Cardiac endothelium–myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction

Serelaxin: A Novel Therapy for Acute Heart Failure with a Range of Hemodynamic and Non-Hemodynamic Actions

(2014) Javier Díez   American Journal of Cardiovascular Drugs

Dickkopf-3 attenuates pressure overload-induced cardiac remodelling

(2014) Yan Zhang et al.   CARDIOVASCULAR RESEARCH

Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1)

(2014) Diana Bonderman et al.   CHEST

Pulmonary Hypertension Is Related to Peripheral Endothelial Dysfunction in Heart Failure With Preserved Ejection Fraction

(2014) Marta Farrero et al.   Circulation-Heart Failure

Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study

(2014) Nicolas Amabile et al.   EUROPEAN HEART JOURNAL

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apelin Increases Cardiac Contractility via Protein Kinase Cε- and Extracellular Signal-Regulated Kinase-Dependent Mechanisms

(2014) Ábel Perjés et al.   PLoS One

Acute Intravenous Injection of Serelaxin (Recombinant Human Relaxin‐2) Causes Rapid and Sustained Bradykinin‐Mediated Vasorelaxation

(2014) Chen Huei Leo et al.   Journal of the American Heart Association

Anti‐Remodeling and Anti‐Fibrotic Effects of the Neuregulin‐1β Glial Growth Factor 2 in a Large Animal Model of Heart Failure

(2014) Cristi L. Galindo et al.   Journal of the American Heart Association

Effects of Exercise Training on Outcomes in Women With Heart Failure

(2014) Ileana L. Piña et al.   JACC-Heart Failure

An Engineered Bivalent Neuregulin Protects Against Doxorubicin-Induced Cardiotoxicity With Reduced Proneoplastic Potential

(2013) Steven M. Jay et al.   CIRCULATION

Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact

(2013) John J. V. McMurray et al.   EUROPEAN JOURNAL OF HEART FAILURE

Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

(2013) Maria Jelinic et al.   FASEB JOURNAL

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

(2013) Julie Halkein et al.   JOURNAL OF CLINICAL INVESTIGATION

Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2013) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effect of Endurance Exercise Training on Endothelial Function and Arterial Stiffness in Older Patients With Heart Failure and Preserved Ejection Fraction

(2013) Dalane W. Kitzman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relaxin Family Peptides and Their Receptors

(2013) R. A. D. Bathgate et al.   PHYSIOLOGICAL REVIEWS

Stimulating Myocardial Regeneration with Periostin Peptide in Large Mammals Improves Function Post-Myocardial Infarction but Increases Myocardial Fibrosis

(2013) Dennis Ladage et al.   PLoS One

Design of the RELAXin in Acute Heart Failure Study

(2012) Piotr Ponikowski et al.   AMERICAN HEART JOURNAL

Inhibition of Neuregulin-1/ErbB Signaling in the Rostral Ventrolateral Medulla Leads to Hypertension through Reduced Nitric Oxide Synthesis

(2012) R. Matsukawa et al.   AMERICAN JOURNAL OF HYPERTENSION

Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy

(2012) Chun Gui et al.   CARDIOVASCULAR PATHOLOGY

Relaxin improves TNF-α-induced endothelial dysfunction: the role of glucocorticoid receptor and phosphatidylinositol 3-kinase signalling

(2012) Thomas Dschietzig et al.   CARDIOVASCULAR RESEARCH

Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction

(2012) Loek van Heerebeek et al.   CIRCULATION

A contemporary view on endothelial function in heart failure

(2012) Eduard Shantsila et al.   EUROPEAN JOURNAL OF HEART FAILURE

Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload

(2012) Ella G. Frolova et al.   FASEB JOURNAL

Soluble guanylate cyclase: a potential therapeutic target for heart failure

(2012) Mihai Gheorghiade et al.   HEART FAILURE REVIEWS

Incremental Prognostic Significance of Peripheral Endothelial Dysfunction in Patients With Heart Failure With Normal Left Ventricular Ejection Fraction

(2012) Eiichi Akiyama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelial Dysfunction, Arterial Stiffness, and Heart Failure

(2012) Catherine N. Marti et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial

(2012) Scott D Solomon et al.   LANCET

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

(2012) John R Teerlink et al.   LANCET

Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice

(2011) M. S. Segal et al.   BLOOD

Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats

(2011) Bingong Li et al.   Cardiovascular Diabetology

Sildenafil and B-Type Natriuretic Peptide Acutely Phosphorylate Titin and Improve Diastolic Distensibility In Vivo

(2011) Kalkidan Bishu et al.   CIRCULATION

Endothelium-Derived Neuregulin Protects the Heart Against Ischemic Injury

(2011) Nadia Hedhli et al.   CIRCULATION

Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction

(2011) Marco Guazzi et al.   CIRCULATION

Thrombospondin-4 Is Required for Stretch-Mediated Contractility Augmentation in Cardiac Muscle

(2011) Oscar H. Cingolani et al.   CIRCULATION RESEARCH

Relaxin Induces Rapid Dilation of Rodent Small Renal and Human Subcutaneous Arteries via PI3 Kinase and Nitric Oxide

(2011) Jonathan T. McGuane et al.   ENDOCRINOLOGY

Endogenous Thrombospondin 1 Protects the Pressure-Overloaded Myocardium by Modulating Fibroblast Phenotype and Matrix Metabolism

(2011) Ying Xia et al.   HYPERTENSION

Relation of Brachial and Digital Measures of Vascular Function in the Community

(2011) Naomi M. Hamburg et al.   HYPERTENSION

Cardiac Myocyte-specific Ablation of Follistatin-like 3 Attenuates Stress-induced Myocardial Hypertrophy

(2011) Masayuki Shimano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of acute decompensated heart failure with the soluble guanylate cyclase activator cinaciguat: The COMPOSE program – three randomized, controlled, phase IIb studies

(2011) Mihai Gheorghiade et al.   JOURNAL OF CARDIAC FAILURE

Neuregulin-1/ErbB signaling in rostral ventrolateral medulla is involved in blood pressure regulation as an antihypertensive system

(2011) Ryuichi Matsukawa et al.   JOURNAL OF HYPERTENSION

Exercise Training Improves Exercise Capacity and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction

(2011) Frank Edelmann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload

(2011) M. Shimano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy

(2010) Katrien Lemmens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiorenal Syndrome

(2010) Jeremy S. Bock et al.   CIRCULATION

Cell Communications in the Heart

(2010) Daniela Tirziu et al.   CIRCULATION

Cardiac Titin

(2010) Martin M. LeWinter et al.   CIRCULATION

Exercise Training in Older Patients With Heart Failure and Preserved Ejection Fraction

(2010) Dalane W. Kitzman et al.   Circulation-Heart Failure

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses

(2010) Andrew Jabbour et al.   EUROPEAN JOURNAL OF HEART FAILURE

Epidemiology and clinical course of heart failure with preserved ejection fraction

(2010) Carolyn S.P. Lam et al.   EUROPEAN JOURNAL OF HEART FAILURE

Unveiling the Vasodilatory Actions and Mechanisms of Relaxin

(2010) Kirk P. Conrad   HYPERTENSION

Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models

(2010) Yuliya Sharkovska et al.   JOURNAL OF HYPERTENSION

A Phase II, Randomized, Double-Blind, Multicenter, Based on Standard Therapy, Placebo-Controlled Study of the Efficacy and Safety of Recombinant Human Neuregulin-1 in Patients With Chronic Heart Failure

(2010) Runlin Gao et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction

(2010) Barry A. Borlaug et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

(2009) Kevin Bersell et al.   CELL

Activin A and Follistatin-Like 3 Determine the Susceptibility of Heart to Ischemic Injury

(2009) Yuichi Oshima et al.   CIRCULATION

Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy

(2009) Melissa Swinnen et al.   CIRCULATION

Current trends in heart failure readmission rates: analysis of medicare data

(2009) Juan M. Aranda et al.   CLINICAL CARDIOLOGY

Caveat medicus! Pulmonary hypertension in the elderly: a word of caution

(2009) Barry A. Boilson et al.   EUROPEAN JOURNAL OF HEART FAILURE

Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart

(2009) Hiroyuki Masuyama et al.   HYPERTENSION RESEARCH

Efficacy and Safety of Exercise Training in Patients With Chronic Heart Failure

(2009) Christopher M. O’Connor et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

(2009) Jessie Gu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload

(2009) Anna N. Panek et al.   PLoS One

Acute hemodynamic response to single oral doses of BAY 60-4552, a soluble guanylate cyclase stimulator, in patients with biventricular heart failure

(2009) Veselin Mitrovic et al.   BMC Pharmacology & Toxicology

Cardioprotective effects in aged spontaneously hypertensive rats due to chronic stimulation/activation of sGC without hypotension

(2009) Emma S Jones et al.   BMC Pharmacology & Toxicology

Nitric Oxide, Tetrahydrobiopterin, Oxidative Stress, and Endothelial Dysfunction in Hypertension

(2008) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Connective tissue growth factor induces cardiac hypertrophy through Akt signaling

(2008) Nozomi Hayata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Follistatin-Like 1 Is an Akt-Regulated Cardioprotective Factor That Is Secreted by the Heart

(2008) Yuichi Oshima et al.   CIRCULATION

NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy

(2006) Philipp Kalk et al.   BRITISH JOURNAL OF PHARMACOLOGY