期刊
ALZHEIMERS & DEMENTIA
卷 11, 期 9, 页码 1032-1040出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2014.07.159
关键词
Transcranial direct current stimulation; Mild cognitive impairment; Functional magnetic resonance imaging; Resting-state fMRI; Language; Aging
资金
- Australian Research Council [ARC FT120100608]
- Deutsche Forschungsgemeinschaft [379-8/1, 379-10/1, 379-11/1, DFG-Exc-257, 423/1-1]
- Bundesministerium fur Bildung und Forschung [FKZ0315673A, 01GY1144, 01EO0801]
- Else Kroner-Fresenius-Stiftung [2011-119]
Introduction: The long preclinical phase of Alzheimer's disease provides opportunities for potential disease-modifying interventions in prodromal stages such as mild cognitive impairment (MCI). Anodal transcranial direct current stimulation (anodal-tDCS), with its potential to enhance neuroplasticity, may allow improving cognition in MCI. Methods: In a double-blind, cross-over, sham-controlled study, anodal-tDCS was administered to the left inferior frontal cortex during task-related and resting-state functional magnetic resonance imaging (fMRI) to assess its impact on cognition and brain functions in MCI. Results: During sham stimulation, MCI patients produced fewer correct semantic-word-retrieval responses than matched healthy controls, which was associated with hyperactivity in bilateral prefrontal regions. Anodal-tDCS significantly improved performance to the level of controls, reduced task-related prefrontal hyperactivity and resulted in normalization of abnormal network configuration during resting-state fMRI. Discussion: Anodal-tDCS exerts beneficial effects on cognition and brain functions in MCI, thereby providing a framework to test whether repeated stimulation sessions may yield sustained reversal of cognitive deficits. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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