A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia

Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current

(2015) Arie Verkerk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction

(2015) Raffaella Milanesi et al.   JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY

Autonomic Control of Heart Rate and QT Interval Variability Influences Arrhythmic Risk in Long QT Syndrome Type 1

(2015) Alberto Porta et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current

(2014) Arie O. Verkerk et al.   EUROPACE

Gene Therapy for Restoring Heart Rhythm

(2014) Gerard J. J. Boink et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Funny channel gene mutations associated with arrhythmias

(2013) Dario DiFrancesco   JOURNAL OF PHYSIOLOGY-LONDON

Surprise, Surprise

(2012) Bryan C. Cannon et al.   CIRCULATION

Altered HCN4 channel C-linker interaction is associated with familial tachycardia–bradycardia syndrome and atrial fibrillation

(2012) Nana Duhme et al.   EUROPEAN HEART JOURNAL

Ivabradine

(2012) Melvin M. Scheinman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clinical Efficacy of Ivabradine in Patients With Inappropriate Sinus Tachycardia

(2012) Riccardo Cappato et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inappropriate Sinus Tachycardia

(2012) Brian Olshansky et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes

(2012) John R. Giudicessi et al.   Translational Research

Inappropriate Sinus Tachycardia

(2011) Francisco Femenía et al.   Cardiology in Review

The funny current has a major pacemaking role in the sinus node

(2011) Dario DiFrancesco et al.   HEART RHYTHM

A Pediatric Case of Cardiomyopathy Induced by Inappropriate Sinus Tachycardia: Efficacy of Ivabradine

(2011) Emanuele Romeo et al.   PEDIATRIC CARDIOLOGY

The Role of the Funny Current in Pacemaker Activity

(2010) Dario DiFrancesco   CIRCULATION RESEARCH

Efficacy of ivabradine administration in patients affected by inappropriate sinus tachycardia

(2010) Leonardo Calò et al.   HEART RHYTHM

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

(2010) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ivabradine in patients with inappropriate sinus tachycardia

(2010) Stephan Zellerhoff et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The cardiac pacemaker current

(2009) Mirko Baruscotti et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels

(2008) Kimberley B. Craven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers

(2008) K. E. Berge et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531

(2007) Chen-Hong Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY