Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

The role of icaritin in regulating Foxp3/IL17a balance in systemic lupus erythematosus and its effects on the treatment of MRL/lpr mice

(2016) Jieyue Liao et al.   CLINICAL IMMUNOLOGY

Involvement of IGF-1 receptor signaling pathway in the neuroprotective effects of Icaritin against MPP + -induced toxicity in MES23.5 cells

(2016) Ming-Chun Jiang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?

(2016) Johanna Troberg et al.   MOLECULAR PHARMACEUTICS

A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variants

(2015) Feng Sun et al.   CARCINOGENESIS

Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling

(2015) Hua Sun et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Systematic considerations for a multicomponent pharmacokinetic study of Epimedii wushanensis herba: From method establishment to pharmacokinetic marker selection

(2015) Caihong Wang et al.   PHYTOMEDICINE

Metabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1

(2015) Danyi Lu et al.   XENOBIOTICA

Glucuronidation of macelignan by human liver microsomes and expressed UGT enzymes: identification of UGT1A1 and 2B7 as the main contributing enzymes

(2014) Hongming Liu et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Identification of Metabolites of Epimedin A in Rats Using UPLC/Q–TOF–MS

(2014) Li Cui et al.   CHROMATOGRAPHIA

Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences

(2014) Hua Sun et al.   Expert Opinion on Drug Metabolism & Toxicology

PLGA/TCP composite scaffold incorporating bioactive phytomolecule icaritin for enhancement of bone defect repair in rabbits

(2013) S.-H. Chen et al.   Acta Biomaterialia

A new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometry

(2013) Ying Jin et al.   ANALYTICA CHIMICA ACTA

The beneficial effect of Icaritin on osteoporotic bone is dependent on the treatment initiation timing in adult ovariectomized rats

(2013) Songlin Peng et al.   BONE

Quantitative Prediction of Glucuronidation in Humans Using the In Vitro- In Vivo Extrapolation Approach

(2013) Baojian Wu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-quadrupole/time-of-flight mass spectrometry

(2012) Qian Qian et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Oral absorption and excretion of icaritin, an aglycone and also active metabolite of prenylflavonoids from the Chinese medicine Herba Epimedii in rats

(2012) Qi Chang et al.   PHYTOMEDICINE

Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats

(2011) Jing Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

The genus Epimedium: An ethnopharmacological and phytochemical review

(2011) Huiping Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics

(2011) Baojian Wu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Liquid chromatography–tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums

(2010) Haiyu Zhao et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

(2008) S. Ohno et al.   DRUG METABOLISM AND DISPOSITION

Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines

(2008) A. Nakamura et al.   DRUG METABOLISM AND DISPOSITION

Intestinal Absorption Mechanisms of Prenylated Flavonoids Present in the Heat-Processed Epimedium koreanum Nakai (Yin Yanghuo)

(2008) Yan Chen et al.   PHARMACEUTICAL RESEARCH