Article
Microbiology
Yana Igolkina, Valeriy Yakimenko, Artem Tikunov, Tamara Epikhina, Aleksey Tancev, Nina Tikunova, Vera Rar
Summary: The prevalence and genetic diversity of Rickettsia spp. were investigated in Ixodes apronophorus, Ixodes persulcatus, and Ixodes trianguliceps ticks from the same habitats in Western Siberia. Rickettsia helvetica was found in I. apronophorus, while Candidatus Rickettsia tarasevichiae dominated in I. persulcatus and I. trianguliceps were infected with Candidatus Rickettsia uralica, R. helvetica, and Ca. R. tarasevichiae. Phylogenetic analysis revealed the high genetic variability of R. helvetica.
Article
Infectious Diseases
Yana Igolkina, Aleksey Nikitin, Yulia Verzhutskaya, Natalia Gordeyko, Artem Tikunov, Tamara Epikhina, Nina Tikunova, Vera Rar
Summary: The discovery of Candidatus Rickettsia mendelii in 2016 in the Asian region has significant implications for the phylogeny of basal groups in Rickettsia spp.
TICKS AND TICK-BORNE DISEASES
(2023)
Article
Infectious Diseases
Dan Liu, Hongxia Fan, Xiaona Li, Fangchao Li, Ting Gao, Xuhong J. Yin, Zitong Zhang, Minzhi J. Cao, Hiroki Kawabata, Kozue J. Sato, Norio Ohashi, Shuji J. Ando, Gaowa
Summary: This study summarized the regional differences in tick infection and co-infection rates in Inner Mongolia, China. The results showed that pathogen diversity varied with ecogeographic differences and that ticks from the forest region had unexpectedly high infection and co-infection rates. The findings provide important information for clinicians in diagnosing tick-borne infectious diseases.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Infectious Diseases
Yana Igolkina, Vera Rar, Valeriy Yakimenko, Artem Tikunov, Nina Tikunova
Summary: A new candidate species of the spotted fever group, Candidatus Rickettsia thierseensis, was found in Austria and its gene sequences were highly similar to Candidatus Rickettsia uralica identified in Russia. Comparative sequence analysis confirmed that Candidatus R. uralica and Candidatus R. thierseensis are likely the same species.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Microbiology
Oxana A. Belova, Alexandra E. Polienko, Anastasia D. Averianova, Galina G. Karganova
Summary: The study analyzed the life cycle features of the hybrid between I. ricinus and I. persulcatus ticks under laboratory conditions. It was found that the hybrid generation is sterile, with decreased engorgement success in females and reduced hatched larvae. The morphogenetic diapause of the ticks also varied between the two species under laboratory conditions.
Article
Microbiology
Agne Namina, Alisa Kazarina, Marija Lazovska, Sarmite Akopjana, Viktorija Ulanova, Agnija Kivrane, Lauma Freimane, Darja Sadovska, Janis Kimsis, Antra Bormane, Valentina Capligina, Renate Ranka
Summary: This study compared the microbial composition of three tick species collected in Latvia using 16S rRNA profiling. The results showed significant differences in microbial diversity and composition among different tick species and life stages. The Francisella genus was closely associated with D. reticulatus ticks, while Candidatus Midichlorii and Candidatus Lariskella were associated with I. ricinus and I. persulcatus females, respectively.
Article
Infectious Diseases
Yana Igolkina, Vera Rar, Elena Krasnova, Eugenia Filimonova, Artem Tikunov, Tamara Epikhina, Nina Tikunova
Summary: This study aimed to determine the etiologic agents of tick-borne rickettsioses in Western Siberia during three epidemiological seasons. The findings showed that Rickettsia raoultii is a common agent of tick-borne rickettsioses in Novosibirsk Province, and DNA from Rickettsia aeschlimannii and Rickettsia slovaca was found in clinical samples of patients in the Russian Federation for the first time.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Immunology
Giovanni Sgroi, Roberta Iatta, Piero Lovreglio, Angela Stufano, Younes Laidoudi, Jairo Alfonso Mendoza-Roldan, Marcos Antonio Bezerra-Santos, Vincenzo Veneziano, Francesco Di Gennaro, Annalisa Saracino, Maria Chironna, Claudio Bandi, Domenico Otranto
Summary: During 2021, blood and serum samples were collected from 135 individuals exposed to tick bites in southern Italy. The study found a high circulation of tickborne pathogens and Candidatus M. mitochondrii DNA in the region, indicating the importance of coordinated surveillance for monitoring and controlling the spread of these pathogens.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Parasitology
Ekaterina K. Lagunova, Natalia A. Liapunova, Davaakhu Tuul, Gerechuluun Otgonsuren, Davaadorj Nomin, Nyamdorj Erdenebat, Davaajav Abmed, Galina A. Danchinova, Kozue Sato, Hiroki Kawabata, Maxim A. Khasnatinov
Summary: Ticks in Mongolia carry multiple tick-borne pathogens, including Borrelia spp. and relapsing fever agents. These pathogens persist independently in ticks, except for a possible shared circulation mode between A. phagocytophilum and Ehrlichia sp. Furthermore, the prevalence and spirochete load of Lyme disease and relapsing fever agents differ in ticks, suggesting different ecological niches.
PARASITES & VECTORS
(2022)
Article
Parasitology
Gaowa, Wulantuya, Kozue Sato, Dan Liu, Yunhong Cui, Xuhong Yin, Lihua Zhang, Hong Li, Tingfu Wang, Rongxin Liu, Lijing Wu, Saixia Lu, Ting Gao, Zitong Zhang, Minzhi Cao, Guodong Wang, Chunpu Li, Dacheng Yan, Norio Ohashi, Shuji Ando, Hiroki Kawabata
Summary: This study in Inner Mongolia, China, revealed a 5% prevalence of Borrelia miyamotoi in Ixodes persulcatus ticks. Additionally, it was found that 43.8% of the ticks carried Lyme disease borreliae. A strain of B. miyamotoi was successfully isolated, and its genome was identified as ST633, previously reported in Japan and Mongolia.
PARASITES & VECTORS
(2021)
Article
Microbiology
Lucyna Kirczuk, Mariusz Piotrowski, Anna Rymaszewska
Summary: Tick-borne pathogens monitoring is a significant issue in global medical and veterinary fields. This study used PCR technique to detect pathogens in Ixodes ricinus ticks in Northwest Poland, finding DNA of Rickettsia spp. and A. phagocytophilum, with R. helvetica as the only species of Rickettsia present.
Article
Infectious Diseases
Jani J. Sormunen, Veli-Matti Pakanen, Riikka Elo, Satu Makela, Jukka Hytonen
Summary: Despite extensive screening efforts on ticks in Finland, no ticks carrying Francisella tularensis were found, suggesting no circulation of the pathogen in local tick populations in the high-incidence region of tularaemia.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Microbiology
David T. Gauthier, Sandor E. Karpathy, Stephanie L. Grizzard, Dhwani Batra, Lori A. Rowe, Christopher D. Paddock
Summary: A previously unrecognized Rickettsia species, Rickettsia tillamookensis sp. nov., isolated from Ixodes pacificus ticks in Tillamook County, Oregon, USA, shows distinct characteristics from known species, with the closest similarity to Rickettsia asembonensis and Rickettsia felis. This potentially pathogenic species, identified through whole-genome sequencing, grows aerobically in various cell lines and is proposed as a new species based on accepted genomic criteria.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Article
Biology
Yuliya M. Didyk, Barbara Mangova, Eva Spitalska, Marketa Derdakova
Summary: Ticks in urban parks and green areas in Ukraine were found to carry Rickettsia spp. DNA, with 16.3% of I. ricinus and 29.1% of D. reticulatus testing positive. R. helvetica and R. monacensis were found in I. ricinus, while R. raoultii was found in D. reticulatus. This indicates a risk of rickettsiosis in popular tourist urban habitats in Ukraine.
Article
Microbiology
Neda Baseri, Mostafa Salehi-Vaziri, Ehsan Mostafavi, Fahimeh Bagheri Amiri, Mina Latifian, John Stenos, Saber Esmaeili
Summary: This study investigated the prevalence of Rickettsia conorii among suspected Crimean-Congo hemorrhagic fever patients in Iran. The results showed that Rickettsia conorii is indeed present in Iran and can be misdiagnosed with other febrile syndromes.
Article
Genetics & Heredity
Mikhail Yu Kartashov, Alexander N. Shvalov, Natalya L. Tupota, Vladimir N. Romanenko, Nina S. Moskvitina, Vladimir A. Ternovoi, Valery B. Loktev
MITOCHONDRIAL DNA PART B-RESOURCES
(2020)
Article
Oncology
Victor A. Svyatchenko, Sergey D. Nikonov, Alexander P. Mayorov, Mark L. Gelfond, Valery B. Loktev
Summary: PDT combined with MB and Radachlorin demonstrated high antiviral activity against SARS-CoV-2 in vitro, inactivating viral suspensions with TCID50 greater than 103 and protecting Vero E6 cells from infection.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Parasitology
Igor G. Korobitsyn, Nina S. Moskvitina, Oleg Yu. Tyutenkov, Sergey I. Gashkov, Yulia V. Kononova, Sergey S. Moskvitin, Vladimir N. Romanenko, Tamara P. Mikryukova, Elena V. Protopopova, Mikhail Yu. Kartashov, Eugene V. Chausov, Svetlana N. Konovalova, Natalia L. Tupota, Alexandra O. Sementsova, Vladimir A. Ternovoi, Valery B. Loktev
Summary: The study found that wild birds and ticks may play an important role in the dissemination of tick-borne pathogens, but pathogens in birds and ticks do not fully match in the majority of cases.
FOLIA PARASITOLOGICA
(2021)
Article
Biochemistry & Molecular Biology
Daniil Shanshin, Sophia S. Borisevich, Alexander A. Bondar, Yuri B. Porozov, Elena A. Rukhlova, Elena Protopopova, Nikita D. Ushkalenko, Valery B. Loktev, Andrei Chapoval, Alexander A. Ilyichev, Dmitriy N. Shcherbakov
Summary: Flaviviruses are RNA viruses that infect millions of people annually, causing severe diseases. There are no effective therapies against many flaviviruses. The use of neutralizing antibodies is a promising strategy for prevention and treatment of flavivirus infections. Our study identified the specific binding site of the 10H10 antibody on the E protein of flaviviruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Victor A. Svyatchenko, Vladimir A. Ternovoi, Roman Y. Lutkovskiy, Elena V. Protopopova, Andrei S. Gudymo, Nataliya V. Danilchenko, Ivan M. Susloparov, Nataliya P. Kolosova, Alexander B. Ryzhikov, Oleg S. Taranov, Vladimir V. Omigov, Elena V. Gavrilova, Alexander P. Agafonov, Rinat A. Maksyutov, Valery B. Loktev
Summary: In this study, the features of simultaneous and sequential co-infection with SARS-CoV-2 and human adenovirus type 5 (HAdV-5) or influenza A virus (IAV) were investigated in vitro and in vivo. It was found that HAdV-5 infection does not interfere with SARS-CoV-2 replication and co-infection with IAV results in more severe clinical manifestations and lung pathology. The expression of interferon and cytokine signaling pathway genes was also upregulated in co-infected animals compared to those infected with SARS-CoV-2 alone.
Article
Infectious Diseases
Kartashov M. Yu, E. I. Krivosheina, K. A. Svirin, N. L. Tupota, V. A. Ternovoi, V. B. Loktev
Summary: This study investigated the species composition and infection status of ticks in Novosibirsk and its suburbs. The results showed that the majority of ticks attacking humans were Ixodes persulcatus and Dermacentor reticulatus, and many of these ticks carried tick-borne encephalitis virus, Borrelia bacteria, and Rickettsia bacteria.
INFEKTSIYA I IMMUNITET
(2022)
Article
Infectious Diseases
Mikhail Y. Kartashov, Anastasia V. Gladysheva, Alexander N. Shvalov, Natalya L. Tupota, Anastasia A. Chernikova, Vladimir A. Ternovoi, Valery B. Loktev
Summary: A novel tick virus called HSTV was discovered in Asian Russia, which is genetically similar to unclassified Flavi-like viruses. It may belong to a new genus within Flaviviridae with enlarged viral genomes. Human incidents of HSTV infection were found in patients with tick-borne infections, causing fever and respiratory lesions after being bitten by Ixodes persulcatus ticks.
TICKS AND TICK-BORNE DISEASES
(2023)
Article
Virology
Vladimir A. Ternovoi, Alexander N. Shvalov, Mikhail Yu. Kartashov, Eugenia P. Ponomareva, Natalia L. Tupota, Yuri A. Khoroshavin, Roman B. Bayandin, Anastasia V. Gladysheva, Tamara P. Mikryukova, Tatyana V. Tregubchak, Valery B. Loktev, Jonas Schmidt-Chanasit, Hanna Joest
Summary: The metagenomic analysis of mosquitoes in Novosibirsk region of western Siberia revealed novel viral sequences that were classified into various orders and families. The study aimed to understand the viral diversity in mosquitoes in the natural habitats of Siberia.
Article
Biochemistry & Molecular Biology
E. P. Ponomareva, V. A. Ternovoi, T. P. Mikryukova, E. Protopopova, N. L. Tupota, V. B. Loktev
Summary: This study analyzed the nucleotide sequences of TBEV genomic RNA isolated from ticks collected in Northern Eurasia, revealing significant variability in the 5'-UTR among different TBEV genotypes. The identified nucleotide substitutions were typical for specific TBEV genotypes and located mainly in stem structures of the 5'-UTR. The findings suggest that genetic variability in the 5'-UTR may play a role in the efficient replication of TBEV in various host cells.
Article
Parasitology
Mikhail Yu Kartashov, Ekaterina Naidenova, Kirill S. Zakharov, Sergey A. Yakovlev, Maxim O. Skarnovich, Sanaba Boumbaly, Konstantin A. Nikiforov, Nikita A. Plekhanov, Andrey A. Kritzkiy, Vladimir A. Ternovoi, Mamadou Y. Boiro, Valery B. Loktev
Summary: This study detected Babesia and Theileria 18S ribosomal RNA genes in ticks collected from household cows in Guinea through PCR and sequencing, with an infection rate of 4.2%. The highest infection rate was found in Rh. annulatus ticks. Phylogenetic analysis revealed Babesia caballi, Theileria mutans and Theileria velifera as the genotypes present. These pathogens were discovered in all prefectures in Guinea except for Mamou Prefecture, suggesting the potential role of these ticks in transmitting piroplasm infections in domestic animals.
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS
(2021)
Review
Biochemistry & Molecular Biology
G. Kochneva, M. Yu Kartashov, E. Krivosheina, A. Kuznetsov, E. Chub, G. F. Sivolobova, S. Netesov
Summary: Long-term efforts of the international community have led to the development of highly efficient direct-acting antivirals (DAAs) for the treatment of chronic hepatitis C. These drugs target key proteins encoded by the hepatitis C virus genome, but the high mutation rate of HCV poses challenges in developing resistance to these drugs. Russia faces significant financial difficulties in achieving the WHO goal of eradicating HCV due to the high cost and large number of infected individuals.
MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY
(2021)
Article
Infectious Diseases
Harold Salant, Yaarit Nachum-Biala, Doni Zivotofsky, Tsachi Even Tzur, Gad Baneth
Summary: This study describes the presentation, clinical signs, parasitemia levels, laboratory findings and treatment of dogs infected with B. negevi. Treatment with imidocarb dipropionate was helpful for recovery from clinical disease but did not facilitate parasite elimination, and it is therefore recommended to treat canine B. negevi infection with the combination of atovaquone and azithromycin.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Gervillien Arnold Malonga, Almoustapha Issiaka Maiga, Dimitry Moudiongui Mboungou Malanda, Mahamadou Saliou, Juth ece Private Malanda-Kiminou, Oumar Dolo, Anicet Luc Magloire Boumba, Alhassane Ba, Robert Murphy, Jean Felix Peko, Anne-Genevieve Marcelin, Vincent Calvez, Stephane Marot
Summary: A serological survey in sub-urban areas of the capital cities of Congo and Mali reveals human contact with Crimean-Congo hemorrhagic fever virus (CCHFV) associated with previously described CCHFV risk factors.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Aleksander Wymazal, Sabina Nowak, Robert W. Myslajek, Anna Bajer, Renata Welc-Faleciak, Maciej Szewczyk, Iga Kwiatkowska, Kinga M. Stepniak, Michal Figura, Agnieszka Kloch
Summary: The wolf population in Central and Eastern Europe has been increasing, but their frequent contacts with humans make them a potential zoonotic reservoir. This study found a high prevalence of tick-borne pathogens in free-ranging wolves from Poland.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Nannet D. Fabri, Hans Heesterbeek, Joris P. G. M. Cromsigt, Frauke Ecke, Hein Sprong, Lonneke Nijhuis, Tim R. Hofmeester, Nienke Hartemink
Summary: In many parts of the northern hemisphere, different species of deer, small mammals, and birds coexist and their composition can strongly influence the outbreak potential of tick-borne pathogens. This study investigates how the abundance and composition of vertebrate communities affect the basic reproduction number R0 of tick-borne pathogens, and shows that species composition plays a substantial role in the outbreak potential of tick-borne diseases.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Lynn M. Osikowicz, Maria R. Rizzo, Andrias Hojgaard, Sarah E. Maes, Rebecca J. Eisen
Summary: This article describes the prevalence and diversity of Lyme disease in the United States. By using different detection methods, the authors found various species of spirochetes present in specific tick species, revealing the potential transmission of pathogens among ticks.
TICKS AND TICK-BORNE DISEASES
(2024)
Review
Infectious Diseases
El-Sayed El-Alfy, Ibrahim Abbas, Somaya Saleh, Rana Elseadawy, Ragab M. Fereig, Mohamed Abdo Rizk, Xuenan Xuan
Summary: Published data on tick-borne pathogens in camels worldwide have been collected, providing an overview of their global prevalence and species diversity. Evidence of natural infection of camels with certain tick-borne pathogens is limited, particularly because most of the camels were considered healthy at the time of sampling. More research is needed to understand the role of camels in maintaining and transmitting these pathogens.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Saana Sipari, Mikko Kiljunen, Minna Nylund, Eva R. Kallio
Summary: This study introduces a stable isotope analysis method to directly identify tick breeding hosts by sampling field collected larvae. The results show that stable isotope signatures can reflect the diet of the breeding host of the mother tick.
TICKS AND TICK-BORNE DISEASES
(2024)
