Article
Engineering, Chemical
Erick Jarles Santos Araujo, Eupidio Scopel, Camila Alves Rezende, Julian Martinez
Summary: Supercritical impregnation (SFI) can be used to load polyphenols into corn starch aerogels, creating new delivery systems for the food industry. This study examined the effects of SFI pressure and temperature on the loading of polyphenols from passion fruit bagasse into corn starch aerogels. The best SFI condition for total phenolics and antioxidant capacity was found to be 65 degrees C/37.5 MPa. The efficiency of SFI was confirmed by the decrease in aerogel surface area, volume, and particle diameter.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Margarita S. Rubina, Anastasiya A. Pestrikova, Polina S. Kazaryan, Alexander Y. Nikolaev, Ivan S. Chaschin, Natalia A. Arkharova, Alexandra V. Shulenina, Marina A. Pigaleva
Summary: Chitosan sponges with open porous structures are promising drug delivery matrices for transdermal patches. The supercritical solvent impregnation (SSI) technique using scCO2/ethanol medium was employed to investigate the loading capacity of 17 beta-estradiol (E2) into chitosan sponges. The study found that the hormone loading increased proportionally with E2 concentration and CO2 density. Characterization techniques confirmed the successful inclusion of E2 in the polymer matrices, with uniform distribution and micronized crystallites achieved by the SSI method.
JOURNAL OF CO2 UTILIZATION
(2022)
Article
Chemistry, Physical
Lu Wang, Qiong Wu, Baozheng Zhao, Zelin Li, Yuehong Zhang, Lang Huang, Shitao Yu
Summary: Carbon aerogels prepared from chitosan with ionic liquid as solvent and nitrogen source are functionalized through various post-treatments for applications in fluorescence, electrode materials, and catalyst support. The resulting materials exhibit unique properties such as water solubility, excellent capacitance for supercapacitors, and high catalytic activity for phenol hydrogenation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Nanoscience & Nanotechnology
Mengyao Dong, Gang Wang, Xiangning Zhang, Daqing Tan, D. Jaya Prasanna Kumar, Juanna Ren, Henry Colorado, Hua Hou, Zhexenbek Toktarbay, Zhanhu Guo
Summary: Compared with unfoamed polymers, polymer foams have many advantages such as lightweight, high strength-to-weight ratio, and excellent insulation properties. The use of chemical foaming agents in conventional polymer foam preparation raises environmental issues. Supercritical fluids, known for their environmentally friendly and non-toxic characteristics, can serve as an alternative to conventional chemical foaming agents. They exhibit gas-like diffusion and liquid-like density, allowing for the production of uniform and higher-density microcellular foams.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Sizhao Zhang, Junpeng He, Shixian Xiong, Qi Xiao, Yunyun Xiao, Feng Ding, Hui Ji, Zhouyuan Yang, Zhengquan Li
Summary: The study introduces a new method to enhance the structure of chitosan aerogels by introducing cellulose nanocrystals, improving the specific surface area and compressive strength, as well as enhancing the thermal insulation property of the aerogels.
Review
Green & Sustainable Science & Technology
Lei Li, Minyi Chen, Yun Zeng, Gang Liu
Summary: Supercritical fluid extraction (SFE) is an eco-friendly technology with significant application potential in the food and nutraceutical industries. SFE has high selectivity and can be used to extract easily oxidized compounds, while minimizing the use of organic solvents and leaving no toxic residues in the product.
ADVANCED SUSTAINABLE SYSTEMS
(2022)
Review
Biochemistry & Molecular Biology
Dario Rodrigues do Nascimento Junior, Antonio Tabernero, Elaine Christine de Magalhaes Cabral Albuquerque, Silvio Alexandre Beisl Vieira de Melo
Summary: This review examines the encapsulation processes for biopesticides and highlights the use of supercritical fluid technology (SFT) for encapsulating biopesticides. It also discusses the potential and prospects of using SFT in the field, as well as the challenges to be overcome in the future.
Article
Biochemistry & Molecular Biology
Coraline Chartier, Sytze Buwalda, Helene Van Den Berghe, Benjamin Nottelet, Tatiana Budtova
Summary: Highly porous chitosan-based materials were prepared using different methods to tune their morphology and properties. The absorption capacity of chitosan cryogels was found to be higher than that of chitosan aerogels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Phuong Tran, Jeong-Sook Park
Summary: Many newly discovered chemical entities in the pharmaceutical industry suffer from low aqueous solubility, leading to poor bioavailability, which poses a challenge for pharmaceutical scientists. Solid dispersion (SD) technology, particularly the use of supercritical fluid (SCF) technology, has been successful in overcoming these challenges and enhancing dissolution and bioavailability of poorly water-soluble drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Wael Hamd, Digambara Patra, Houssam El-Rassy
Summary: The study demonstrates for the first time the loading of curcumin into different metal oxide aerogels, showing enhanced bioavailability and stability for potential therapeutic applications. Additionally, the study uncovers distinct behaviors of curcumin-metal oxide interactions, shedding light on the mechanisms underlying such complexation processes.
Article
Polymer Science
Zhuojian Wang, Fengxia Liu, Wei Wei, Chao Dong, Zhiyi Li, Zhijun Liu
Summary: A semi-continuous supercritical drying process was developed to improve the efficiency of producing polyimide aerogels. The influence of supercritical fluid parameters on the aerogel properties was investigated based on the vapor-liquid equilibrium diagram. The results showed that efficient supercritical drying was crucial for the comprehensive properties of the aerogel, and subcritical drying conditions below the critical mixture pressure also had special interest.
Article
Chemistry, Physical
Konstantinos N. Maroulas, Dimitrios G. Trikkaliotis, Zoi S. Metaxa, Naglaa Abdelall, Abdullah Alodhayb, Ghada A. Khouqeer, George Z. Kyzas
Summary: The study recommends the use of biopolymer-derived aerogels to address oil spills. The aerogels demonstrated high absorption capacity for both water and diesel oil, and they can be effectively used for the oil/water separation process.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Ivana Lukic, Jelena Pajnik, Vanja Tadic, Stoja Milovanovic
Summary: The aim of this study was to utilize supercritical CO2 as a green medium for the development of added-value materials that can be used as phytopharmaceuticals. The study showed that optimized starch aerogels with high porosity can be obtained by varying temperature and pressure, which enables maximal loading capacity for hemp seed extracts. The proposed scCO2-assisted processes demonstrated promising results for the extraction and impregnation of hemp seed flour and oil.
JOURNAL OF CO2 UTILIZATION
(2022)
Review
Chemistry, Multidisciplinary
Satoru Takeshita, Shanyu Zhao, Wim J. Malfait, Matthias M. Koebel
Summary: Chitosan, derived from food waste, is a biopolymer with high biocompatibility and easy chemical processability. Porous chitosan materials vary widely in properties, from supercritically dried mesoporous chitosan aerogels to very light freeze-dried macroporous scaffolds. Despite impressive performance at the laboratory scale, the highly porous nature of chitosan amplifies both its beneficial functionality and drawbacks, posing serious barriers to industrialization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Irina Postnova, Sergey Sarin, Anatoly Zinchenko, Yury Shchipunov
Summary: Recent research has demonstrated that native ds-DNA and chitosan can coassemble to form a translucent homogeneous hydrogel, with extraordinary mechanical properties. These hydrogels and aerogels, due to their biocompatibility, biodegradability, and use of renewable resources, have the potential to replace typical synthetic polymers. Additionally, bionanocomposites with various functionalities can be fabricated, showing potential for applications in areas such as luminescence, sensing, and photocatalysis.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Mo'tasem M. Alsmadi, Rana M. Obaidat, Mohammad Alnaief, Borhan Aldeen Albiss, Nabil Hailat
Article
Energy & Fuels
Mohammad Alnaief, Arwa Sandouqa, Ibrahem Altarawneh, Mohammad Al-Shannag, Malek Alkasrawi, Zayed Al-hamamre
Summary: This study evaluated the adsorption characteristics and potential of bioadsorbent material manufactured by alkali treatment of olive cake, showing that the resultant bioadsorbent could purify biodiesel to meet standards while exhibiting good sorption equilibrium. Freundlich and Temkin isotherms were found to adequately describe the adsorption behavior of the produced bioadsorbent.
Article
Pharmacology & Pharmacy
Rana Obaidat, Haneen Aleih, Hadeia Mashaqbeh, Bashar Altaani, Mo'tasem M. Alsmadi, Mohammad Alnaief
Summary: Masking the bitter taste of ibuprofen using cocoa butter and supercritical fluid technology is a promising innovative approach to enhance patient acceptance, especially for children. The drug to polymer ratio, configuration of the supercritical fluid unit, and preparation method were found to be critical in the formulation of ibuprofen microparticles. Taste evaluation with human volunteers showed that microparticles containing 20% drug, processed with supercritical fluid technology, were effective in masking the bitter taste of ibuprofen.
Article
Biochemistry & Molecular Biology
Muthumanickam Sankar, Balajee Ramachandran, Boomi Pandi, Nachiappan Mutharasappan, Vidhyavathi Ramasamy, Poorani Gurumallesh Prabu, Gowrishankar Shanmugaraj, Yao Wang, Brintha Muniyandai, Subaskumar Rathinasamy, Balakumar Chandrasekaran, Mohammad F. Bayan, Jeyakanthan Jeyaraman, Gurumallesh Prabu Halliah, Solomon King Ebenezer
Summary: The study identified 227 phytocompounds from various medicinal plants and selected 30 active compounds based on their binding affinity against S-ACE2 and M-pro proteins. In silico analyses showed potential binding activity of these compounds against COVID-19, making them promising candidates for novel drug discovery.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Polymer Science
Kumbakonam Balachandran Ilango, Senguttuvan Gowthaman, Kumbakonam Ilango Seramaan, Kumarappan Chidambaram, Mohammad F. Bayan, Mohamed Rahamathulla, Chandrasekaran Balakumar
Summary: The mucilage extracted from Coccinia grandis shows good physicochemical properties and drug performance, making it a potential material for tablet formulation. It is also a promising disintegrant, performing better than standard disintegrants, and has low cytotoxicity, ensuring safety for human cells.
Article
Polymer Science
Mohammad F. Bayan, Saeed M. Marji, Mutaz S. Salem, M. Yasmin Begum, Kumarappan Chidambaram, Balakumar Chandrasekaran
Summary: The study aims to develop a smart drug delivery system based on pH-sensitive polymeric formulations. The system can delay the release of drugs in the stomach and small intestine, while releasing them in the colon, showing promising potential for application.
Article
Biochemistry & Molecular Biology
Mohammad F. Bayan, Abdolelah Jaradat, Mohammad H. Alyami, Abdallah Y. Naser
Summary: This study aimed to develop a new formulation that can both retain and control the release of 5-fluorouracil for targeted medication delivery to treat colorectal cancer. Six polymer-based formulations loaded with 5-fluorouracil were successfully produced using a thermal bulk polymerization method. The formulation's properties, such as glass transition temperature, tensile strength, and swelling behavior, were evaluated. The developed drug delivery system showed promising results by delaying the release of 5-fluorouracil in the upper gastrointestinal tract and controlling its release afterward for potential delivery to the colon.
Article
Engineering, Multidisciplinary
Saeed M. M. Marji, Mohammad F. Bayan, Abdolelah Jaradat
Summary: This study highlights the simple synthesis of methyl gallate encapsulated folate-ZIF-L nanoframeworks (MG@Folate ZIF-L) and its potential applications in biomedical field. The nanoframeworks exhibited superior cytotoxic effect and anti-biofilm potential. With the unique physicochemical and biological characteristics, it overcomes the limitations of existing drug delivery systems and shows promising biomedical applications.
Article
Chemistry, Multidisciplinary
Rajapandi Raju, Kumarappan Chidambaram, Balakumar Chandrasekaran, Tapan Kumar Maity, Abdullah M. Alkahtani, Harish C. Chandramoorthy, Mohammad F. Bayan
Summary: A series of novel isatin hybrids 5a-g were designed, synthesized, and characterized spectroscopically. The synthesized compounds were evaluated for their cytotoxic activity against the human breast cancer cell line (MCF-7) using in vitro MTT assay. Compound 5e, bearing benzyl moiety at N4 piperazine, exhibited the most potent anticancer activity with an IC50 of 12.47 mM. Additionally, compounds 5e and 5g were evaluated for their antitumor activity against Dalton's ascitic lymphoma (DAL) cell line, and compound 5e showed the ability to normalize the blood picture compared to the standard drug. A molecular docking study using the crystal structure of Hsp90 protein provided insights into the protein-ligand interactions and binding mode. The drug-likeliness of the compounds was predicted based on Lipinski's rule of five and pharmacokinetic ADME parameters. Therefore, the synthesized isatin hybrids could serve as promising lead compounds for anticancer drug discovery due to their drug-like properties.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2023)
Review
Infectious Diseases
Rajwinder Kaur, Kirandeep Kaur, Mohammad H. Alyami, Damanpreet Kaur Lang, Balraj Saini, Mohammad F. Bayan, Balakumar Chandrasekaran
Summary: The nature of microorganisms and the efficiency of antimicrobials have exhibited a significant interdependent change in their dynamics in recent decades. Metals and metallic compounds have gained popularity as they have been found effective against various microbial strains. A structured search of research and review papers, as well as other sources such as patents and Clinicaltrials.gov, was conducted for this review. Different microbes and their species and strains were found to be sensitive to metal-carrying formulations, effectively inhibiting growth, multiplication, and biofilm formation. Silver, copper, gold, iron, and gallium were identified as metals with antimicrobial properties. Membrane disruption, oxidative stress, and interaction with proteins and enzymes were identified as primary microbicidal processes.
Article
Polymer Science
Benedict Jose Chellathurai, Ramyadevi Anburose, Mohammad H. H. Alyami, Mohan Sellappan, Mohammad F. F. Bayan, Balakumar Chandrasekaran, Kumarappan Chidambaram, Mohamed Rahamathulla
Summary: The present study aimed to develop and evaluate a polyherbal gel for treating acne by formulating a mixture of Aloe barbadensis pulp and Vigna radiata extract using Carbopol 940, triethanolamine, and propylene glycol as gelling, viscosity modifying, and pH modifying agents respectively. The developed gel exhibited significant antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, with promising inhibition zones. The gel formulation also showed beneficial effects on acne, with the additional benefit of Aloe barbadensis on the skin.
Review
Pharmacology & Pharmacy
Diksha Choudhary, Amritpal Kaur, Pargat Singh, Gaurav Chaudhary, Rajwinder Kaur, Mohammad F. Bayan, Balakumar Chandrasekaran, Saeed M. Marji, Reema Ayman
Summary: This review article summarizes the mechanism, uses, advantages, disadvantages, challenges, and future development aspects of PROTACs as a drug strategy.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Abdalaziz Alwraikat, Abdolelah Jaradat, Saeed M. Marji, Mohammad F. Bayan, Esra'a Alomari, Abdallah Y. Naser, Mohammad H. Alyami
Summary: Measurement of intracellular pH is crucial for detecting diseases, and pH-responsive nanosensors have been developed to detect minor pH changes non-invasively. However, existing nanosensors require harmful organic solvents. This research successfully synthesized pH-responsive alginate nanoparticles using an organic, solvent-free, and environmentally friendly method. The nanosensors showed good pH-responsiveness and stability, making them potential diagnostics for intracellular and extracellular pH measurements.
Article
Polymer Science
M. Alagusundaram, Nem Kumar Jain, M. Yasmin Begum, S. Angala Parameswari, Vinod Kumar Nelson, Mohammad F. Bayan, Balakumar Chandrasekaran
Summary: A promising controlled drug delivery system based on polymeric buccoadhesive bilayered formulation containing nifedipine has been developed. The system showed stable drug release and no irritation or inflammation at the site of administration. The best formulation, NT5, exhibited in vitro and in vivo drug release profiles that mimic the biological membrane.
Review
Biotechnology & Applied Microbiology
Thoa Duong, Clara Lopez-Iglesias, Piotr K. Szewczyk, Urszula Stachewicz, Joana Barros, Carmen Alvarez-Lorenzo, Mohammad Alnaief, Carlos A. Garcia-Gonzalez
Summary: Pulmonary drug delivery using dry powder inhalers offers numerous benefits, with porous particles like aerogel powders showing particularly attractive properties for improving delivery efficiency. The latest advancements in powder technologies for the processing of particulate porous carriers are being explored, with a focus on the use of aerogel technology to achieve superior performance in pulmonary delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)