Article
Endocrinology & Metabolism
Jun-hao Zhang, Wei Li, Cheng-yue Wang, An-ni Zhang, Ben-zhong Jia, Ya-wei Li, Zhen-duo Shi, Kai-fa Tang, Cong-hui Han
Summary: The study aims to investigate the relationship between serum 25(OH)D and carotid artery intima-media thickness (CIMT) in men with erectile dysfunction (ED). Results showed that serum 25(OH)D levels were significantly decreased in ED patients compared to the healthy control group, while CIMT values were significantly increased in the moderate and severe ED groups compared to the control group. IIEF-5 score was positively correlated with serum 25(OH)D level and negatively correlated with CIMT value. After adjusting for confounding factors, there were significant associations between CIMT values, 25(OH)D levels, and IIEF-5 scores.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Aashir Kaul, Arun Kumar, Aditya Baksi, Vitish Singla, Sandeep Aggarwal, Gurpreet Gulati, Rajiv Narang, Lokesh Kashyap
Summary: This study demonstrates that bariatric surgery can significantly reduce CIMT and CVD risk in patients with morbid obesity. Additionally, it also shows positive improvements in lipid profile, fasting blood sugar, and HbA(1C) levels.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Biochemistry & Molecular Biology
Elena V. Gerasimova, Tatiana V. Popkova, Daria A. Gerasimova, Yuliya V. Markina, Tatiana V. Kirichenko
Summary: This study aimed to evaluate the rate of subclinical carotid atherosclerosis and the clinical significance of immunoinflammatory markers in rheumatoid arthritis (RA) patients. The results showed a higher occurrence of subclinical carotid atherosclerosis in RA patients compared to the control group. There was no correlation between serum markers and subclinical carotid atherosclerosis in RA patients. The study revealed the association between cIMT, traditional cardiovascular risk factors, and immunoinflammatory markers in RA patients.
Article
Peripheral Vascular Disease
Maria del Mar Vila, Beatriz Remeseiro, Laura Igual, Roberto Elosua, Rafel Ramos, Jose Manuel Valdivielso, Ruth Marti-Lluch, Jaume Marrugat, Maria Grau
Summary: In men, autoimmune diseases were associated with increased common carotid intima-media thickness and higher percentage of individuals with thicker IMT. However, no significant differences were observed in arterial stiffness. Women, on the other hand, did not show significant differences in any of the carotid features between those with and without autoimmune diseases. Sex was found to be an effect modifier in the association between common carotid IMT values and autoimmune diseases diagnosis.
HYPERTENSION RESEARCH
(2021)
Article
Environmental Sciences
Pei-Lun Chu, Chien-Yu Lin, Fung-Chang Sung, Ta-Chen Su
Summary: The study found that BPA exposure is associated with atherosclerotic cardiovascular diseases, and higher levels of BPA are significantly correlated with increased levels of endothelial and platelet microparticles, as well as thicker carotid artery intima-media thickness.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cardiac & Cardiovascular Systems
Karri Parkkila, Antti Kiviniemi, Mikko Tulppo, Juha Perkiomaki, Y. Antero Kesaniemi, Olavi Ukkola
Summary: In a prospective study with over 20 years of follow-up, the length of plaques in abdominal-pelvic main arteries (SUM) was found to be a superior indicator for evaluating overall cardiovascular risk compared to carotid intima-media thickness (IMT). SUM significantly predicted CV events and improved the discrimination and reclassification of patients when added to the established model, while IMT only predicted cardiovascular events in univariate analysis and did not improve discrimination or reclassification.
Article
Peripheral Vascular Disease
Xiaoxiang Ma, Yue Zhuo, Yu Huang, Pengming He, Zhaoyi Huang, Li Jiang, Luyao Tong, Xiaoqin Yao, Xueping Wen, Xuemei Zhong, Shihan Yang, Changqiong Li, Yuping Liu, Zhixin Zhang
Summary: This study reveals that abnormal T-cell responses may play important roles in the progression of essential hypertension and its subclinical target organ damage. The TCR beta repertoires of patients with essential hypertension are significantly different, and are correlated with carotid plaque formation.
Article
Pharmacology & Pharmacy
Pinar Diydem Yilmaz, Cengiz Kadiyoran, Mevlut Hakan Goktepe, Yasemin Akkubak, Abdullah Icli, Adem Kucuk
Summary: S1 levels may rise in AS patients to suppress the inverse effects of proinflammatory cytokines and inflammation. Our study found a negative relationship between cIMT values of AS patients and S1 levels, indicating a protective effect of S1 on the development of atherosclerosis in AS patients.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Gastroenterology & Hepatology
Mar Riveiro-Barciela, Cristina Marcos-Fosch, Fernando Martinez-Valle, Fabrizio Bronte, Olimpia Orozco, Isidro Sanz-Perez, Daniele Torres, Maria-Teresa Salcedo, Salvatore Petta, Rafael Esteban, Antonio Craxi, Maria Buti
Summary: Untreated HBeAg-negative CHB is an independent risk factor for carotid plaques and subclinical atherosclerosis, while ICs present a similar risk to controls.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Javier Donate-Correa, Carla M. Ferri, Ernesto Martin-Nunez, Nayra Perez-Delgado, Ainhoa Gonzalez-Luis, Carmen Mora-Fernandez, Juan F. Navarro-Gonzalez
Summary: The study demonstrates an association between decreased levels of Klotho protein and subclinical atherosclerosis in patients with chronic kidney disease (CKD). Both serum and peripheral blood cells (PBCs) expression levels of Klotho were found to be significantly lower in patients with subclinical atherosclerosis, and were independent determinants for arterial stiffness markers. This suggests that maintaining or elevating Klotho levels may have potential therapeutic benefits in reducing cardiovascular disease risk in CKD patients.
SCIENTIFIC REPORTS
(2021)
Review
Obstetrics & Gynecology
Joanne Michelle D. Gomez, Katherine VanHise, Nina Stachenfeld, Jessica L. Chan, Noel Bairey Merz, Chrisandra Shufelt
Summary: Polycystic ovary syndrome (PCOS) affects approximately 6%-10% of women worldwide, with features of hyperandrogenism, irregular menses, infertility, and polycystic appearing ovaries on ultrasound. PCOS is also associated with endocrine and metabolic disorders that increase the risk for subclinical cardiovascular disease.
FERTILITY AND STERILITY
(2022)
Article
Cardiac & Cardiovascular Systems
Evangelos Oikonomou, George Lazaros, Vasiliki Chara Mystakidi, Nikolaos Papaioannou, Panagiotis Theofilis, Georgia Vogiatzi, Christos Chasikidis, Petros Fountoulakis, Maria-Argentina Papakostantinou, Margarita Niki Assimakopoulos, Nikolaos Barmparesos, Panagiotis Tasios, Juan C. Kaski, Dimitris Tousoulis
Summary: The study demonstrates that residents in areas with high concentrations of gaseous air pollutants have increased carotid atherosclerotic burden and inflammation compared to residents in other regions. High levels of CO, NO2, and SO2 were observed in Region 4, where individuals also showed higher levels of C reactive protein and greater carotid plaque burden. Additionally, the propensity score analysis indicated higher differences in mean cIMT among individuals with coronary artery disease in high pollution areas compared to low pollution areas.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Clara Costo-Muriel, Julian F. Calderon-Garcia, Sergio Rico-Martin, Javier Galan-Gonzalez, Guillermo Escudero-Sanchez, Carmen Sanchez-Bacaicoa, Francisco J. Rodriguez-Velasco, Esperanza Santano-Mogena, Cesar Fonseca, Juan F. Sanchez Munoz-Torrero
Summary: In recent years, new anthropometric indices have been developed as alternatives to BMI and other traditional measurements to enhance the estimation of fat proportion and its relationship to future cardiovascular events. This study investigated the association between carotid intima-media thickness (c-IMT) estimated by Doppler ultrasound and current anthropometric indices. The study found that ABSI, CI, and WWI were positively associated with pathological c-IMT, independent of other confounders.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Jose Luis Perez-Lasierra, Jose A. Casajus, Alejandro Gonzalez-Aguero, Jose Miguel Arbones-Mainar, Jose A. Casasnovas, Martin Laclaustra, Belen Moreno-Franco
Summary: This study analyzed the association between the APOE e4 genetic variant and carotid atherosclerosis, as well as the association between cardiorespiratory fitness (CRF) and atherosclerosis in individuals with the APOE e4 genetic variant. The findings showed that the APOE e4e4 genotype was associated with increased carotid atherosclerosis, while CRF was a modifiable factor that could be targeted to decrease the atherosclerotic risk in individuals with the APOE e4e4 genetic variant.
SCIENTIFIC REPORTS
(2022)
Article
Peripheral Vascular Disease
Maryam Zaid, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Sayaka Kadowaki, Atsushi Satoh, Akira Sekikawa, Emma Barinas-Mitchell, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
Summary: This study aimed to investigate and compare the relationships between five different measures of carotid intima-media thickness (cIMT) and coronary calcium. The results showed that Mean-Max cIMT had consistently stronger associations with coronary calcium, independent of important confounders such as age. The commonly used measure, CCA(mean), was no longer associated with coronary calcium after age-adjustment and stratification.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Oncology
Anshul Saxena, Muni Rubens, Venkataraghavan Ramamoorthy, Zhenwei Zhang, Md Ashfaq Ahmed, Peter McGranaghan, Sankalp Das, Emir Veledar
Summary: Phase I cancer trials play a crucial role in testing the safety and optimal dosage of new cancer drugs. Understanding biostatistical methodologies is essential for developing phase I studies that are safe and effective. This review article provides an overview of important phase I study designs and aims to help researchers better understand existing methods. Adaptive designs have shown significant advantages, and ongoing studies are continuously improving and developing new methods. This study provides a concise summary of dosage selection techniques for phase I cancer trials and presents various statistical designs.
Article
Environmental Sciences
Arturo J. Barahona, Zoran Bursac, Emir Veledar, Roberto Lucchini, Kim Tieu, Jason R. Richardson
Summary: Increased blood and urinary manganese levels are associated with poorer cognitive function in an elderly US population.
Article
Multidisciplinary Sciences
Amanda Maisel-Campbell, Daniel Schlessinger, Arianna F. Yanes, Emir Veledar, Kelly A. Reynolds, Sarah A. Ibrahim, Bianca Y. Kang, Noor Anvery, Emily Poon, Murad Alam
Summary: This study aims to investigate the relationship between individual votes and Panel recommendations in the premarket review process of medical devices. It found that non-physicians, non-biostatisticians, experienced Panelists, and more talkative members are likely to vote against the majority. The presence of biostatisticians on Panels increases voting consensus. Having a diversity of opinions, including those likely to dissent from majority views, helps ensure diverse perspectives are considered before decision-making.
Article
Oncology
Muni Rubens, Adrian Cristian, Venkataraghavan Ramamoorthy, Anshul Saxena, Peter McGranaghan, Raees Tonse, Emir Veledar
Summary: Frailty is associated with adverse hospital outcomes in cancer patients, including increased length of stay, mortality, and hospitalization cost. This finding is valuable for risk stratification of cancer patients based on frailty and optimizing cancer management strategies.
JOURNAL OF GERIATRIC ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Juan Carlos Zevallos, Juan Gabriel Ruiz-Pelaez, Md Ashfaq Ahmed, Zhenwei Zhang, Peter McGranaghan, Emir Veledar, Javier Jimenez, Sandra Chaparro
Summary: Myocarditis is significantly associated with higher in-hospital mortality and adverse hospital outcomes among patients with COVID-19. The rate of in-hospital mortality is higher in COVID-19 hospitalizations with myocarditis, and the survival rate is lower. Myocarditis is also significantly associated with increased odds of cardiac arrest, cardiogenic shock, mechanical ventilation, and acute respiratory distress syndrome. Early suspicion of myocarditis is important for prompt diagnosis and management.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ramez Morcos, Haider Al Taii, Muni Rubens, Anshul Saxena, Venkataraghavan Ramamoorthy, Mohamed Hamed, Amr F. Barakat, Nitin Kulkarni, Houman Khalili, Santiago Garcia, Michael Megaly, Emir Veledar, Stavros Stavrakis
Summary: This study compared the in hospital outcomes of patients receiving catheter ablation (CA), left atrial appendage closure (LAAC), and combination of both treatments on the same day. The results showed that there were no significant differences in major adverse cardiovascular and cerebrovascular events (MACCE) between CA and combination treatment, as well as between LAAC and combination treatment.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Oncology
Muni Rubens, Anshul Saxena, Venkataraghavan Ramamoorthy, Md Ashfaq Ahmed, Zhenwei Zhang, Peter McGranaghan, Emir Veledar, Michael McDermott
Summary: This study examined the impact of COVID-19 on hospitalizations for intracranial meningioma resection using a large database. The results showed that even though hospitalization rates slightly decreased during the pandemic, hospital outcomes were not adversely affected. This highlights the importance of adequate planning and preparation to maintain quality care during healthcare emergencies.
Article
Surgery
Md Ashfaq Ahmed, Zhenwei Zhang, Venkataraghavan Ramamoorthy, Anshul Saxena, Muni Rubens, Sandeep Appunni, Peter McGranaghan, Ahmed Hasnain Jalal, Emir Veledar
Summary: This study compared the 30-day readmission rates of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) using a national dataset. The study found that the readmission rates were significantly higher in the LRYGB group compared to the LSG group. Factors such as age, chronic obstructive pulmonary disease, hypertension, bleeding disorders, blood urea nitrogen, SGOT, alkaline phosphatase, hematocrit, and operation time were found to predict readmission rates.
Article
Clinical Neurology
Ehimen C. Aneni, Chukwuemeka U. Osondu, Jeffrin Joseph, Guljana Saeed, Javier Valero-Elizondo, Emir Veledar, Khurram Nasir
Summary: This study reveals the relationship between habitual sleep duration, cardiovascular health (CVH), and their impact on healthcare costs and resource utilization. It shows that individuals with 6-8.9 hours and >= 9 hours of sleep are more likely to achieve optimal goals for diet, physical activity, body mass index, and blood pressure. Compared to those who sleep less than 6 hours, individuals with 6-8.9 hours and >= 9 hours of sleep have lower cardiovascular health risks. Furthermore, individuals with 6 or more hours of sleep have lower healthcare expenditures and reduced likelihood of emergency room visits and hospitalizations.
Meeting Abstract
Cardiac & Cardiovascular Systems
Sandeep Appunni, Venkataraghavan Ramamoorthy, Md Ashfaq Ahmed, Zhenwei Zhang, Peter McGranaghan, Ramez Morcos, Joseph Salami, Muni Rubens, Anshul Saxena, Emir Veledar, Sandra Chaparro, Javier Jimenez
Meeting Abstract
Cardiac & Cardiovascular Systems
Sandeep Appunni, Venkataraghavan Ramamoorthy, Zhenwei Zhang, Md Ashfaq Ahmed, Peter McGranaghan, Joseph Salami, Ramez Morcos, Muni Rubens, Anshul Saxena, Emir Veledar, Javier Jimenez, Sandra Chaparro
Meeting Abstract
Cardiac & Cardiovascular Systems
Mohamed Hamed, Ramez Morcos, Muni Rubens, Anshul Saxena, Emad Samaan, Mohamed Abdelazeem, Omar Hegazy, Beshoy Elkatcha, Daniel Jacobs, Brian Blair, Emir Veledar, Brijeshwar Singh Maini, Houman Khalili
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mohamed Hamed, Ramez Morcos, Muni Rubens, Anshul Saxena, Emad Samaan, Omar Hegazy, Mohamed Abdelazeem, Beshoy Elkatcha, Brian Blair, Daniel Jacobs, Brijeshwar Singh Maini, Emir Veledar, Houman Khalili
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Ethics
Charlotte McDaniel, Emir Veledar
Summary: This study examined ethics perceptions among long-term care employees, revealing significant differences based on racial-ethnic and work positions, as well as confirming strong relationships between ethics and employees' work features. The findings suggest potential avenues for addressing disparities at work and enhancing the quality of long-term care.
Article
Endocrinology & Metabolism
Adriana G. Ioachimescu, Neevedita Goswami, Talin Handa, Adlai Pappy, Emir Veledar, Nelson M. Oyesiku
Summary: Disparities in racial distribution, clinical, and biochemical characteristics in acromegaly suggest potential late or missed diagnoses in Black patients.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
