Review
Clinical Neurology
Seetal Dodd, Luba Sominsky, Dan Siskind, Chiara C. Bortolasci, Andre F. Carvalho, Michael Maes, Adam J. Walker, Ken Walder, Alison R. Yung, Lana J. Williams, Hannah Myles, Tayler Watson, Michael Berk
Summary: Advances in psychopharmacology have been slower compared to other medical disciplines, leading to a need for investigation into novel therapeutic approaches. Metformin, a widely used hypoglycaemic agent, is being studied for potential repurposing in the treatment of mental illness, showing beneficial effects on various neurobiological pathways.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Clinical Neurology
Seetal Dodd, Luba Sominsky, Dan Siskind, Chiara C. Bortolasci, Andre F. Carvalho, Michael Maes, Adam J. Walker, Ken Walder, Alison R. Yung, Lana J. Williams, Hannah Myles, Tayler Watson, Michael Berk
Summary: Advances in psychopharmacology have been slow, necessitating investigation into new therapeutic approaches. Metformin, a widely used hypoglycemic agent, is being studied for its potential use in mental illness treatment beyond diabetes management.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Multidisciplinary
Rebecka Ekelund, Stefan Holmstrom, Andreas Stenling
Summary: There is a lack of empirical evidence on the effectiveness of psychotherapeutic interventions for mental health problems and disorders in athletes, and the definitions and assessments of these issues vary, leading to limited understanding of the extent of mental health problems and disorders in athletes. Further research is needed to include athletes with established mental health problems and disorders in intervention studies, and the use of N-of-1 trials should be increased to enhance knowledge in this area.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Health Care Sciences & Services
Claudia Pisanu, Erika Vitali, Anna Meloni, Donatella Congiu, Giovanni Severino, Raffaella Ardau, Caterina Chillotti, Luigi Trabucchi, Marco Bortolomasi, Massimo Gennarelli, Alessandra Minelli, Alessio Squassina
Summary: Psychiatric disorders may exhibit premature cell senescence, but the relationship between leukocyte telomere length (LTL) and response to electroconvulsive therapy (ECT) is inconclusive. LTL was found to be shorter in patients with treatment-resistant major depressive disorder (MDD) and bipolar disorder (BD) compared to controls, but baseline LTL was not predictive of ECT response. No significant overlap between genetic variants associated with LTL and ECT response was observed.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Irene H. H. de Vlaming, Melanie P. J. Schellekens, Marije L. L. van der Lee
Summary: This study aimed to investigate whether Early Maladaptive Schemas (EMSs) predict the intensity of mental health treatment for cancer-related psychopathology. The findings revealed that more severe EMSs predicted a higher intensity of mental health treatment. Therefore, assessing EMSs can help identify patients in need of more treatment time.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Pathology
Muath Suliman, Sulieman Ibraheem Shelash Al-Hawary, F. Al-dolaimy, Ahmed Hjazi, Sami G. Almalki, Adnan Taan Alkhafaji, Ahmed Hussien Alawadi, Ali Alsaalamy, Sheela Bijlwan, Yasser Fakri Mustafa
Summary: Stem cell therapy is a promising treatment for inflammatory diseases and brain diseases, but it requires thorough evaluation and overcoming challenges before clinical applications.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Swati Sagarika Panda, Akankshya Nayak, Srishti Shah, Palok Aich
Summary: Obesity is a complex health condition that increases the risk of cardiovascular diseases, diabetes, and metabolic health issues. It also has a significant impact on the patient's mental state, leading to various mental disorders. The gut microbiota plays a vital role in regulating host physiology, and understanding its role in the interaction between obesity and mental disorders is important.
Review
Neurosciences
Xiao-yue Shen, Shu-han Shi, Heng Li, Cong-cong Wang, Yao Zhang, Hui Yu, Yan-bin Li, Bin Liu
Summary: This study provides an overview of the preclinical and clinical effects of Gadd45b, as well as its hypothesized mechanisms of action, in various neurological diseases.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Soile Tuovinen, Marius Lahti-Pulkkinen, Polina Girchenko, Kati Heinonen, Jari Lahti, Rebecca M. Reynolds, Esa Hamalainen, Pia M. Villa, Eero Kajantie, Hannele Laivuori, Katri Raikkonen
Summary: Maternal antenatal stress, including symptoms of depression, anxiety, and perceived stress, is associated with a higher risk of childhood mental and behavioral disorders. Especially when mothers report consistently high levels of all types of stress throughout pregnancy.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biology
Stefania Lamponi
Summary: Natural anticoagulant drugs can be obtained from plants, which have antioxidant, anticoagulant, and antiplatelet properties for treating thrombotic diseases. Studies have shown that many plants contain bioactive compounds with antiplatelet and anticoagulant activity, making them potential candidates for interfering with hemostasis.
Article
Multidisciplinary Sciences
Abdulnaser A. Fakhrou, Taha R. Adawi, Sara A. Ghareeb, Atef M. Elsherbiny, Maryam M. Alfalasi
Summary: Mental disorders significantly impact children's lives and their emotional, cognitive, and behavioral development. Family support is crucial for the well-being of children, especially those with mental disorders. However, there is a research-practice gap in the Arab region, and few studies have focused on the role of the family in supporting children with mental disorders.
Article
Public, Environmental & Occupational Health
Sheikh Mohammed Shariful Islam, Mohammed Islam
Summary: A comprehensive analysis of the Global Burden of Disease Study (GBD) 2019 revealed the disease burden and trends in Australia from 1990 to 2019. Non-communicable diseases remained the leading cause of mortality in Australia, with low back pain, depressive disorders, and other musculoskeletal diseases being the main contributors to disability-adjusted life-years (DALYs). High BMI, smoking, high blood pressure, high fasting plasma glucose, and drug use were identified as the leading risk factors for DALYs. Australia's ranking improved for death rates and life expectancy, but not for years lived with disability (YLDs) and years of life lost (YLLs) compared to similar countries.
LANCET PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Christina Driver, Timothy N. W. Jackson, Jim Lagopoulos, Daniel F. Hermens
Summary: The psychedelic renaissance has sparked interest in drugs such as N-methyl-D-aspartate receptor (NMDAR) antagonists, which have potential therapeutic effects in the treatment of mental health disorders. These drugs modulate excitatory signaling in the central nervous system and have potential for treating various neurological disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Emma L. Connolly, Marc Sim, Nikolaj Travica, Wolfgang Marx, Gemma Beasy, Gordon S. Lynch, Catherine P. Bondonno, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst
Summary: Research suggests that a diet rich in fruits and vegetables can delay and prevent the onset of chronic diseases, particularly certain cancers. Glucosinolates in cruciferous vegetables have anti-inflammatory, antioxidant, and chemo-protective effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Lukas Sveikata, Andreas Charidimou, Anand Viswanathan
Summary: This article reviews the implications of aducanumab amyloid-beta immunotherapy for treating Alzheimer's disease with comorbid cerebral amyloid angiopathy. It discusses the potential impact of cerebral amyloid angiopathy on the effectiveness of immunotherapy and proposes strategies to identify it in patients considered for this treatment.
Article
Health Care Sciences & Services
Liv Betker, Katharina Nagelschmidt, Nico Leppin, Jorge Riera Knorrenschild, Christian Volberg, Daniel Berthold, Ulf Sibelius, Winfried Rief, Antonia Barke, Pia von Blanckenburg, Carola Seifart
Summary: The study demonstrates that DEOLD-FI is an effective and reliable tool for assessing difficulties in end-of-life discussions. Results show that individuals who have engaged in end-of-life discussions have fewer communication barriers.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Review
Psychiatry
Lena Sarter, Jens Heider, Lukas Kirchner, Sandra Schenkel, Michael Witthoeft, Winfried Rief, Maria Kleinstauber
Summary: Cognitive behavior therapy is effective for treating patients with medically unexplained symptoms, but those with comorbid mood disorders, anxiety disorders, symptom catastrophizing, somatosensory amplification tendencies, and low self-efficacy have a less favorable outcome. These associations are more pronounced in patients with chronic fatigue syndrome and irritable bowel syndrome.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Neurosciences
Cornelia Exner, Bettina K. Doering, Nico Conrad, Anna Kuenemund, Sarah Zwick, Kerstin Kuehl, Steffen Nestler, Winfried Rief
Summary: The study found that an integrated intervention of neuropsychological and cognitive behavioral therapy can significantly improve general psychopathology, negative affect, and quality of life in outpatients with ABI, with positive effects maintained during follow-up.
NEUROPSYCHOLOGICAL REHABILITATION
(2022)
Article
Psychiatry
Laura M. -L. Dorn, Nele Struck, Florian Bitsch, Irina Falkenberg, Tilo Kircher, Winfried Rief, Stephanie Mehl
Summary: Patients with psychosis showed more pronounced deficits in Cognitive and Affective ToM compared to non-clinical controls, while there were no significant differences in Hyper-ToM errors. Deficits in Cognitive ToM were associated with general delusions, while problems in Affective ToM were linked to negative and disorganized symptoms. Furthermore, there was no association between Hyper-ToM errors and any symptoms when controlling for educational level.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Philipp Herzog, Bernhard Osen, Christian Stierle, Thomas Middendorf, Ulrich Voderholzer, Stefan Koch, Matthias Feldmann, Winfried Rief, Eva-Lotta Brakemeier
Summary: This study investigated the naturalistic effectiveness of routine inpatient treatment for patients with OCD and identified predictors of treatment outcome. Results indicate that, in addition to established predictors, social support and washing compulsions were identified as important positive predictors. Specific predictor profiles for changes in obsessions and compulsions were discussed.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Julia W. Haas, Winfried Rief, Frauke Weiss, Bettina K. Doering, Maria Kleinstaeuber, Sina Ruwoldt, Lena Sarter, Ruth Thomas, Julia Rheker
Summary: A doctor's patient-centered communication style positively influences participants' intention to take medication, but does not directly affect their behavioral outcomes. Future studies should further explore the role of communication in populations taking medication long-term.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Article
Anesthesiology
Beatrice Korwisi, Antonia Barke, Winfried Rief, Rolf-Detlef Treede, Maria Kleinstaeuber
Summary: For the first time, the upcoming ICD-11 will include a comprehensive classification of chronic pain, based on the biopsychosocial definition. This publication provides answers to frequently asked questions about the ICD-11 chronic pain classification, aiming to guide future users and facilitate its implementation.
Article
Psychology, Clinical
Julia Haneveld, Rita Rosner, Anna Vogel, Anette Kersting, Winfried Rief, Regina Steil, Hannah Comtesse
Summary: This study investigated the concordance between the diagnostic criteria for prolonged grief disorder (PGD) in DSM-5-TR and ICD-11. The results showed significant differences in diagnostic rates, mainly due to the time criterion and the presentation of core symptoms. With the potential increase in PGD prevalence rates during the COVID-19 pandemic, practitioners should be cautious about the diagnostic rule used and consider a stepped-care approach if there is uncertainty about the presence of full-blown PGD.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Marie Neubert, Philipp Suessenbach, Winfried Rief, Frank Euteneuer
Summary: Previous research on the relationship between social status and pain has produced inconsistent findings. This study aimed to explore the causal relationship between perceived social status and pain thresholds through experimental manipulation. Fifty-one female undergraduates were assigned to either a low or high-status condition. Participants' pain thresholds were measured before and after manipulating their perception of social status. The results showed that participants in the low-status condition reported increased pain thresholds after the manipulation, while those in the high-status condition reported decreased pain thresholds (beta = 0.22; 95% CI, 0.002 to 0.432; p < .05). These findings suggest that perceived social status may have a causal effect on pain thresholds.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Article
Anesthesiology
Jenny Riecke, Winfried Rief, Gunnar Lemmer, Julia A. Glombiewski
Summary: This study aimed to investigate the long-term treatment effects of cognitive behavioural therapy (CBT) and exposure therapy on chronic pain patients. The results showed that both psychological treatments were effective in maintaining treatment effects over several years, providing a sustainable long-term treatment option for chronic back pain patients.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Psychology, Clinical
Anna Seewald, Winfried Rief
Summary: This study investigates the impact of therapist's interpersonal behavior on alliance, motivation, outcome expectations (OE), and health behavior. The results suggest that the therapist's warmth and competence have a positive effect on alliance, motivation, and OE. However, there was no effect on health behavior.
PSYCHOTHERAPY RESEARCH
(2023)
Article
Psychology, Clinical
Julia Haneveld, Rita Rosner, Anna Vogel, Svenja Makitalo, Julia Treml, Regina Steil, Winfried Rief, Hannah Comtesse
Summary: This study developed a therapeutic adherence and competence scale for grief-focused CBT (TACs-G) and conducted a psychometric evaluation. The results showed high inter-rater reliability and strong stability over time for the TACs-G, indicating its reliability as a tool for internal validity and psychotherapy process research.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Article
Psychology, Clinical
Katharina Senger, Annette Schroeder, Maria Kleinstaeuber, Julian A. Rubel, Winfried Rief, Jens Heider
Summary: This study aimed to identify predictors of therapy outcomes for patients with somatic symptom disorder and used the Personalized Advantage Index (PAI) to calculate individualized optimal treatments. Analysis revealed both treatment unspecific predictors and treatment specific moderators, which significantly improved outcomes for personalized treatments compared to randomized conditions.
PSYCHOTHERAPY RESEARCH
(2022)
Article
Psychology, Clinical
Anke Haberkamp, Hannah Walter, Phillipp Althaus, Matthias Schmuck, Winfried Rief, Filipp Schmidt
Summary: By combining exposure principles with gamification elements, mobile applications can effectively reduce arachnophobia symptoms. Participants in the experimental group showed improvements in avoidance behavior and spider anxiety after a week of training, while the control group showed no significant changes.
JOURNAL OF ANXIETY DISORDERS
(2021)
Article
Psychology, Clinical
Katharina Nagelschmidt, Nico Leppin, Carola Seifart, Winfried Rief, Pia von Blanckenburg
Summary: Early conversations about the end of life are important for patient-centered care. This qualitative research identified prerequisites, difficulties, and usefulness of such conversations for healthy older adults. The findings can help in developing interventions to increase readiness for end-of-life discussions.
PSYCHOTHERAPIE PSYCHOSOMATIK MEDIZINISCHE PSYCHOLOGIE
(2021)
