbiota may alleviate prodromal symptoms and prevent the spread of pathological proteins associated with Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Behavioral Sciences
Teresa Maletta, Michael Palummieri, Jeff Correa, Matthew R. Holahan
Summary: Social memory involves the ability to recognize social contacts that have been previously encountered. The CA2 region of the hippocampus is important for social memory, and dysfunction in this area can lead to impairments. This study found that exposure to an unrelated adult male during preadolescence resulted in social memory deficits in rats during the postadolescent period.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Rehabilitation
Blanca Gavilan-Carrera, Milkana Borges-Cosic, Inmaculada C. Alvarez-Gallardo, Alberto Soriano-Maldonado, Pedro Acosta-Manzano, Daniel Camiletti-Moiron, Ana Carbonell-Baeza, Antonio J. Casimiro, Maria Jose Girela-Rejon, Brian Walitt, Fernando Estevez-Lopez
Summary: A 24-week land and water-based exercise program can effectively reduce fatigue and improve sleep quality in women with fibromyalgia, although these benefits are not sustained after exercise cessation.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Sport Sciences
Nuria Marin-Jimenez, Sandra Sanchez-Parente, Pablo Exposito-Carrillo, Jose Jimenez-Iglesias, Inmaculada C. Alvarez-Gallardo, Magdalena Cuenca-Garcia, Jose Castro-Pinero
Summary: This study aimed to analyze the criterion-related validity and reliability of fitness field tests for evaluating cardiorespiratory fitness in adults, by sex, age, and physical activity level. The results showed a high correlation between the 2-km walk test and the 20-m SRT with the measured VO2max. Both tests and estimated VO2max equations exhibited high test-retest reliability.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Chemistry, Multidisciplinary
Roslyn S. Massey, Erin M. McConnell, Dennis Chan, Matthew R. Holahan, Maria C. DeRosa, Ravi Prakash
Summary: Parkinson's disease affects over 1 million people in the US and 8.5 million worldwide, but there is a lack of fast, pain-free, and effective screening methods. This study presents a lab prototype capable of quantifying alpha Syn aggregation in saliva, offering a label-free, fast, and reusable biosensor with good selectivity. The biosensors have a low limit of detection, extended linear range, and fully integrated microchannels, making them a promising platform for non-invasive point-of-care testing of PD.
Meeting Abstract
Neurosciences
Rami Hamati, Jessica Ahrens, Chidiebere Michael Iro, Matthew Holahan, Lauri Tuominen
BIOLOGICAL PSYCHIATRY
(2022)