Article
Oncology
Alexandra M. Zaborowski
Summary: This study evaluated the characteristics and outcomes of patients with early-onset colorectal cancer (CRC). It found that most patients were symptomatic at diagnosis, with tumors primarily located in the descending colon. A high proportion had lymph node involvement and microsatellite instability. The survival rate for patients under 50 years old was generally lower.
Article
Gastroenterology & Hepatology
Pooja Dharwadkar, Garrett Greenan, Elena M. Stoffel, Ezra Burstein, Sara Pirzadeh-Miller, Sayoni Lahiri, Caitlin Mauer, Amit G. Singal, Caitlin C. Murphy
Summary: Racial/ethnic differences exist in referral to and receipt of germline genetic testing among young-onset CRC patients. These findings underscore the importance of universal genetic testing to address racial/ethnic disparities in young-onset CRC.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Oncology
Joy Zhou Done, Sandy H. Fang
Summary: Despite the overall decline in colorectal cancer incidence since the early 1990s, the incidence in patients under 50 years old has almost doubled. A systematic review on young-onset colorectal cancer highlighted an increasing incidence and emphasized the importance of considering colorectal cancer in the differential diagnosis of gastrointestinal symptoms in young adults.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Joshua Franklyn, Joe Lomax, Peter L. Z. Labib, Amy Baker, Supriya Balasubramanya, Joe Natale, Muhammad Abdalkoddus, Joanne Hosking, Mark G. Coleman, Sebastian Smolarek
Summary: This study analyzed the demographics, clinicopathological features, and prognosis of young colorectal cancer (CRC) patients in England. The results showed that young patients had a higher prevalence of right-sided colon cancer and better overall and relative survival rates compared to older patients with CRC.
COLORECTAL DISEASE
(2022)
Article
Oncology
Elio Adib, Talal El Zarif, Amin H. Nassar, Elie W. Akl, Sarah Abou Alaiwi, Tarek H. Mouhieddine, Edward D. Esplin, Kathryn Hatchell, Sarah M. Nielsen, Huma Q. Rana, Toni K. Choueiri, David J. Kwiatkowski, Guru Sonpavde
Summary: This study mapped the landscape of P/LP germline variants in the CDH1 gene across various cancers and ethnicities. The results showed significant enrichment of CDH1 P/LP variants in patients with CSRCC, DGC, and LBC across different ethnicities. Future prospective studies are needed to further validate these findings.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Lulu Tan, Xiakeerzhati Xiaohalati, Feng Liu, Jia Liu, Haoyu Fu, Yang Zhang, Jinbo Gao, Kaixiong Tao, Guobin Wang, Lin Wang, Zheng Wang
Summary: In order to explore the effects of aging on colorectal cancer (CRC) progression and treatment outcomes, this study established aging subtypes using 28 aging-related genes. The aging subtype of CRC showed distinct molecular features, higher frequencies of TP53 and immune checkpoint molecules, and high sensitivity to certain inhibitors. A risk signature based on 14 aging-related genes was also constructed, which exhibited good prediction and discrimination power. These findings provide new opportunities for personalized treatment and prognosis evaluation of CRC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hui Yao, Chengjie Li, Xiaodong Tan
Summary: The study identified 279 age-related DEGs from the TCGA database, with GO and KEGG analysis showing enrichment in the modulation of chemical synaptic transmission and neuroactive ligand-receptor interaction. Functional pathways related to the prognostic gene signature were explored by GSEA, and a key module associated with these genes was identified using WGCNA.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Manon C. W. Spaander, Ann G. Zauber, Sapna Syngal, Martin J. Blaser, Joseph J. Sung, Y. Nancy You, Ernst J. Kuipers
Summary: In the past decades, the incidence of early-onset colorectal cancer (CRC) or young-onset CRC (YO-CRC) has increased globally in both men and women. About 20% of YO-CRC patients have a hereditary cancer syndrome, while most cases have no genetic predisposition. Lifestyle changes such as antibiotic use, low physical activity, and obesity since the 1950s have been suggested as important factors in YO-CRC development by affecting the gut microbiome. Long-term prospective studies with childhood lifestyle data are needed to better understand the underlying mechanisms and relationships between environmental factors and YO-CRC.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Editorial Material
Gastroenterology & Hepatology
Giandomenico Roviello, Daniele Lavacchi, Lorenzo Antonuzzo, Martina Catalano, Enrico Mini
Summary: Liquid biopsy is a promising tool in the clinical management of colorectal cancer, with the potential for diagnosis, prognosis, monitoring, and treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Hafdis T. Helgadottir, Jessada Thutkawkorapin, Anna Rohlin, Margareta Nordling, Kristina Lagerstedt-Robinson, Annika Lindblom
Summary: Identifying pathogenic variants remains challenging despite a strong history of CRC within families. Some rare high-risk mutations may cumulatively contribute to the occurrence of CRC in these families.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Lucas Buk Cardoso, Vanderlei Cunha Parro, Stela Verzinhasse Peres, Maria Paula Curado, Gisele Aparecida Fernandes, Victor Wuensch Filho, Tatiana Natasha Toporcov
Summary: Colorectal cancer is a prevalent cancer worldwide, with about 2 million new cases annually. Machine learning algorithms have been increasingly used in cancer studies, providing important information and predictions based on data. This study used patient data from São Paulo, Brazil and five different classification algorithms to predict survival in colorectal cancer patients, achieving an accuracy of approximately 77% with an AUC of 0.86, with clinical staging being the most important feature.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Xiaofei Cheng, Yanqing Li, Dong Chen, Xiangming Xu, Fanlong Liu, Feng Zhao
Summary: In this study, we developed a unique nomogram incorporating clinical and pathological characteristics to predict the survival of young-onset patients with CRLM. The nomogram showed high accuracy and sensitivity, and was superior to the traditional TNM staging system in predicting survival.
Review
Biochemistry & Molecular Biology
Alvaro Gutierrez, Hannah Demond, Priscilla Brebi, Carmen Gloria Ili
Summary: Colorectal cancer is the third most common cancer globally, and biomarkers play a crucial role in diagnosis and predicting metastasis. Key signaling pathways associated with cancer progression include the MAPK pathway, p53 pathway, and TGF-beta pathway.
Review
Biochemistry & Molecular Biology
Liuxiang Chen, Liansong Ye, Bing Hu
Summary: This article discusses the molecular basis and prevention strategies for hereditary colorectal cancer syndromes, including familial adenomatous polyposis (FAP) and Lynch syndrome (LS). The development of molecular genetics has enhanced the study of cancer predisposing genes, which can help identify and guide the prevention and treatment of CRC.
Article
Surgery
Maria Daca-Alvarez, Marc Marti, Antonino Spinelli, Noel F. F. C. de Miranda, Claire Palles, Alfredo Vivas, Andrew Lachtford, Kevin Monahan, Marek Szczepkowski, Wieslaw Tarnowski, Silviu-Tiberiu Makkai-Popa, Rosario Vidal, Irene Lopez, Elena Hurtado, Fernando Jimenez, Marta Jimenez-Toscano, Edurne Alvaro, Gonzalo Sanz, Araceli Ballestero, Sirio Melone, Lorena Brandariz, Isabel Prieto, Damian Garcia-Olmo, Teresa Ocana, Rebeca Moreira, Lorena Moreno, Sabela Carballal, Leticia Moreira, Maria Pellise, Rogelio Gonzalez-Sarmiento, Andreana N. Holowatyj, Jose Perea, Francesc Balaguer
Summary: This study aimed to explore the impact of family history on preventing early-onset colorectal cancer, finding that the proportion of preventable cases varied based on different guidelines. Early colonoscopy could significantly decrease the incidence of familial early-onset colorectal cancer.
BRITISH JOURNAL OF SURGERY
(2022)