Article
Medicine, General & Internal
Erica K. Barnell, Elizabeth M. Wurtzler, Julie La Rocca, Thomas Fitzgerald, Jessica Petrone, Yansheng Hao, Yiming Kang, Faith L. Holmes, David A. Lieberman
Summary: This study evaluated the sensitivity and specificity of a noninvasive multitarget stool RNA test for colorectal cancer and precancerous lesions. The results showed that the test had a sensitivity of 94% for detecting colorectal cancer and 46% for detecting advanced adenomas, with a specificity of 88%.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Elizabeth Herring, Eric Tremblay, Nathalie McFadden, Shigeru Kanaoka, Jean-Francois Beaulieu
Summary: Colorectal cancer remains one of the deadliest cancers, with early detection being crucial for reducing mortality. Using targeted mRNA assay in stools can optimize the identification of precancerous lesions and curable colorectal cancers. Host mRNA stool testing shows potential in improving colorectal cancer screening efficacy.
Article
Medicine, General & Internal
Willemijn de Klaver, Pieter H. A. Wisse, Francine van Wifferen, Linda J. W. Bosch, Connie R. Jimenez, Rene W. M. van der Hulst, Remond J. A. Fijneman, Ernst J. Kuipers, Marjolein J. E. Greuter, Beatriz Carvalho, Manon C. W. Spaander, Evelien Dekker, Veerle M. H. Coupe, Meike de Wit, Gerrit A. Meijer
Summary: In this study, the multitarget FIT (mtFIT) showed improved diagnostic accuracy in detecting advanced neoplasia compared to FIT, particularly in detecting advanced adenomas. Early health technology assessment indicated that mtFIT-based screening could be cost-effective.
ANNALS OF INTERNAL MEDICINE
(2021)
Review
Surgery
Thomas K. Kleinschmidt, Austin Clements, Mark A. Parker, Steven D. Scarcliff
Summary: Noninvasive multitarget stool DNA testing is not an effective screening test for colorectal cancer due to its low positive predictive value. However, its noninvasive nature has been found to increase colorectal cancer screening rates in non-compliant Medicare patients.
Article
Gastroenterology & Hepatology
Junfeng Xu, Long Rong, Fang Gu, Peng You, Hui Ding, Huihong Zhai, Bangmao Wang, Yanqing Li, Xianzong Ma, Fumei Yin, Lang Yang, Yuqi He, Jianqiu Sheng, Peng Jin
Summary: This study evaluated the performance of the Asia-Pacific Colorectal Screening (APCS) scoring system combined with stool DNA test in colorectal cancer screening. The results showed that this combination significantly improved the detection of early colorectal neoplasms and reduced the workload of colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Yingshuang Zhu, Yanqin Huang, Yeting Hu, Yimin Fang, Xiangxing Kong, Qian Xiao, Jinjie He, Yunfeng Zhu, Qilong Li, Jinhuan Yang, Qi Dong, Mingjuan Jin, Meilin Wang, Kun Chen, Shu Zheng, Kefeng Ding
Summary: This study found that individuals with high-risk adenomas (at least one advanced adenoma or >= 3 nonadvanced adenomas) have an increased risk of subsequent CRC in the Chinese population, while those with 1 to 2 nonadvanced adenomas do not show significantly increased risk of CRC. These results provide valuable evidence for the current surveillance guidelines in China.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Diana G. Redwood, Tuan A. Dinh, John B. Kisiel, Bijan J. Borah, James P. Moriarty, Ellen M. Provost, Frank D. Sacco, James J. Tiesinga, David A. Ahlquist
Summary: The study aimed to evaluate the cost-effectiveness of multitarget stool DNA testing (MT-sDNA) compared with colonoscopy and fecal immunochemical testing (FIT) for Alaska Native adults. Results showed that MT-sDNA demonstrated significant cost-effectiveness in different adherence scenarios, with clear advantages in terms of QALYs savings.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Gastroenterology & Hepatology
Erica K. Barnell, Yiming Kang, Andrew R. Barnell, Kimberly R. Kruse, Jared Fiske, Zachary R. Pittz, Adnan R. Khan, Thomas A. Huebner, Faith L. Holmes, Malachi Griffith, Obi L. Griffith, Aadel A. Chaudhuri, Elizabeth M. Wurtzler
Summary: The RNA-FIT test showed high sensitivity for detecting CRC and AAs, as well as specificity for hyperplastic polyps and no findings on colonoscopy. This assay could be a promising noninvasive option for screening both CRC and precancerous adenomas.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Editorial Material
Oncology
David Lieberman
Summary: There is solid evidence supporting the effectiveness of colorectal cancer screening in reducing incidence and mortality. Guidelines suggest screening for individuals between 45 to 75 years old, but there is uncertainty regarding the benefits for those above 75 years old. Dalmat et al. found that individuals who had a negative colonoscopy more than 10 years prior to reaching 76 to 85 years old had a lower risk of colorectal cancer and may not benefit from further screening. It is important to consider the study population did not include individuals with a family history of colon cancer or high-risk adenomas.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Review
Oncology
Edward Young, Louisa Edwards, Rajvinder Singh
Summary: Artificial intelligence (AI) systems have become increasingly available in the field of endoscopy, particularly in colonoscopy. This comprehensive review focuses on the application of AI in detecting and characterizing colorectal polyps, with the goal of improving the efficacy of colorectal cancer screening and prevention. AI-driven algorithms show potential in addressing the challenge of overlooked polyps and empowering gastroenterologists to accurately characterize polyps without extensive training in advanced mucosal imaging. By integrating AI technologies into routine colonoscopy, the detection and characterization of polyps can be advanced, potentially leading to more effective colorectal cancer screening and prevention.
Article
Health Care Sciences & Services
Yuan Ze, Huiming Tu, Lin Zhang, Yu Bai, Yilin Ren, Xin Chen, Yuzheng Xue, Renjuan Sun, Yuling Yang, Jie Yang, Xuan Zhou, Li Liu
Summary: This study compared the screening efficacy of colonoscopy and various Asia-Pacific colorectal screening protocols. The results showed that both FIT and sDNA testing had 100% performance in detecting colorectal cancer. The FIT + sDNA test scheme had a sensitivity of 29.2% for advanced adenoma, while the combined FIT + sDNA and APCS scoring + sDNA test schemes had sensitivities of 62.5% and 95.8%, respectively. The APCS score + sDNA test scheme had a sensitivity of 91.1% for nonadvanced adenoma. Conclusion: The FIT + sDNA test scheme demonstrated superior diagnostic efficacy, and the combined APCS score + FIT + sDNA test scheme improved CRC screening efficiency and sensitivity for detecting positive lesions.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Oncology
Kenechukwu Chudy-Onwugaje, Wen-Yi Huang, L. Joseph Su, Mark P. Purdue, Christine C. Johnson, Lingxiao Wang, Hormuzd A. Katki, Kathryn Hughes Barry, Sonja I. Berndt
Summary: In this study, a beneficial role for both aspirin and ibuprofen in preventing advanced adenoma and curbing progression to recurrence and cancer among older adults was observed during long-term follow-up.
Article
Gastroenterology & Hepatology
Uri Ladabaum, John Shepard, Ajitha Mannalithara
Summary: The study analyzed colonoscopy volumes and lesion detection rates before and after the endorsement of colorectal cancer (CRC) screening at 45-49 years of age. It found that lowering the screening initiation age had a modest effect on colonoscopy volume without compromising screening yield, and the detection rates for lesions in the 45-49 age group were similar to those in older age groups. Further national monitoring is needed to fully assess the impact of this change in screening guidelines.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
David E. F. W. M. van Toledo, Emilie C. H. Breekveldt, Joep E. G. IJspeert, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian Ramakers, Iris D. Nagtegaal, Monique E. van Leerdam, Manon C. W. Spaander, Iris Lansdorp-Vogelaar, Esther Toes-Zoutendijk, Evelien Dekker
Summary: This study assessed the detection rate and positive predictive value (PPV) of advanced serrated polyps (ASPs) in a FIT-based screening program. The results showed that 5.9% of FIT-positive screenees had ASPs, and including ASPs slightly increased the yield of the screening.
Article
Gastroenterology & Hepatology
Ahmad Albshesh, Offir Ukashi, Adi Lahat, Uri Kopylov, Nir Horesh, Barak Pflantzer, Ido Laish
Summary: This study aimed to investigate the influence of previous colonoscopy on postdiverticulitis colonoscopic findings in patients with diverticulitis. It was found that diverticulitis patients without previous colonoscopy had a higher incidence of adenoma and colorectal cancer compared to a healthy control group. However, in patients who had previous colonoscopy, there were almost no cases of adenoma or cancer.
COLORECTAL DISEASE
(2023)