期刊
CHEMICAL SCIENCE
卷 8, 期 2, 页码 1002-1007出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc04371b
关键词
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资金
- NSERC
- Canadian Foundation for Innovation (CFI)
- FQRNT supported Centre for Green Chemistry and Catalysis
We describe here a tandem catalytic route to prepare imidazoles in a single operation from aryl iodides, imines and CO. The reaction involves a catalytic carbonylation of aryl halides with imines to form 1,3-dipoles, which undergo spontaneous 1,3-dipolar cycloaddition. Overall, this offers an alternative to coupling reactions to construct the (hetero) aryl-imidazole motif, where variation of the building blocks can allow the synthesis of broad families of imidazoles with independent control of all substituents.
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