Review
Immunology
Xi Zhang, Tianhui He, Yuan Li, Ling Chen, Hongyu Liu, Yu Wu, Hongyan Guo
Summary: Ovarian cancer is characterized by uncertain presentation and poor outcomes, with surgery and chemotherapy being the current basis of treatment. However, there are limitations due to advanced stage at diagnosis and high recurrence rate. The use of anti-VEGF agents, PARP inhibitors, and immunotherapies are being explored to enhance treatment outcomes, but the population that can benefit from these treatments remains limited.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Vilde Drageset Haakensen, Anna K. Nowak, Espen Basmo Ellingsen, Saima Jamil Farooqi, Maria Moksnes Bjaanaes, Henrik Horndalsveen, Tine Mcculloch, Oscar Grundberg, Susana M. Cedres, Aslaug Helland
Summary: The NIPU study is a phase II clinical trial aiming to compare the efficacy and safety of nivolumab and ipilimumab with or without telomerase vaccine in patients with inoperable malignant pleural mesothelioma after first-line platinum-based chemotherapy. The study seeks to improve treatment response by combining checkpoint inhibition with a telomerase vaccine and also to explore mechanisms for treatment response and resistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Morgan E. Janes, Alexander P. Gottlieb, Kyung Soo Park, Zongmin Zhao, Samir Mitragotri
Summary: Vaccines are important tools in immunotherapy for cancer treatment. This article provides an update on the clinical status of cancer vaccines, including analyses of 360 ongoing trials and the introduction of eight globally approved products. The article also discusses current limitations and future applications for clinical translation of cancer vaccines.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Chunxia Ge, Xuelian Yang, Jiaxuan Xin, Xiangqian Gong, Xuhan Wang, Lijun Kong
Summary: This review summarizes the use of dendritic cell (DC) vaccines as a new immunotherapy approach to enhance the body's identification and clearance of tumors by combining tumor antigens and DCs. The authors focus on discussing the biological characteristics of DCs, recent advances in understanding the antitumor mechanisms, and the classification of DC vaccines. The current progress of DC-based vaccine immunotherapy for common tumors with high morbidity or mortality in China is systematically summarized.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Cell Biology
Lily Chan, Yeganeh Mehrani, Geoffrey A. A. Wood, Byram W. W. Bridle, Khalil Karimi
Summary: DC-based cancer vaccines can recruit neutrophils to lymph nodes and increase the number of NK cells, enhancing anti-tumor immune responses. Depletion of neutrophils results in decreased NK cell numbers, while CD8+ T cell population remains unaffected. Targeting neutrophils may offer innovative strategies to enhance the clinical efficacy of DC vaccines.
Review
Immunology
Espen Basmo Ellingsen, Sara M. Mangsbo, Eivind Hovig, Gustav Gaudernack
Summary: Telomerase-based therapeutic cancer vaccines have shown potential in clinical research and may enhance the efficacy of checkpoint inhibition. With its almost universal presence in cancer and essential role in tumor growth, telomerase is an attractive therapeutic target. Rational treatment combinations, such as checkpoint inhibitors, are likely necessary to fully unlock the clinical potential of telomerase-based cancer vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Tomohiro Enokida, Alvaro Moreira, Nina Bhardwaj
Summary: Preventive cancer vaccines have shown promising results in targeting oncogenic viruses, such as HPV and HBV, but face challenges in eliminating established cancer. Ongoing research is also focusing on nonviral antigens to develop effective cancer-preventive vaccines.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Immunology
Timothy N. J. Bullock
Summary: Advances in checkpoint blockade immunotherapies have led to an expansion in methods for promoting T cell access to the tumor microenvironment, with dendritic cells playing a crucial role in the immune response to tumor antigens. The role of CD40 as a master regulator of dendritic cell activation in cancer vaccines and other immune-oncology approaches is highlighted and evaluated.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Oncology
Mehrshad Ebrahim Pour, Samin Ghorbani Moghadam, Parian Shirkhani, Amirhossein Sahebkar, Fatemeh Mosaffa
Summary: Cell-based vaccines show promise as a potential therapeutic approach for GBM, with favorable safety profiles and modest improvements in patient survival. However, further advancements are needed to overcome limitations, such as the development of potent antigens and optimization of dosage regimens.
Article
Multidisciplinary Sciences
Jie Wang, Yi Wang, Shenglin Qiao, Muhetaerjiang Mamuti, Hongwei An, Hao Wang
Summary: A new strategy is proposed in this study to improve the delivery of cancer vaccines by dynamic size modulation, enhancing lymph node drainage and dendritic cell uptake. The results showed that this strategy induced a rapid and robust immune response in a mouse model, with a stronger humoral immune response observed when immunized with MHC-II restricted antigen.
NATIONAL SCIENCE REVIEW
(2022)
Article
Oncology
Yue Liu, Joanna Pagacz, Donald J. Wolfgeher, Kenneth D. Bromerg, Jacob Gorman, Stephen J. Kron
Summary: Antigen presentation may be the limiting factor in the low immune response to radiation therapy, and combining immune checkpoint blockade does not restore cytotoxic T lymphocytes function. Therapeutic vaccines based on senescent tumor cells or SnC-activated dendritic cells have the potential to enhance immune therapies and limit recurrence or metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Alexander J. Stephens, Nicola A. Burgess-Brown, Shisong Jiang
Summary: Peptide-based cancer vaccines rely on strong activation of adaptive immune response but have not yet proven to be effective in clinical settings. To overcome limitations, vaccine designs are becoming more personalized and combined with existing cancer treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Carson R. Reynolds, Son Tran, Mohit Jain, Aru Narendran
Summary: Neoantigen-based immunotherapeutic approaches have become an effective and highly tolerable therapeutic option in the rapidly evolving field of cancer treatment.
Article
Immunology
Valentina Ceglia, Sandra Zurawski, Monica Montes, Mitchell Kroll, Aurelie Bouteau, Zhiqing Wang, Jerome Ellis, Botond Z. Igyarto, Yves Levy, Gerard Zurawski
Summary: CD40 is an activating receptor that regulates B and T cell immunity. Fusing CD40L to anti-CD40 antibodies enhances the agonistic activity and immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Jing Zhou, Luohong Li, Minqi Jia, Qianjin Liao, Guiping Peng, Gengqiu Luo, Yanhong Zhou
Summary: This paper discusses the reasons for the dysfunction of DCs in the tumor microenvironment, analyzes the impact of DC vaccines on improving the immunosuppressive microenvironment in glioma patients, and proposes new development directions and challenges for DC vaccines.
Article
Biochemical Research Methods
Jyotsna Kailashiya
ANALYTICAL BIOCHEMISTRY
(2018)
Article
Sport Sciences
Hanjabam B. Sharma, Jyotsna Kailashiya
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2018)
Article
Immunology
Vikas Kailashiya, Usha Singh, Ranjan Rana, Nand Kumar Singh, Debabrata Dash, Jyotsna Kailashiya
IMMUNOLOGICAL INVESTIGATIONS
(2019)
Article
Pathology
Vikas Kailashiya, Hanjabam Barun Sharma, Jyotsna Kailashiya
JOURNAL OF CLINICAL PATHOLOGY
(2019)
Letter
Anesthesiology
Ankur Khandelwal, Indu Kapoor, Charu Mahajan, Hanjabam Barun Sharma, Hemanshu Prabhakar
JOURNAL OF CLINICAL ANESTHESIA
(2020)
Article
Chemistry, Physical
S. K. Shaw, J. Kailashiya, A. Gangwar, S. K. Alla, Santosh K. Gupta, C. L. Prajapat, Sher Singh Meena, D. Dash, P. Maiti, N. K. Prasad
Summary: Recent research has uncovered a method of preparing gamma-Fe2O3 nanoflowers using microwave-assisted polyol technique with varying amounts of sodium acetate to modify structural and magnetic properties, leading to high efficiency heating performance during MHT and PTT.
APPLIED SURFACE SCIENCE
(2021)
Article
Orthopedics
Ankur Khandelwal, Arvind Chaturvedi, Navdeep Sokhal, Akanksha Singh, Hanjabam Barun Sharma
Summary: This study compared the effects of propofol and ketofol on TcMEP amplitudes and latencies during thoracolumbar spine surgery. The results showed that ketofol increased TcMEP amplitudes and had a better and more stable hemodynamic profile compared to propofol.
ASIAN SPINE JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Jyotsna Kailashiya, Debabrata Dash
Summary: This study found that nanoceria particles have effects on human platelet function and blood coagulation, including reducing platelet aggregation and secretion of granule contents, as well as impairing fibrin polymerization and thrombus retraction. Furthermore, nanoceria may cause early clot formation in whole blood. These findings highlight the need for re-evaluation and careful planning of biomedical applications of nanoceria.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Physical
S. K. Shaw, J. Kailashiya, Santosh K. Gupta, C. L. Prajapat, Sher Singh Meena, D. Dash, P. Maiti, N. K. Prasad
Summary: Magnetic nanoparticles (MNPs) have shown great potential in thermo-therapeutic modalities such as magnetic fluid hyperthermia (MFH) and photo-thermal therapy (PTT). In this study, MnFe2O4 nano-flowers were synthesized and utilized as nano-heat generators for MFH and PTT. The material exhibited effective heating under alternating magnetic field (AMF) and impressive heating ability under near infra-red (NIR) irradiation. The results indicated that MnFe2O4 nano-flowers had higher intrinsic loss power compared to commercially available ferro-fluids and showed significant cell death during photo-thermal treatment.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Cell Biology
Deepa Gautam, Jyotsna Kailashiya, Arundhati Tiwari, Rameshwar Nath Chaurasia, Gowtham K. Annarapu, Prasenjit Guchhait, Debabrata Dash
Summary: This study reveals a novel interaction between PrP(106-126) and fibrinogen, which can mitigate neurodegeneration and enhance thrombus stability. The findings suggest that this interaction can be clinically exploited for the prevention and management of prion-related disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
S. K. Shaw, A. Sharma, J. Kailashiya, Santosh K. Gupta, Sher Singh Meena, D. Dash, P. Maiti, N. K. Prasad
Summary: In this study, mesoporous Fe3O4 MNPs were synthesized using the solvothermal process. The use of a specific solvent was found to stabilize the mesoporous structure. Structural features of the sample were studied using transmission electron microscopy (TEM) and high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM). The material showed effective heating under an alternating magnetic field (AMF), with the concentration of aqueous ferro-fluid influencing the heating performance. The material also demonstrated impressive heating performance under near infra-red (NIR) irradiation, with a concentration as small as 0.1 mg/mL.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Article
Orthopedics
Ankur Khandelwal, Arvind Chaturvedi, Navdeep Sokhal, Akanksha Singh, Hanjabam Barun Sharma
Summary: This study aimed to compare the effects of propofol and ketofol on TcMEP amplitudes and latencies during thoracolumbar spine surgery and to compare the intraoperative hemodynamics and muscle power. The results showed that ketofol increased TcMEP amplitudes without affecting latencies and had a better and more stable hemodynamic profile compared to propofol.
ASIAN SPINE JOURNAL
(2022)
Meeting Abstract
Respiratory System
Eva Eva, Ritesh Netam, Anjana Talwar, Anant Mohan, Raj Kumar Yadav, Saurabh Mittal, Hanjabam Barun Sharma, Sanjay Patel
EUROPEAN RESPIRATORY JOURNAL
(2018)
Meeting Abstract
Oncology
J. Kailashiya
