Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque

Formation of 3D Cholesterol Crystals from 2D Nucleation Sites in Lipid Bilayer Membranes: Implications for Atherosclerosis

(2015) Neta Varsano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of cholesterol crystals in atherosclerosis is unmasked by altering tissue preparation methods

(2015) Mojdeh Nasiri et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events

(2015) Jennifer G. Robinson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

(2015) Christopher P. Cannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eroded Versus Ruptured Plaques at the Culprit Site of STEMI

(2015) Francesco Saia et al.   JACC-Cardiovascular Imaging

Relationship between cholesterol crystals and culprit lesion characteristics in patients with stable coronary artery disease: an optical coherence tomography study

(2014) Shunichi Nakamura et al.   Clinical Research in Cardiology

OxLDL induces endothelial dysfunction and death via TRAF3IP2: Inhibition by HDL3 and AMPK activators

(2014) Anthony J. Valente et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

(2014) E. O. Samstad et al.   JOURNAL OF IMMUNOLOGY

Distinct Morphological Features of Ruptured Culprit Plaque for Acute Coronary Events Compared to Those With Silent Rupture and Thin-Cap Fibroatheroma

(2014) Jinwei Tian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia

(2014) Dirk J. Blom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis

(2013) Brendan M. Everett et al.   AMERICAN HEART JOURNAL

Future of Cholesteryl Ester Transfer Protein (CETP) Inhibitors: A Pharmacological Perspective

(2013) Amir Hooshang Mohammadpour et al.   CLINICAL PHARMACOKINETICS

Inflammation modulates human HDL composition and function in vivo

(2012) Margarita de la Llera Moya et al.   ATHEROSCLEROSIS

Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals

(2012) Hongguang Li et al.   CHEMICAL COMMUNICATIONS

Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease

(2012) Stefan M. Nidorf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Effect of Statins on Cholesterol Crystallization and Atherosclerotic Plaque Stabilization

(2011) George S. Abela et al.   AMERICAN JOURNAL OF CARDIOLOGY

Plaque Rupture and Thrombosis Are Reduced by Lowering Cholesterol Levels and Crystallization With Ezetimibe and Are Correlated With Fluorodeoxyglucose Positron Emission Tomography

(2011) Roshan Patel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Estrogen-dependent activation of neutral cholesterol ester hydrolase underlying gender difference of atherogenesis in apoE−/− mice

(2011) Tsuyoshi Chiba et al.   ATHEROSCLEROSIS

Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging

(2011) Ryan S. Lim et al.   JOURNAL OF LIPID RESEARCH

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Imaging the subcellular structure of human coronary atherosclerosis using micro–optical coherence tomography

(2011) Linbo Liu et al.   NATURE MEDICINE

A Prospective Natural-History Study of Coronary Atherosclerosis

(2011) Gregg W. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins

(2010) Martin Hersberger   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation

(2010) George S. Abela   Journal of Clinical Lipidology

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

TNFα in atherosclerosis, myocardial ischemia/reperfusion and heart failure

(2010) Petra Kleinbongard et al.   PHARMACOLOGY & THERAPEUTICS

Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients With Acute Coronary and Cerebrovascular Syndromes

(2009) George S. Abela et al.   AMERICAN JOURNAL OF CARDIOLOGY

ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia

(2009) Marijn C. Meuwese et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cardiovascular Manifestations in Human Immunodeficiency Virus-Infected Patients

(2008) Chotikorn Khunnawat et al.   AMERICAN JOURNAL OF CARDIOLOGY

Physical factors that trigger cholesterol crystallization leading to plaque rupture

(2008) Ameeth Vedre et al.   ATHEROSCLEROSIS

CRAC motif peptide of the HIV-1 gp41 protein thins SOPC membranes and interacts with cholesterol

(2008) Alexander I. Greenwood et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES