Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development

Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors

(2016) Lluís Cordón-Barris et al.   MOLECULAR AND CELLULAR BIOLOGY

PDK1–Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex

(2016) Yasuhiro Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division

(2016) Teruki Dainichi et al.   Cell Reports

Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration

(2015) Shanshan Cheng et al.   Scientific Reports

PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases

(2013) Mathéa Pietri et al.   NATURE MEDICINE

PDK1 regulates the generation of oligodendrocyte precursor cells at an early stage of mouse telencephalic development

(2012) Kenji Watatani et al.   GENES TO CELLS

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

CREB Binding Protein Is Required for Both Short-Term and Long-Term Memory Formation

(2010) G. Chen et al.   JOURNAL OF NEUROSCIENCE

PDK1 Regulates Vascular Remodeling and Promotes Epithelial-Mesenchymal Transition in Cardiac Development

(2010) Q. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

The Apical Complex Couples Cell Fate and Cell Survival to Cerebral Cortical Development

(2010) Seonhee Kim et al.   NEURON

Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice

(2010) Mary Wines-Samuelson et al.   PLoS One

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

(2009) N. Chalhoub et al.   GENES & DEVELOPMENT

Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration

(2009) K. Tabuchi et al.   JOURNAL OF NEUROSCIENCE

Requirement of 3-Phosphoinositide-Dependent Protein Kinase-1 for BDNF-Mediated Neuronal Survival

(2008) G. Kharebava et al.   JOURNAL OF NEUROSCIENCE