The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors

Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus

(2016) Malvika Kaul et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Redefining the roles of the FtsZ-ring in bacterial cytokinesis

(2016) Jie Xiao et al.   CURRENT OPINION IN MICROBIOLOGY

Progress and prospects for small-molecule probes of bacterial imaging

(2016) Ozden Kocaoglu et al.   Nature Chemical Biology

Splitsville: structural and functional insights into the dynamic bacterial Z ring

(2016) Daniel P. Haeusser et al.   NATURE REVIEWS MICROBIOLOGY

Defining the rate-limiting processes of bacterial cytokinesis

(2016) Carla Coltharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connecting the dots of the bacterial cell cycle: Coordinating chromosome replication and segregation with cell division

(2016) Isabella V. Hajduk et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cytological Profile of Antibacterial FtsZ Inhibitors and Synthetic Peptide MciZ

(2016) Lidia Araújo-Bazán et al.   Frontiers in Microbiology

Beyond a Fluorescent Probe: Inhibition of Cell Division Protein FtsZ by mant-GTP Elucidated by NMR and Biochemical Approaches

(2015) Sonia Huecas et al.   ACS Chemical Biology

In VivoPharmacodynamic Evaluation of an FtsZ Inhibitor, TXA-709, and Its Active Metabolite, TXA-707, in a Murine Neutropenic Thigh Infection Model

(2015) Alexander J. Lepak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and EnhancedIn VivoEfficacy against Methicillin-Resistant Staphylococcus aureus

(2015) Malvika Kaul et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins

(2015) Rui Zhang et al.   CELL

A benzamide-dependent fts Z mutant reveals residues crucial for Z-ring assembly

(2015) David William Adams et al.   MOLECULAR MICROBIOLOGY

Remodeling of the Z-Ring Nanostructure during the Streptococcus pneumoniae Cell Cycle Revealed by Photoactivated Localization Microscopy

(2015) Maxime Jacq et al.   mBio

A Multi-layered Protein Network Stabilizes the Escherichia coli FtsZ-ring and Modulates Constriction Dynamics

(2015) Jackson Buss et al.   PLoS Genetics

Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action

(2014) Marta Artola et al.   ACS Chemical Biology

Bacterial cell division proteins as antibiotic targets

(2014) Tanneke den Blaauwen et al.   BIOORGANIC CHEMISTRY

3D-SIM Super-resolution of FtsZ and Its Membrane Tethers in Escherichia coli Cells

(2014) Veronica Wells Rowlett et al.   BIOPHYSICAL JOURNAL

Understanding Nucleotide-Regulated FtsZ Filament Dynamics and the Monomer Assembly Switch with Large-Scale Atomistic Simulations

(2014) Erney Ramírez-Aportela et al.   BIOPHYSICAL JOURNAL

The contribution of αβ-tubulin curvature to microtubule dynamics

(2014) Gary J. Brouhard et al.   JOURNAL OF CELL BIOLOGY

High throughput 3D super-resolution microscopy reveals Caulobacter crescentus in vivo Z-ring organization

(2014) S. J. Holden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of the ring formed by the tubulin homologue FtsZ in bacterial cell division

(2014) Piotr Szwedziak et al.   eLife

Synthetic Inhibitors of Bacterial Cell Division Targeting the GTP-Binding Site of FtsZ

(2013) Laura B. Ruiz-Avila et al.   ACS Chemical Biology

Organization of FtsZ Filaments in the Bacterial Division Ring Measured from Polarized Fluorescence Microscopy

(2013) Fangwei Si et al.   BIOPHYSICAL JOURNAL

Bacterial cell division as a target for new antibiotics

(2013) Peter Sass et al.   CURRENT OPINION IN MICROBIOLOGY

Interactions of Bacterial Cell Division Protein FtsZ with C8-Substituted Guanine Nucleotide Inhibitors. A Combined NMR, Biochemical and Molecular Modeling Perspective

(2013) Filipa Marcelo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The bacterial cell division proteins FtsA and FtsZ self-organize into dynamic cytoskeletal patterns

(2013) Martin Loose et al.   NATURE CELL BIOLOGY

Liposome division by a simple bacterial division machinery

(2013) M. Osawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural reorganization of the bacterial cell-division protein FtsZ fromStaphylococcus aureus

(2012) Takashi Matsui et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The physiology of bacterial cell division

(2012) Alexander J. F. Egan et al.   Annals of the New York Academy of Sciences

Three-Dimensional Super-Resolution Imaging of the Midplane Protein FtsZ in LiveCaulobacter crescentusCells Using Astigmatism

(2012) Julie S. Biteen et al.   CHEMPHYSCHEM

Bacterial cytokinesis: From Z ring to divisome

(2012) Joe Lutkenhaus et al.   Cytoskeleton

Mechanism of Action of the Cell-Division Inhibitor PC190723: Modulation of FtsZ Assembly Cooperativity

(2012) Nathaniel L. Elsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

3D-SIM Super Resolution Microscopy Reveals a Bead-Like Arrangement for FtsZ and the Division Machinery: Implications for Triggering Cytokinesis

(2012) Michael P. Strauss et al.   PLOS BIOLOGY

Targeting the Assembly of Bacterial Cell Division Protein FtsZ with Small Molecules

(2011) Claudia Schaffner-Barbero et al.   ACS Chemical Biology

Conformational Changes of FtsZ Reported by Tryptophan Mutants

(2011) Yaodong Chen et al.   BIOCHEMISTRY

Multiple effects of benzamide antibiotics on FtsZ function

(2011) David W. Adams et al.   MOLECULAR MICROBIOLOGY

The Antibacterial Cell Division Inhibitor PC190723 Is an FtsZ Polymer-stabilizing Agent That Induces Filament Assembly and Condensation

(2010) José M. Andreu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping Flexibility and the Assembly Switch of Cell Division Protein FtsZ by Computational and Mutational Approaches

(2010) Antonio J. Martín-Galiano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties

(2010) David J. Haydon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chrysophaentins A−H, Antibacterial Bisdiarylbutene Macrocycles That Inhibit the Bacterial Cell Division Protein FtsZ

(2010) Alberto Plaza et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FtsZ in Bacterial Cytokinesis: Cytoskeleton and Force Generator All in One

(2010) H. P. Erickson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

In Vivo Structure of the E. coli FtsZ-ring Revealed by Photoactivated Localization Microscopy (PALM)

(2010) Guo Fu et al.   PLoS One

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

(2008) Lloyd G. Czaplewski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polymerization and Bundling Kinetics of FtsZ Filaments

(2008) Ganhui Lan et al.   BIOPHYSICAL JOURNAL

Allosteric Models for Cooperative Polymerization of Linear Polymers

(2008) Emily R. Miraldi et al.   BIOPHYSICAL JOURNAL

Probing FtsZ and Tubulin with C8-Substituted GTP Analogs Reveals Differences in Their Nucleotide Binding Sites

(2008) Tilman Läppchen et al.   CHEMISTRY & BIOLOGY

Investigation of Regulation of FtsZ Assembly by SulA and Development of a Model for FtsZ Polymerization

(2008) A. Dajkovic et al.   JOURNAL OF BACTERIOLOGY

The lattice as allosteric effector: Structural studies of   - and  -tubulin clarify the role of GTP in microtubule assembly

(2008) L. M. Rice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

(2008) D. J. Haydon et al.   SCIENCE

Energetics and Geometry of FtsZ Polymers: Nucleated Self-Assembly of Single Protofilaments

(2007) Sonia Huecas et al.   BIOPHYSICAL JOURNAL