期刊
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
卷 33, 期 5, 页码 -出版社
SPRINGER
DOI: 10.1007/s11274-017-2257-y
关键词
Lipid biosynthesis; Unsaturated fatty acids; Membranes; Evolution
资金
- Sapienza Universita di Roma [C26A147BSJ]
- Ministero Affari Esteri e Cooperazione Internazionale, Direzione generale per la Promozione del Sistema Paese [MX14MO08, PGR00208, PGR00209]
Fatty acid composition of biological membranes functionally adapts to environmental conditions by changing its composition through the activity of lipid biosynthetic enzymes, including the fatty acid desaturases. Three major desaturases are present in yeasts, responsible for the generation of double bonds in position C9-C10, C12-C13 and C15-C16 of the carbon backbone. In this review, we will report data addressed to define the functional role of basidiomycete and ascomycete yeast desaturase enzymes in response to various external signals and the regulation of the expression of their corresponding genes. Many yeast species have the complete set of three desaturases; however, only the Delta 9 desaturase seems to be necessary and sufficient to ensure yeast viability. The evolutionary issue of this observation will be discussed.
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