Article
Gastroenterology & Hepatology
Saranya Sasidharan, Alexa N. Sasson, Kevin M. Shannon, Ashwin N. Ananthakrishnan
Summary: This study assessed the predictive efficacy of fecal calprotectin in identifying the need for medical or surgical therapy in patients with acute severe colitis. The results demonstrated that patients with higher fecal calprotectin levels were more likely to require in-hospital medical rescue therapy or surgery. This predictive marker has the potential to facilitate earlier therapeutic interventions and improve patient outcomes.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Medicine, General & Internal
Fang Chen, Yue Hu, Yi-Hong Fan, Bin Lv
Summary: This study demonstrated the clinical significance of fecal calprotectin in evaluating endoscopic patterns and clinical manifestation in ulcerative colitis patients. The cut-off value of 164 μg/g for FC concentration was found to predict clinical active disease with high sensitivity and specificity. However, further large-scale studies are needed to confirm the reliability of the cut-off value.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Ludimilla dos Reis Malvao, Kalil Madi, Barbara Cathala Esberard, Renata Fernandes de Amorim, Kelly dos Santos Silva, Katia Farias e Silva, Heitor Siffert Pereira de Souza, Ana Teresa Pugas Carvalho
Summary: Fecal calprotectin concentration can predict mucosal healing in patients with ulcerative colitis, especially when the concentration is below 100 µg/g. There is a positive correlation between FC concentration and colonic mucosal inflammatory status and deep remission.
Review
Medical Laboratory Technology
Jennifer Murray, Klaartje B. Kok, Ruth M. Ayling
Summary: Inflammatory bowel disease (IBD) is a group of chronic conditions characterized by inflammation of the gastrointestinal tract. Endoscopy is the gold standard for diagnosis of IBD, but it is invasive and costly. Fecal calprotectin has been proven to be an accurate surrogate marker for intestinal inflammation in IBD.
CLINICAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Rui-Bin Li, Chun-Qiang Li, Shi-Yao Zhang, Kai-Yu Li, Zhi-Cheng Zhao, Gang Liu
Summary: This study suggests that fecal calprotectin (FC) concentration can be used as a clinical indicator for diagnosing and assessing the risk of pouchitis in patients with ulcerative colitis. Regular FC measurement is recommended for monitoring pouchitis. An FC concentration in the range of 143.25-579.60μg/g indicates a high risk for pouchitis, requiring further examination and preventive treatment.
ANNALS OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Gionata Fiorino, Silvio Danese, Laurent Peyrin-Biroulet, Miquel Sans, Fabrizio Bonelli, Mariella Calleri, Claudia Zierold, Roberta Pollastro, Fabio Moretti, Alberto Malesci
Summary: This study demonstrates that measuring FC levels with the LIAISON (R) Calprotectin assay before relapse can predict relapse in patients with quiescent UC. Furthermore, the accuracy of prediction can be improved using machine learning methods and including other variables in the algorithm.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Chenthan Krishnakumar, Ashwin N. Ananthakrishnan, Brendan M. Boyle, Anne M. Griffiths, Neal S. LeLeiko, David R. Mack, James F. Markowitz, Joel R. Rosh, Cary G. Sauer, Thomas D. Walters, Erin Bonkowski, Lee A. Denson, Jeffrey S. Hyams, Subra Kugathasan
Summary: This study suggests that longitudinal changes in fecal calprotectin levels may be better predictors of 1-year clinical outcomes in children with newly diagnosed ulcerative colitis than baseline values.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Heather J. Galipeau, Alberto Caminero, Williams Turpin, Miriam Bermudez-Brito, Alba Santiago, Josie Libertucci, Marco Constante, Juan Antonio Raygoza Garay, Gaston Rueda, Sarah Armstrong, Alex Clarizio, Michelle Smith, Michael G. Surette, Premysl Bercik, Kenneth Croitoru, Elena F. Verdu
Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.
Article
Gastroenterology & Hepatology
Xiaoqi Ye, Ying Wang, Harry H. X. Wang, Rui Feng, Ziyin Ye, Jing Han, Li Li, Zhirong Zeng, Minhu Chen, Shenghong Zhang
Summary: FC is a valuable biomarker for assessing histological activity in patients with UC, with good sensitivity and specificity for evaluating histological response and remission. Studies using Nancy Index showed higher accuracy of FC, and higher sensitivity was observed when FC cutoff values were >100 mcg/g.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Thomas M. Goodsall, Alice S. Day, Jane M. Andrews, Andrew Ruszkiewicz, Christopher Ma, Robert Bryant
Summary: This cohort study compared the histological and intestinal ultrasound activity of ulcerative colitis in patients undergoing endoscopy. It found that a composite of intestinal ultrasound and fecal calprotectin could accurately predict histological activity in ulcerative colitis, providing a noninvasive marker for disease activity.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pharmacology & Pharmacy
M. V. Ardelean, N. R. Kundnani, A. Sharma, M. Dumitru, R. Buzas, C. I. Rosca, D. Dahdal, N. Ottman, O. F. Ardelean, D. -S. Daniel-marius, M. I. Stelian, D. Lighezan
Summary: This study aimed to explore the correlation between fecal calprotectin (FC) levels and age, alcohol consumption, and beta blocker use in microscopic colitis (MC) patients. The results showed that high levels of FC concentrations were associated with increased risk of diarrhea flare-ups and worsened quality of life. Therefore, frequent monitoring of FC concentrations and preventive measures should be taken to improve the quality of life for these patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pediatrics
Manar Matar, Rachel Levi, Maya Zvuloni, Raanan Shamir, Amit Assa
Summary: This study aimed to assess the effect of anti-TNF alpha therapy on fecal calprotectin (FC) levels in children with inflammatory bowel disease (IBD). The results showed that the majority of patients achieved improvement in FC levels within a short period of time, but normalization of FC in responders required almost one year. The shorter the time from diagnosis to treatment, the faster the improvement in FC levels.
PEDIATRIC RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Akshita Gupta, Amy Yu, Laurent Peyrin-Biroulet, Ashwin N. Ananthakrishnan
Summary: In patients with UC in endoscopic remission, persistent histologic activity is associated with higher rates of relapse. Greater degree of normalization may have a stronger impact. Individual histologic features such as basal plasmacytosis, neutrophilic infiltrations, mucin depletion, and crypt architectural irregularities predicted relapse.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kousaku Kawashima, Naoki Oshima, Kenichi Kishimoto, Masatoshi Kataoka, Mai Fukunaga, Satoshi Kotani, Hiroki Sonoyama, Akihiko Oka, Yoshiyuki Mishima, Hideaki Kazumori, Noriyoshi Ishikawa, Asuka Araki, Shunji Ishihara
Summary: This study aimed to determine the optimal FC cutoff value for predicting HH in UC patients and investigate FC's predictability for prolonged CR. The results showed that FC levels < 82 μg/g can predict HH in UC patients with clinical and endoscopic remission, and low FC also leads to prolonged CR.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medicine, General & Internal
Gonzalo Hijos-Mallada, Raul Velamazan, Raul Marti, Eduardo Chueca, Samantha Arechavaleta, Alberto Lue, Fernando Gomollon, Angel Lanas, Carlos Sostres
Summary: The study found that using a four-biomarker point-of-care test could effectively monitor the inflammatory activity in IBD patients, with fecal calprotectin showing the best sensitivity. Patients with negative results in all four biomarkers had a 100% negative predictive value, while those with all four biomarkers positive had a 100% positive predictive value of endoscopic inflammatory activity.
Article
Gastroenterology & Hepatology
Rohit Jogendran, Parul Tandon, Karen I. Kroeker, Levinus A. Dieleman, Vivian Huang
Summary: The study found that longer disease duration and preconception IBD-related therapy may be associated with increased pregnancy-related knowledge. A dedicated pregnancy clinic can improve reproductive knowledge in women with IBD.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Neurosciences
Asma Salari-Moghaddam, Saeedeh Nouri-Majd, Forough Shakeri, Ammar Hassanzadeh Keshteli, Sanaz Benisi-Kohansal, Mohammad Saadatnia, Ahmad Esmaillzadeh
Summary: The study showed that adherence to the MIND diet was inversely associated with the odds of stroke in a case-control study. After adjusting for BMI, it was found that those with the highest adherence to the MIND diet had a 59% reduced odds of stroke compared to those with the lowest adherence. Further research is needed to validate these findings.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Neurosciences
Lais Bhering Martins, Jenneffer Rayane Braga Tibaes, Ana Maria dos Santos Rodrigues, Ammar Hassanzadeh Keshteli, Carolina Karam Vono, Julia Borges e Borges, Paula Martins Horta, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: This study found that patients with migraine have lower diet quality and higher Dietary Inflammatory Index (DII) compared to healthy controls. However, the scores of diet quality and DII were not correlated with migraine frequency and severity.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Parul Tandon, Eugenia Lee, Rohit Jogendran, Karen Kroeker, Levinus A. Dieleman, Brendan Halloran, Karen Wong, Keri-Ann Berga, Vivian Huang
Summary: This study investigates breastfeeding practices in mothers with inflammatory bowel disease (IBD) and finds that approximately half of the patients discontinue breastfeeding after 6 months postpartum. The common reasons for discontinuation include perceived insufficient milk production and concerns about medication.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Natasha Bollegala, Melanie Barwick, Nancy Fu, Anne M. Griffiths, Laurie Keefer, Sara Ahola Kohut, Karen I. Kroeker, Sally Lawrence, Kate Lee, David R. Mack, Thomas D. Walters, Jacqueline de Guzman, Claudia Tersigni, Ashleigh Miatello, Eric I. Benchimol
Summary: The study is a multi-center randomized controlled trial to evaluate the clinical effectiveness of a multimodal intervention for adolescents and young adults with IBD in Canada. The intervention program includes individualized assessment, transition navigator, virtual patient skills-building, and a virtual structured education program. The control group will receive standard-of-care defined by each center.
BMC GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Narges Ghorbani Bavani, Zahra Hajhashemy, Parvane Saneei, Ammar Hassanzadeh Keshteli, Ahmad Esmaillzadeh, Peyman Adibi
Summary: This study found a relationship between meal regularity and the prevalence of irritable bowel syndrome (IBS). Participants with regular meal patterns had a lower risk of developing IBS, particularly women and individuals with normal weight.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Grace Wang, Parul Tandon, Nicole Rodriguez, Lindsy Ambrosio, Reed T. Sutton, Levinus A. Dieleman, Karen Kroeker, Vivian Huang
Summary: Clinical disease activity is a consistent negative predictor of HRQoL from conception to 12 months postpartum. Patients with UC experience better preconception HRQoL but suffer worse postpartum HRQoL than those with CD.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Allison Bihari, Lily Olayinka, Karen Kroeker
Summary: This scoping review aimed to summarize the literature on outcomes surrounding transition from pediatric to adult care in patients with IBD. Most studies evaluated transition outcomes based on themes of health care utilization and disease management. Future research should focus on engaging patients along with providers to create a consensus on indicators of transition success.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Ammar Hassanzadeh Keshteli, Rosica Valcheva, Cheryl Nickurak, Heekuk Park, Rupasri Mandal, Kendall van Diepen, Karen I. Kroeker, Sander Veldhuyzen van Zanten, Brendan Halloran, David S. Wishart, Karen L. Madsen, Levinus A. Dieleman
Summary: The study reveals that dietary modifications, including increased intake of anti-inflammatory foods and decreased intake of pro-inflammatory foods, are associated with metabolic and microbial changes in ulcerative colitis patients in clinical remission, effectively preventing subclinical inflammation.
Article
Biochemistry & Molecular Biology
Richard Y. Wu, Karren Xiao, Naomi Hotte, Parul Tandon, Yesmine Elloumi, Lindsy Ambrosio, Garett Dunsmore, Shokrollah Elahi, Karen Kroeker, Levinus A. Dieleman, Karen L. Madsen, Vivian Huang
Summary: This study conducted a longitudinal analysis of cytokines in healthy pregnant women and pregnant women with IBD, and found that maternal serum cytokines during pregnancy are influenced by IBD, disease activity, and medications. Active UC was associated with an elevation in IL-21, while active CD was associated with elevated IFN-gamma, IL-6, and IL-21. Additionally, T1 serum cytokine levels of IL-22 and IL-6 were correlated with worse IBD disease activity throughout pregnancy in women with UC and CD, respectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Informatics
Sergio Zepeda-Gomez, Andrea Davila-Cervantes, Aldo J. Montano-Loza, David Yang, Daniel C. Baumgart, Karen Kroeker, Brendan P. Halloran
Summary: This study evaluated the functionality, usefulness, and user satisfaction of a smartphone app developed by the University of Alberta for tracking and documenting procedures in gastrointestinal endoscopy. The app proved to be useful in collecting meaningful data and creating graphs and tables to calculate key performance indicators.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Pediatrics
Alice Foster, Justin M. Chan, Eytan Wine, Wael El-Matary, Matthew W. Carroll, Karen I. Kroeker, Jennifer C. Debruyn, Cynthia H. Seow, Sally Lawrence, Kathy Evans, Cheryl Kluthe, Nastaran Sharifi, Christina Pears, Simone Nicol, Lily Olayinka, Nancy Fu, Hien Q. Huynh, Brian Bressler, Charles N. Bernstein, Kevan Jacobson
Summary: This study examined the readiness of adolescents and young adults with inflammatory bowel disease (IBD) to transition to adult care. The results showed that a large proportion of AYAs lacked the knowledge and skills necessary for transition to adult care. Therefore, assessment tools for transition readiness are essential to identify deficits in knowledge and behavior skills that can be addressed by the youth, caregivers, and multidisciplinary team.
JOURNAL OF PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Farhad Peerani, Makayla Watt, Kathleen P. Ismond, Reid Whitlock, Lindsy Ambrosio, Naomi Hotte, Nicholas Mitchell, Robert J. Bailey, Karen Kroeker, Levinus A. Dieleman, Jesse Siffledeen, Allen Lim, Karen Wong, Brendan P. Halloran, Daniel C. Baumgart, Lorian Taylor, Maitreyi Raman, Karen L. Madsen, Puneeta Tandon
Summary: Psychological stress has a negative impact on the outcomes of inflammatory bowel disease (IBD). A 12-week online multicomponent stress reduction intervention has shown significant efficacy in improving perceived stress, mental health, and quality of life in IBD patients. The program was well adopted and adhered to by the participants, demonstrating its potential importance in the future treatment of IBD.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Makayla Watt, Farhad Peerani, Karen Madsen, Jesse Siffledeen, Karen Kroeker, Allen Lim, Puneeta Tandon, Ashley Hyde
Summary: The qualitative study showed that IBD was a significant source of stress, with participation in a novel 12-week online mental wellness program serving to decrease participants' symptoms and increase their perceived ability to manage stress.
CROHNS & COLITIS 360
(2022)