Article
Biochemistry & Molecular Biology
Matthew F. Waters, Viviane Delghingaro-Augusto, Kiran Javed, Jane E. Dahlstrom, Gaetan Burgio, Stefan Broer, Christopher J. Nolan
Summary: The study found that knocking out the Slc6a19 gene does not prevent or delay the development of type 1 diabetes in female NOD mice.
Article
Biochemistry & Molecular Biology
Melanie Raquel Martinez-Cignoni, Agusti Gonzalez-Vicens, Andrea Moran-Costoya, Ana Maria Proenza, Magdalena Gianotti, Adamo Valle, Isabel Llado
Summary: The study suggests that in the context of diabetes and obesity, estradiol may lose its cardioprotective role and even contribute to greater metabolic alterations. Ovariectomy attenuated the diabetic condition and metabolic dysfunction in fa/fa rats, indicating a potential negative impact of estradiol in obese-diabetic individuals. Adipose tissue from ovariectomized rats showed a healthier expansion pattern, which could help maintain tissue function and reduce inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Theun de Groot, Rosalinda Doty, Lars Damen, Ruben Baumgarten, Steffi Bressers, Joline Kraak, Peter M. T. Deen, Ron Korstanje
Summary: Chronic lithium treatment in female mice of different inbred strains led to increased urine production and/or reduced urine osmolality in 21 strains. The study found that genetic background plays an important role in the development of lithium-induced nephrogenic diabetes insipidus and chronic renal pathology. Additionally, urinary beta 2-microglobulin was identified as a promising biomarker for chronic renal damage induced by lithium.
PHYSIOLOGICAL GENOMICS
(2021)
Review
Biochemistry & Molecular Biology
Yi Chen, Yashpal S. Kanwar, Xueqin Chen, Ming Zhan
Summary: Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide. Its prevalence in the elderly is increasing due to the trend of aging. Genetic factors, abnormal glucose metabolism, inflammation, mitochondrial dysregulation, and oxidative stress all play a role in the development of DKD. These pathobiological processes are likely to be intensified during aging, exacerbating the deterioration of renal functions and leading to ESRD. The pathogenesis of DKD in the elderly is not well-understood, and this study provides an appraisal of the relationship between diabetic nephropathy and aging, discussing the changes in the aged kidney, the impact of related mechanisms, and the latest advances in targeted therapies.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Alejandro Martinez-Gayo, Elisa Felix-Soriano, Neira Sainz, Pedro Gonzalez-Muniesa, Maria J. Moreno-Aliaga
Summary: Obesity and aging promote chronic low-grade systemic inflammation. This study aimed to analyze the effects of long-term physical exercise and/or omega-3 fatty acid DHA supplementation on muscle metabolism, inflammation, muscle damage/regeneration, and myokine expression in aged and obese mice. The results showed that long-term exercise can prevent the deleterious effects of aging and obesity on muscle function.
Article
Biochemistry & Molecular Biology
Elisa Felix-Soriano, Neira Sainz, Marta Fernandez-Galilea, Eva Gil-Iturbe, Jon Celay, Jose A. Martinez-Climent, Maria J. Moreno-Aliaga
Summary: This study aimed to investigate the potential beneficial effects of chronic docosahexaenoic acid (DHA) supplementation on restoring subcutaneous white adipose tissue (scWAT) plasticity in obese aged female mice. The results showed that the DHA-enriched diet reduced adipocyte size and reversed the upregulation of lipogenic genes induced by the high fat diet (HFD). DHA supplementation restored the increase of proinflammatory genes, switched scWAT macrophages profile to a healthier phenotype, and induced beige adipocyte markers in obese aged mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Zhen Guo, Yixuan Zhang, Chang Liu, Ji Youn Youn, Hua Cai
Summary: The study demonstrates the important role of TLR2 in endothelial dysfunction and inflammatory activation in type 2 diabetes mellitus (T2DM). Deficiency of TLR2 can reduce weight gain, lower blood glucose, insulin, and leptin levels, and improve fat mass in T2DM mice. TLR2 deficiency improves physical activity, mitochondrial function, and vasorelaxation in T2DM, indicating a potential therapeutic target for obesity and cardiovascular complications associated with T2DM.
Article
Obstetrics & Gynecology
Hadas Miremberg, Hadas Ganer Herman, Mor Bustan, Eran Weiner, Letizia Schreiber, Jacob Bar, Michal Kovo
Summary: The study found that women with preeclampsia have a higher rate of MVM lesions in placental histopathology compared to men, indicating a sex-specific difference in placental pathophysiological adaptation in early preeclampsia.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Microbiology
Debra L. Walter, Jean R. Thuma, Ramiro Malgor, Frank L. Schwartz, Kelly D. McCall, Karen T. Coschigano
Summary: Despite efforts to advance American kidney health, kidney disease has risen to the 8th leading cause of death in the US. Recent studies aim to identify molecular markers for kidney injury and predict patient outcomes, revealing distinct injury profiles within kidney disease and potential causes for kidney damage.
Article
Veterinary Sciences
Sofie Kromann, Sharmin Baig, Marc Stegger, Rikke Heidemann Olsen, Anders Miki Bojesen, Henrik Elvang Jensen, Ida Thofner
Summary: This study explored the lesions causing background mortality in broiler breeders and the diversity of Escherichia coli strains. It found that exudative peritonitis was the most frequent lesion linked to infectious disease, and different genetic lineages of E. coli were present in birds without apparent infections.
VETERINARY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Eunjin Oh, Erika M. McCown, Miwon Ahn, Pablo A. Garcia, Sergio Branciamore, Shanshan Tang, De-Fu Zeng, Bart O. Roep, Debbie C. Thurmond
Summary: STX4 plays a crucial role in regulating human islet beta-cell function, with reduced expression potentially linked to type 1 diabetes. Increasing STX4 expression can improve blood glucose control and promote beta-cell survival in NOD mice.
Review
Veterinary Sciences
Lisa M. Mangus, Monique S. Franca, H. L. Shivaprasad, Jeffrey C. Wolf
Summary: Non-mammalian vertebrates, such as birds, fish, and amphibians, have been significant contributors to scientific discoveries and are popular animal models due to their experimental advantages and genetic homology with higher vertebrates. Understanding their anatomy, physiology, and diseases is crucial for animal welfare and accurate research findings.
Review
Veterinary Sciences
Kristi L. Helke, David K. Meyerholz, Amanda P. Beck, Eric R. Burrough, Rachel J. Derscheid, Christiane Lohr, Elizabeth F. McInnes, Cheryl L. Scudamore, Cory F. Brayton
Summary: Animal models are valuable tools for biomedical researchers, but careful consideration of various features and background factors is necessary for accurate interpretation of results. Different species, breeds/stocks, sex, age, diseases, and other factors can all impact study outcomes.
Article
Obstetrics & Gynecology
Filiz Halici-Ozturk, Fatma Didem Yucel Yetiskin, Beril Gurlek, Fatma Doga Ocal, Kadriye Yakut, Yaprak Engin-Ustun, Sevki Celen, Dilek Sahin
Summary: This study investigates the relationship between fetal anogenital distance (AGD) and maternal diabetes and obesity. The results show that both maternal diabetes and obesity are significantly associated with longer AGD in female fetuses. Fetal AGD may serve as a biomarker to predict reproductive system abnormalities related to prenatal androgen exposure.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Babalwa Unice Jack, Pritika Ramharack, Christiaan Malherbe, Kwazi Gabuza, Elizabeth Joubert, Carmen Pheiffer
Summary: Previous studies have shown that crude polyphenol-enriched fraction of Cyclopia intermedia (CPEF), commonly known as honeybush, can reduce lipid content in adipocytes and inhibit body weight gain in obese mice. This study further explored the mechanisms behind these effects and found that CPEF induces the expression of UCP1 and PPAR alpha in brown adipose tissue, promoting thermogenesis and fatty acid oxidation. The compounds hesperidin and neoponcirin in CPEF were found to have specific interactions with UCP1 and PPAR alpha, respectively, suggesting their potential role in the anti-obesity effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kyungmouk Steve Lee, Sara F. Santagostino, David Li, Amit Ramjit, Kenneth Serrano, Michael D. Ginsberg, Bi-Sen Ding, Shahin Rafii, David C. Madoff
Article
Dermatology
Ilaria Porcellato, Luca Luciani, Maria Luisa Marenzoni, Sara Francesca Santagostino, Monica Sforna, Luca Mechelli, Chiara Brachelente
VETERINARY DERMATOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Jonathan B. Rosenberg, Michael G. Kaplitt, Bishnu P. De, Alvin Chen, Thomas Flagiello, Christiana Salami, Eduard Pey, Lingzhi Zhao, Rodolfo J. Ricart Arbona, Sebastien Monette, Jonathan P. Dyke, Douglas J. Balion, Stephen M. Kaminsky, Dolan Sondhi, Gregory A. Petsko, Steven M. Paul, Ronald G. Crystal
HUMAN GENE THERAPY CLINICAL DEVELOPMENT
(2018)
Article
Biochemistry & Molecular Biology
Ben Roediger, Quintin Lee, Shweta Tikoo, Joanna C. A. Cobbin, James M. Henderson, Mika Jormakka, Matthew B. O'Rourke, Matthew P. Padula, Natalia Pinello, Marisa Henry, Maria Wynne, Sara F. Santagostino, Cory F. Brayton, Lorna Rasmussen, Leszek Lisowski, Szun S. Tay, David C. Harris, John F. Bertram, John P. Dowling, Patrick Bertolino, Jack H. Lai, Wengen Wu, William W. Bachovchin, Justin J-L Wong, Mark D. Gorrell, Babak Shaban, Edward C. Holmes, Christopher J. Jolly, Sebastien Monette, Wolfgang Weninger
Article
Veterinary Sciences
Melissa A. Nashat, Rodolfo J. Ricart Arbona, Michelle L. Lepherd, Sara F. Santagostino, Robert S. Livingston, Elyn R. Riedel, Neil S. Lipman
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2018)
Article
Oncology
Elise Bonvin, Enrico Radaelli, Martin Bizet, Flavie Luciani, Emilie Calonne, Pascale Putmans, David Nittner, Nitesh Kumar Singh, Sara Francesca Santagostino, Valerie Petit, Lionel Larue, Jean Christophe Marine, Francois Fuks
Editorial Material
Veterinary Sciences
Sara F. Santagostino, Lorna A. Omodho, Annick Francis, Stephanie De Vleeschauwer, Kris Meurrens, Enrico Radaelli
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2019)
Review
Veterinary Sciences
Enrico Radaelli, Sara F. Santagostino, Rani S. Sellers, Cory F. Brayton
Review
Cell Biology
Joshua D. Webster, Sara F. Santagostino, Oded Foreman
CELL AND TISSUE RESEARCH
(2020)
Article
Cell Biology
Joshua D. Webster, Youngsu C. Kwon, Summer Park, Hua Zhang, Nick Corr, Nina Ljumanovic, Adeyemi O. Adedeji, Eugene Varfolomeev, Tatiana Goncharov, Jessica Preston, Sara F. Santagostino, Snahel Patel, Min Xu, Jonathan Maher, Brent S. McKenzie, Domagoj Vucic
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Pathology
Sara Francesca Santagostino, Marco Spinazzi, Enrico Radaelli
Summary: This study evaluated the outcomes of FJ-C staining in different models of neurodegeneration, revealing that the staining is sensitive to specific conditions of neuronal cell death but may fail to detect neuronal death in certain cases. Complementary techniques are crucial for evaluating neurodegeneration in the absence of a positive FJ-C signal.
VETERINARY PATHOLOGY
(2021)
Editorial Material
Pathology
Sara Francesca Santagostino, Enrico Radaelli
VETERINARY PATHOLOGY
(2021)
Review
Pathology
Sara Francesca Santagostino, Charles-Antoine Assenmacher, James C. Tarrant, Adeyemi O. Adedeji, Enrico Radaelli
Summary: Balancing cell survival and cell death is crucial for development and homeostasis. Regulated cell death (RCD) is involved in fundamental processes such as organogenesis and tissue remodeling, and recent findings have deepened our understanding of RCD mechanisms. Further research is needed to characterize RCD and its role in disease, beyond traditional terms like apoptosis and necrosis.
VETERINARY PATHOLOGY
(2021)
Article
Pathology
Fangyao Hu, Sara F. Santagostino, Dimitry M. Danilenko, Min Tseng, Jochen Brumm, Philip Zehnder, Kai Connie Wu
Summary: Skin toxicity is a common safety concern associated with drugs, and the use of a three-dimensional reconstructed human epidermis model has shown potential for predicting and measuring skin toxicity with high accuracy and practicality.
AMERICAN JOURNAL OF PATHOLOGY
(2022)