Type W Human Endogenous Retrovirus (HERV-W) Integrations and Their Mobilization by L1 Machinery: Contribution to the Human Transcriptome and Impact on the Host Physiopathology

Expression and regulation of human endogenous retrovirus W elements

(2016) Fang Li et al.   APMIS

Dynamic and selective HERV RNA expression in neuroblastoma cells subjected to variation in oxygen tension and demethylation

(2016) Lijuan Hu et al.   APMIS

The role of molecular mimicry and other factors in the association of Human Endogenous Retroviruses and autoimmunity

(2016) Malgorzata Trela et al.   APMIS

Human endogenous retroviruses in neurologic disease

(2016) Tove Christensen   APMIS

DNA methylation perspectives in the pathogenesis of autoimmune diseases

(2016) Bao Sun et al.   CLINICAL IMMUNOLOGY

MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment

(2016) Alexandra Madeira et al.   JOURNAL OF NEUROIMMUNOLOGY

Elevation of Ser9 phosphorylation of GSK3β is required for HERV-W env-mediated BDNF signaling in human U251 cells

(2016) Chengchen Qin et al.   NEUROSCIENCE LETTERS

Human endogenous retrovirus (HERV) expression is not induced by treatment with the histone deacetylase (HDAC) inhibitors in cellular models of HIV-1 latency

(2016) Tara Hurst et al.   Retrovirology

Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes

(2016) Nicole Grandi et al.   Retrovirology

Classification and characterization of human endogenous retroviruses; mosaic forms are common

(2016) Laura Vargiu et al.   Retrovirology

Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis

(2016) Jack van Horssen et al.   Multiple Sclerosis and Related Disorders

Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy

(2016) Raphaël Faucard et al.   EBioMedicine

Differential expression analysis of human endogenous retroviruses based on ENCODE RNA-seq data

(2015) Kerstin Haase et al.   BMC Medical Genomics

Morphological changes of placental syncytium and their implications for the pathogenesis of preeclampsia

(2015) Cynthia S. Roland et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CMV induces HERV-K and HERV-W expression in kidney transplant recipients

(2015) Massimiliano Bergallo et al.   JOURNAL OF CLINICAL VIROLOGY

Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements

(2015) David Díaz-Carballo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Activation of the innate immune response by endogenous retroviruses

(2015) T. P. Hurst et al.   JOURNAL OF GENERAL VIROLOGY

Epitopes of HERV-Wenv induce antigen-specific humoral immunity in multiple sclerosis patients

(2015) Giuseppe Mameli et al.   JOURNAL OF NEUROIMMUNOLOGY

Treatment Against Human Endogenous Retrovirus: A Possible Personalized Medicine Approach for Multiple Sclerosis

(2015) François Curtin et al.   Molecular Diagnosis & Therapy

Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection

(2015) Michelle Vincendeau et al.   Retrovirology

Transcriptional Activity of Human Endogenous Retroviruses in Human Peripheral Blood Mononuclear Cells

(2015) Emanuela Balestrieri et al.   Biomed Research International

Multiple Sclerosis between Genetics and Infections: Human Endogenous Retroviruses in Monocytes and Macrophages

(2015) Elena Morandi et al.   Frontiers in Immunology

HIV Tat acts on endogenous retroviruses of the W family and this occurs via Toll-like receptor 4

(2014) Elena Uleri et al.   AIDS

Human endogenous retrovirus expression is inversely related with the up-regulation of interferon-inducible genes in the skin of patients with lichen planus

(2014) Marcelle Almeida de Sousa Nogueira et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Reduced syncytin-1 expression in choriocarcinoma BeWo cells activates the calpain1–AIF-mediated apoptosis, implication for preeclampsia

(2014) Qiang Huang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Decreased Expression and Altered Methylation of Syncytin-1 Gene in Human Placentas Associated with Preeclampsia

(2014) Xue-Wei Zhuang et al.   CURRENT PHARMACEUTICAL DESIGN

Hypomethylation and Activation of Syncytin-1 Gene in Endometriotic Tissue

(2014) Hongyuan Zhou et al.   CURRENT PHARMACEUTICAL DESIGN

Transcriptional Derepression of the ERVWE1 Locus following Influenza A Virus Infection

(2014) F. Li et al.   JOURNAL OF VIROLOGY

Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein

(2014) François Curtin et al.   mAbs

The neutralizing antibody GNbAC1 abrogates HERV-W envelope protein-mediated oligodendroglial maturation blockade

(2014) David Kremer et al.   Multiple Sclerosis Journal

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV

(2014) Marta García-Montojo et al.   Retrovirology

Human Endogenous Retrovirus W Activity in Cartilage of Osteoarthritis Patients

(2014) Signy Bendiksen et al.   Biomed Research International

APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

(2014) Sandra R Richardson et al.   eLife

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia

(2013) Hedi Hegyi   Biology Direct

Syncytin-1 modulates placental trophoblast cell proliferation by promoting G1/S transition

(2013) Qiang Huang et al.   CELLULAR SIGNALLING

Role of Pathogens in Multiple Sclerosis

(2013) Jane E. Libbey et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Multiple sclerosis-associated retrovirus and related human endogenous retrovirus-W in patients with multiple sclerosis: A literature review

(2013) Gloudina M. Hon et al.   JOURNAL OF NEUROIMMUNOLOGY

Comprehensive Analysis of Human Endogenous Retrovirus Group HERV-W Locus Transcription in Multiple Sclerosis Brain Lesions by High-Throughput Amplicon Sequencing

(2013) K. Schmitt et al.   JOURNAL OF VIROLOGY

Human endogenous retrovirus W family envelope gene activates the small conductance Ca2+-activated K+ channel in human neuroblastoma cells through CREB

(2013) S. Li et al.   NEUROSCIENCE

Mutations in 3′-long terminal repeat of HERV-W family in chromosome 7 upregulate syncytin-1 expression in urothelial cell carcinoma of the bladder through interacting with c-Myb

(2013) H Yu et al.   ONCOGENE

'There and back again': revisiting the pathophysiological roles of human endogenous retroviruses in the post-genomic era

(2013) G. Magiorkinis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation

(2013) C. Lavialle et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The DNA Copy Number of Human Endogenous Retrovirus-W (MSRV-Type) Is Increased in Multiple Sclerosis Patients and Is Influenced by Gender and Disease Severity

(2013) Marta Garcia-Montojo et al.   PLoS One

Human Endogenous Retrovirus Protein Activates Innate Immunity and Promotes Experimental Allergic Encephalomyelitis in Mice

(2013) Hervé Perron et al.   PLoS One

Expression of Human Endogenous Retrovirus-W Including Syncytin-1 in Cutaneous T-Cell Lymphoma

(2013) Pilvi Maliniemi et al.   PLoS One

Human Cytomegalovirus (HCMV) induces Human Endogenous Retrovirus (HERV) transcription

(2013) Alice Assinger et al.   Retrovirology

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Human endogenous retroviruses and ADHD

(2013) Emanuela Balestrieri et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Genomic analysis of ERVWE2 locus in patients with multiple sclerosis: absence of genetic association but potential role of human endogenous retrovirus type W elements in molecular mimicry with myelin antigen

(2013) Guilherme S. do Olival et al.   Frontiers in Microbiology

Active human retrotransposons: variation and disease

(2012) Dustin C Hancks et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

(2012) Hervé Perron et al.   Multiple Sclerosis Journal

Syncytin 1 in the human placenta

(2012) B.S. Holder et al.   PLACENTA

The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes

(2012) J.M. Tolosa et al.   PLACENTA

Influence of Antipsychotic Drugs on Human Endogenous Retrovirus (HERV) Transcription in Brain Cells

(2012) Olivia Diem et al.   PLoS One

Microarray-Based Sketches of the HERV Transcriptome Landscape

(2012) Philippe Pérot et al.   PLoS One

Expression and Activation by Epstein Barr Virus of Human Endogenous Retroviruses-W in Blood Cells and Astrocytes: Inference for Multiple Sclerosis

(2012) Giuseppe Mameli et al.   PLoS One

HERVs Expression in Autism Spectrum Disorders

(2012) Emanuela Balestrieri et al.   PLoS One

Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder

(2012) H Perron et al.   Translational Psychiatry

LINE-1 Elements in Structural Variation and Disease

(2011) Christine R. Beck et al.   Annual Review of Genomics and Human Genetics

Human Endogenous Retroviruses in Multiple Sclerosis: Potential for Novel Neuro-Pharmacological Research

(2011) F. P. Ryan   Current Neuropharmacology

Expression of human endogenous retrovirus K is stimulated by ultraviolet radiation in melanoma

(2011) Oliver Schanab et al.   Pigment Cell & Melanoma Research

Age- and Disease-Dependent HERV-W Envelope Allelic Variation in Brain: Association with Neuroimmune Gene Expression

(2011) Rakesh K. Bhat et al.   PLoS One

Reduced Expression of Both Syncytin 1 and Syncytin 2 Correlates With Severity of Preeclampsia

(2011) Amandine Vargas et al.   Reproductive Sciences

Activation of LTRs from Different Human Endogenous Retrovirus (HERV) Families by the HTLV-1 Tax Protein and T-Cell Activators

(2011) Chirine Toufaily et al.   Viruses-Basel

Human endogenous retroviruses and multiple sclerosis: Innocent bystanders or disease determinants?

(2010) Joseph M. Antony et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Implication of Human Endogenous Retroviruses in the Development of Autoimmune Diseases

(2010) Eva Balada et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes

(2010) Matthias Ruebner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Custom human endogenous retroviruses dedicated microarray identifies self-induced HERV-W family elements reactivated in testicular cancer upon methylation control

(2010) Juliette Gimenez et al.   NUCLEIC ACIDS RESEARCH

An N-terminally truncated envelope protein encoded by a human endogenous retrovirus W locus on chromosome Xq22.3

(2010) Christina Roebke et al.   Retrovirology

Implication of the env Gene of the Human Endogenous Retrovirus W Family in the Expression of BDNF and DRD3 and Development of Recent-Onset Schizophrenia

(2010) W. Huang et al.   SCHIZOPHRENIA BULLETIN

Expression profiling of repetitive elements by melting temperature analysis: variation in HERV-W gag expression across human individuals and tissues

(2009) Christoffer Nellåker et al.   BMC GENOMICS

Classification and nomenclature of endogenous retroviral sequences (ERVs)

(2009) Jonas Blomberg et al.   GENE

Trisomy 21- affected placentas highlight prerequisite factors for human trophoblast fusion and differentiation

(2009) Andre Malassine et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The prevalence of human endogenous retroviruses in cerebrospinal fluids from patients with sporadic Creutzfeldt–Jakob disease

(2009) Byung-Hoon Jeong et al.   JOURNAL OF CLINICAL VIROLOGY

Effects of interferon-beta therapy on innate and adaptive immune responses to the human endogenous retroviruses HERV-H and HERV-W, cytokine production, and the lectin complement activation pathway in multiple sclerosis

(2009) Thor Petersen et al.   JOURNAL OF NEUROIMMUNOLOGY

Is the risk of multiple sclerosis related to the ‘biography’ of the immune system?

(2009) Bernd Krone et al.   JOURNAL OF NEUROLOGY

Endogenous retroviral genes, Herpesviruses and gender in Multiple Sclerosis

(2009) Hervé Perron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Novel reliable real-time PCR for differential detection of MSRVenv and syncytin-1 in RNA and DNA from patients with multiple sclerosis

(2009) Giuseppe Mameli et al.   JOURNAL OF VIROLOGICAL METHODS

Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis

(2009) M Saresella et al.   Multiple Sclerosis Journal

The impact of retrotransposons on human genome evolution

(2009) Richard Cordaux et al.   NATURE REVIEWS GENETICS

Analysis of transcribed human endogenous retrovirus W env loci clarifies the origin of multiple sclerosis-associated retrovirus env sequences

(2009) Georg Laufer et al.   Retrovirology

B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity

(2009) Tomasz Brudek et al.   Retrovirology

Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity

(2009) Eva Balada et al.   REVIEWS IN MEDICAL VIROLOGY

Effects of Retroviruses on Host Genome Function

(2008) Patric Jern et al.   Annual Review of Genetics

Quantitative expression of the HERV-W env gene in human tissues

(2008) H.-S. Kim et al.   ARCHIVES OF VIROLOGY

Endogenous Retrovirus Type W GAG and Envelope Protein Antigenemia in Serum of Schizophrenic Patients

(2008) Hervé Perron et al.   BIOLOGICAL PSYCHIATRY

Endogenous retroviruses

(2008) K. Ruprecht et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lack of immune responses against multiple sclerosis–associated retrovirus/human endogenous retrovirus W in patients with multiple sclerosis

(2008) Klemens Ruprecht et al.   JOURNAL OF NEUROVIROLOGY

Inhibition of multiple sclerosis–associated retrovirus as biomarker of interferon therapy

(2008) Giuseppe Mameli et al.   JOURNAL OF NEUROVIROLOGY

The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease

(2008) Antonina Dolei et al.   JOURNAL OF NEUROVIROLOGY

Human RNA "Rumor" Viruses: the Search for Novel Human Retroviruses in Chronic Disease

(2008) C. Voisset et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS