Article
Multidisciplinary Sciences
Nutta Iadsee, Natthaya Chuaypen, Teerasit Techawiwattanaboon, Thananya Jinato, Tanisa Patcharatrakul, Songphol Malakorn, Aisawan Petchlorlian, Kearkiat Praditpornsilpa, Kanitha Patarakul
Summary: This study compared the gut microbiota profiles of Thai volunteers over 50 years of age, divided into three groups: CRC patients, adenomatous polyp patients, and healthy controls. The results showed significant differences in the mucosal microbiota among the groups, with a stepwise increase of Bacteroides and Parabacteroides according to the adenomas-carcinomas sequence. The study also identified the presence of the opportunistic pathogen Erysipelatoclostridium ramosum (ER) in CRC patients and suggested it as a potential noninvasive biomarker for CRC screening.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Julia L. Drewes, Jie Chen, Nicholas O. Markham, Reece J. Knippel, Jada C. Domingue, Ada J. Tam, June L. Chan, Lana Kim, Madison McMann, Courtney Stevens, Christine M. Dejea, Sarah Tomkovich, John Michel, James R. White, Fuad Mohammad, Victoria L. Campodonico, Cody N. Heiser, Xinqun Wu, Shaoguang Wu, Hua Ding, Patricia Simner, Karen Carroll, Martha J. Shrubsole, Robert A. Anders, Seth T. Walk, Christian Jobin, Fengyi Wan, Robert J. Coffey, Franck Housseau, Ken S. Lau, Cynthia L. Sears
Summary: This study reveals the role of toxigenic Clostridioides difficile in promoting colorectal cancer, suggesting that chronic colonization with this pathogenic bacteria may drive tumor development through the induction of Wnt signaling, reactive oxygen species, and protumorigenic mucosal immune responses.
Article
Microbiology
Orazio Palmieri, Stefano Castellana, Anna Latiano, Tiziana Latiano, Annamaria Gentile, Anna Panza, Marianna Nardella, Davide Ciardiello, Tiziana Pia Latiano, Giuseppe Corritore, Tommaso Mazza, Francesco Perri, Giuseppe Biscaglia
Summary: An increasing amount of evidence suggests the important role of gut microbiota in the development of colorectal cancer. This study analyzed the microbial communities in normal and neoplastic colonic mucosa using NGS and metagenomics analysis tools. The findings revealed weak differences in microbial diversity between CRC and control groups, with an increasing trend of Rikenellaceae, Pseudomonas, and Fusobacterium in CRC. Fusobacterium nucleatum was found to be significantly enriched in all tissues of subjects with synchronous colorectal neoplasia.
Article
Gastroenterology & Hepatology
Yuan Cao, Jifeng Wang, Weiliang Hou, Yanqiang Ding, Yefei Zhu, Jiayi Zheng, Qiongyi Huang, Zhan Cao, Ruting Xie, Qing Wei, Huanlong Qin
Summary: The gut microbiome is linked to the occurrence and development of colorectal cancer (CRC), and specific features of expressed T cell receptor (TCR) beta repertoires in CRC patients were identified. The relative abundance of certain microorganisms was consistently elevated in CRC patients compared to healthy individuals. The correlation between somatic mutations, TCR clonality, and microbial biomarkers in CRC was investigated, leading to the construction of a classifier for clinical detection of CRC based on the microbiome and TCR repertoires.
Article
Cell Biology
Jiali Dong, Yuan Li, Huiwen Xiao, Shuqin Zhang, Bin Wang, Haichao Wang, Yiliang Li, Saijun Fan, Ming Cui
Summary: The study reveals that alterations in the oral microbiota can impact the therapeutic efficacy and prognosis of radiotherapy for CRC, with specific antibiotics potentially mitigating these effects. Furthermore, the oral microbiome, in conjunction with intestinal microbes, collectively influences the efficacy and prognosis of radiotherapy for CRC.
Article
Microbiology
Caitlin A. Brennan, Geicho Nakatsu, Carey Ann Gallini Comeau, David A. Drew, Jonathan N. Glickman, Robert E. Schoen, Andrew T. Chan, Wendy S. Garrett
Summary: The study demonstrates that aspirin has specific antibacterial effects on Fusobacterium nucleatum, a bacterium associated with colorectal cancer. Individuals who use aspirin daily have lower levels of this bacterium in colon adenoma tissues. This suggests the potential for aspirin to modulate bacteria in vivo for improved colorectal cancer outcomes.
Article
Oncology
Yoshimitsu Shimomura, Ling Zha, Sho Komukai, Nobuhiro Narii, Tomotaka Sobue, Tetsuhisa Kitamura, Satoshi Shiba, Sayaka Mizutani, Takuji Yamada, Norie Sawada, Shinichi Yachida
Summary: Higher fiber intake is associated with a lower risk of colorectal cancer. The study found that certain intestinal bacteria, including Fusobacterium nucleatum and Gemella morbillorum, mediate the relationship between fiber intake and CRC risk.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Thyra Lowenmark, Anna Lofgren-Burstrom, Carl Zingmark, Ingrid Ljuslinder, Michael Dahlberg, Sofia Edin, Richard Palmqvist
Summary: This study investigates the associations of two colorectal cancer-related bacteria, Parvimonas micra and Fusobacterium nucleatum, with survival in colorectal cancer patients. The results suggest that patients with high tumoural levels of Parvimonas micra have decreased survival, and both Parvimonas micra and Fusobacterium nucleatum are associated with different clinicopathological and tumour molecular traits.
Article
Gastroenterology & Hepatology
Na Wu, Yu-Qing Feng, Na Lyu, Di Wang, Wei-Dong Yu, Yong-Fei Hu
Summary: In this study, it was demonstrated that F. nucleatum infection altered the colon mucosal microbiota by enriching pathogens related to the development of CRC, providing new insights into the role of F. nucleatum in the oncogenic microbial environment of the colon.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Jiali Chen, Pai Zhang, Yan Zhao, Jie Zhao, Xiaobo Wu, Ruijia Zhang, Ruitao Cha, Qingxin Yao, Yuan Gao
Summary: This study developed a nitroreductase-instructed supramolecular self-assembly system to enhance the sensitivity of colorectal cancer cells to chemotherapy drugs by agglutinating and eliminating F. nucleatum bacteria. The local introduction of these assemblies efficiently inhibited tumor growth in mice bearing F. nucleatum-infected colorectal cancer. This study broadens the application range of enzyme-instructed supramolecular self-assembly and provides a new approach to treat CRC.
Review
Oncology
Maryam Ranjbar, Rasoul Salehi, Shaghayegh Haghjooy Javanmard, Laleh Rafiee, Habibollah Faraji, Sima Jafarpor, Gordon A. Ferns, Majid Ghayour-Mobarhan, Mostafa Manian, Reza Nedaeinia
Summary: Colorectal cancer is a common global cancer with emerging links to gut microbiota and cellular changes. Genetic factors contribute less to CRC compared to environmental and epigenetic factors. Fusobacterium nucleatum may serve as a prognostic biomarker for CRC risk.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Jessica Roelands, Peter J. K. Kuppen, Eiman I. Ahmed, Raghvendra Mall, Tariq Masoodi, Parul Singh, Gianni Monaco, Christophe Raynaud, Noel F. C. C. de Miranda, Luigi Ferraro, Tatiana C. Carneiro-Lobo, Najeeb Syed, Arun Rawat, Amany Awad, Julie Decock, William Mifsud, Lance D. Miller, Shimaa Sherif, Mahmoud G. Mohamed, Darawan Rinchai, Marc Van den Eynde, Rosalyn W. Sayaman, Elad Ziv, Francois Bertucci, Mahir Abdulla Petkar, Stephan Lorenz, Lisa Sara Mathew, Kun Wang, Selvasankar Murugesan, Damien Chaussabel, Alexander L. Vahrmeijer, Ena Wang, Anna Ceccarelli, Khalid A. Fakhro, Gabriele Zoppoli, Alberto Ballestrero, Rob A. E. M. Tollenaar, Francesco M. Marincola, Jerome Galon, Souhaila Al Khodor, Michele Ceccarelli, Wouter Hendrickx, Davide Bedognetti
Summary: The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, comprehensive genomic analyses were performed on fresh-frozen samples from 348 patients with primary colon cancer. The study revealed a gene expression signature called Immunologic Constant of Rejection that outperformed conventional prognostic molecular biomarkers. Additionally, a favorable outcome was associated with a microbiome signature driven by Ruminococcus bromii.
Article
Cell Biology
Han Yin, Zhuangzhuang Miao, Lu Wang, Beibei Su, Chaofan Liu, Yu Jin, Bili Wu, Hu Han, Xianglin Yuan
Summary: This study investigated the contribution of F. nucleatum to the microbiota-liver axis of CRC in mice, and found that F. nucleatum may promote CRC liver metastasis by triggering liver immunity through the regulation of gut microbiota structure and composition.
Review
Cell Biology
Jose Guilherme Datorre, Ana Carolina de Carvalho, Denise Peixoto Guimaraes, Rui Manuel Reis
Summary: Colorectal cancer is a prevalent and deadly neoplasm worldwide, with genetic, lifestyle, and inflammation being important risk factors. Recent studies support the significant role of the intestinal microbiome in CRC carcinogenesis, with dysbiosis frequently observed in patients. Bacterial strains like Fusobacterium nucleatum in CRC patients' tissues are associated with clinical features and treatment response, highlighting the potential for interventions targeting these microbial imbalances.
Article
Microbiology
Minyu Wang, Zheng Wang, Duncan James Lessing, Min Guo, Weihua Chu
Summary: F. nucleatum and its metabolite hydrogen sulfide can modulate intestinal microbiota and autophagy to promote the development and progression of colorectal cancer.
MICROBIOLOGY SPECTRUM
(2023)
Review
Nutrition & Dietetics
Ameer Al-Hadidi, Jason Navarro, Steven D. Goodman, Michael T. Bailey, Gail E. Besner
Summary: Necrotizing enterocolitis (NEC) is a devastating disease mainly found in premature infants, associated with gastrointestinal dysbiosis. Probiotics have been proposed as a new avenue for therapy, with a novel enterally delivered formulation showing promise in experimental models of NEC.
Article
Gastroenterology & Hepatology
Salman S. Salman, Kent C. Williams, Pedro Marte-Ortiz, Wolfgang Rumpf, Lauren Mashburn-Warren, Christian L. Lauber, Michael T. Bailey, Ross M. Maltz
Summary: In this study, PEG3350 and magnesium citrate significantly affected stool consistency and gut microbiome diversity, but did not alter anxiety-like behaviors in mice that were administered with low or high doses.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Chemistry, Analytical
Li Chen, Xiaowei Sun, Amrik Singh Khalsa, Michael T. Bailey, Kelly Kelleher, Colleen Spees, Jiangjiang Zhu
Summary: A quantitative method was developed for accurate and reliable analysis of SCFAs, which was applied to determine the SCFA concentrations and compositions in fecal samples from study subjects. A broad range of concentrations was noted for the detected SCFAs.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Immunology
Rosie Shrout, Annelise A. Madison, Megan E. Renna, Catherine M. Alfano, Stephen P. Povoski, Adele M. Lipari, Doreen M. Agnese, William E. Carson, William B. Malarkey, Michael T. Bailey, Janice K. Kiecolt-Glaser
Summary: Satisfying relationships among breast cancer survivors are associated with lower gut permeability and inflammation levels, leading to improved physiological health. This type of relationship can help reduce disease risks and enhance quality of life.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Ross M. Maltz, Pedro Marte-Ortiz, Therese A. Rajasekera, Brett R. Loman, Tamar L. Gur, Michael T. Bailey
Summary: Stressor exposure increases colonic inflammation and leads to anxiety-like behavior. Mice recovering from colitis showed increased anxiety-like behavior after exposure to stressor, which correlated with elevated IL-17A levels in the serum and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Jacob M. Allen, Amy R. Mackos, Robert M. Jaggers, Patricia C. Brewster, Mikaela Webb, Chia-Hao Lin, Chris Ladaika, Ronald Davies, Peter White, Brett R. Loman, Michael T. Bailey
Summary: Psychological stress alters the gut microbiota and increases the risk for enteric infections and chronic bowel conditions. Stress disrupts colonic epithelial cells and mucosal integrity, leading to dysbiosis in the gut microbiota.
Article
Oncology
Brett R. Loman, Kathryn L. G. Russart, Corena Grant, Alexis J. Lynch, Michael T. Bailey, Leah M. Pyter
Summary: This study examines the effects of orthotopic mammary tumor implantation, growth, and resection on fecal bacteriome composition and intestinal barrier function in relation to systemic inflammation and enteric bacterial translocation in mice. The results indicate that mammary tumors can alter the microbiome, reduce intestinal barrier function, increase translocation of enteric bacteria, and induce systemic inflammation.
Article
Immunology
Robert M. Jaggers, Damon J. DiSabato, Brett R. Loman, Danica Kontic, Kyle D. Spencer, Jacob M. Allen, Jonathan P. Godbout, Ning Quan, Tamar L. Gur, Michael T. Bailey
Summary: Commensal microbes are impacted by stressor exposure and are known contributors to cognitive and social behaviors. This study found that stressor-induced cognitive deficits involve enhanced bacterial interaction with the intestine, leading to low-grade, CD14-dependent inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Food Science & Technology
Haley A. Chatelaine, Cynthia A. Ramazani, Kyle Spencer, Susan Olivo-Marston, Michael T. Bailey, Joseph McElroy, Emmanuel Hatzakis, Ewy A. Mathe, Rachel E. Kopec
Summary: This study compared the metabolomes associated with high-fat versus energy-restricted diets in early colorectal cancer models using a murine model. The results indicated that recent diet is more closely related to the colon metabolome, especially lipid metabolism, providing potential biomarkers for early CRC development and highlighting the importance of early diet in influencing pre-CRC risk.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Psychiatry
Desiree R. Delgadillo, Sarah D. Pressman, Lisa M. Christian, Jeffrey D. Galley, Michael T. Bailey
Summary: This study examines the association between prosocial-self-regulating temperaments and the gut microbiome in typically developing children. The results suggest that certain microbes may be linked to prosocial behaviors used to regulate emotion in these children.
PSYCHOSOMATIC MEDICINE
(2022)
Review
Immunology
Mecklin V. Ragan, Samantha J. Wala, Steven D. Goodman, Michael T. Bailey, Gail E. Besner
Summary: This article introduces a new delivery system for L. reuteri that enhances the efficacy of the probiotic by inducing biofilm formation. The study shows promising results in rat and mouse models, demonstrating the preventive and therapeutic effects of L. reuteri in its biofilm state. Furthermore, an ongoing clinical trial may support the future use of L. reuteri in preventing NEC in preterm infants.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Neurosciences
Helen J. Chen, Allison Bischoff, Jeffrey D. Galley, Lauren Peck, Michael T. Bailey, Tamar L. Gur
Summary: Psychosocial stress during pregnancy can affect the immune function of both mothers and offspring, and the gut microbiome may play a role in this process. This study reveals that maternal stress and antimicrobial treatment independently influence maternal and offspring immunity, with some distinct effects.
NEUROBIOLOGY OF STRESS
(2022)
Article
Gastroenterology & Hepatology
Emily B. Hill, Li Chen, Michael T. Bailey, Amrik Singh Khalsa, Ross Maltz, Kelly Kelleher, Colleen K. Spees, Jiangjiang Zhu, Brett R. Loman
Summary: Low-resource individuals are at higher risk of obesity and cardiovascular disease due to poor dietary patterns and dysfunctional microbiota. This study targeted low-resource caregiver-child dyads and conducted a multifaceted lifestyle intervention, which showed improvements in dietary patterns, reduced CVD risk factors, and altered microbiome composition.
Article
Nutrition & Dietetics
Amrik Singh Khalsa, Jonathan Burton, Michael T. T. Bailey, Jiangjiang Zhu, Kelly J. J. Kelleher, Ross M. M. Maltz, Brett R. R. Loman, Colleen K. K. Spees
Summary: This study describes the feasibility of collecting non-invasive human biospecimens (stool, urine, and hair) from parents and children in low-resource neighborhoods as part of a non-traditional garden research setting. Future research will report findings related to the mechanisms between diet, microbiome, metabolites, and clinical outcomes.
Article
Pediatrics
Mecklin V. Ragan, Samantha J. Wala, Nitin Sajankila, Audrey F. Duff, Yijie Wang, Samuel G. Volpe, Ameer Al-Hadidi, Zachary Dumbauld, Nanditha Purayil, Joseph Wickham, Miriam R. Conces, Belgacem Mihi, Steven D. Goodman, Michael T. Bailey, Gail E. Besner
Summary: This article introduces an enteral-feed only piglet model of NEC and introduces a new multifactorial D-NEC scoring system to assess the severity of the disease. Piglets with NEC had microbiome changes consistent with clinical cases. This model can be used to test novel therapies for treating and preventing this devastating disease.
FRONTIERS IN PEDIATRICS
(2023)