Article
Immunology
Ntungufhadzeni M. Rathogwa, Katherine A. Scott, Pamela Opperman, Jacques Theron, Francois F. Maree
Summary: This study compared the efficacy of two adjuvant formulations combined with a structurally stabilized SAT2 vaccine antigen and found that the Montanide ISA 206B-adjuvanted vaccine elicited a higher SAT2 neutralizing antibody response and three times higher systemic IFN-gamma responses compared to the Quil-A Saponin-adjuvanted vaccine group at 14- and 28-days post-vaccination. Serum antibodies from the immunized animals reacted similarly to both the parental vaccine virus and mutated viruses simulating antigenic drift in nature.
Review
Virology
Qian Li, Ashenafi Kiros Wubshet, Yang Wang, Livio Heath, Jie Zhang
Summary: The failure of cross-protection among different serotypes of foot-and-mouth disease virus poses a significant threat to endemic countries. To address this, the development of a multi-epitope vaccine is considered a promising approach. In this review, we compile relevant bioinformatic reports on B and T cell epitopes of the SAT2 serotype of FMDV, as well as experimental demonstrations of vaccines designed against this serotype.
Article
Veterinary Sciences
Yazeed A. Raouf, Inas Ibrahim
Summary: This study evaluated the impact of different genotypes of SAT2 foot-and-mouth disease virus on diagnosis and control in Sudan. The findings suggest that a monovalent vaccine is not effective in controlling the infection, and it is necessary to stockpile antigens from different genotypes and enhance virological surveillance.
VETERINARY RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Ah-Young Kim, Hyejin Kim, Sun Young Park, Sang Hyun Park, Jae-Seok Kim, Jung-Won Park, Jong-Hyeon Park, Young-Joon Ko
Summary: The optimal stabilizer composition for long-term storage of FMD vaccine antigens, especially the O JC strain, was determined, extending shelf-life at both 4 degrees C and -70 degrees C.
Article
Virology
Ayah M. Hassan, Fouad S. El-mayet, Ayman S. El-Habbaa, Momtaz A. Shahein, Mohamed M. E. El Zowalaty, M. Naglaa Hagag, Saad S. A. Sharawi
Summary: This study analyzed the ORF genome sequence of the Egyptian SAT 2/Lib-12 lineage of FMDV, providing important insights for molecular analysis and vaccine selection.
Article
Immunology
Victoria Primavera, Janine Simmons, Benjamin A. Clark, John G. Neilan, Michael Puckette
Summary: The inclusion of 2B into FMD molecular vaccine constructs enhanced transgene expression when a wildtype 3C protease is present but was detrimental to transgene expression with the 3C(L127P) mutant. This has implications for future molecular FMD vaccine constructs, which may utilize mutant FMDV 3C proteases.
Article
Virology
Rachel M. Palinski, Barbara Brito, Frederick R. Jaya, Abraham Sangula, Francis Gakuya, Miranda R. Bertram, Steven J. Pauszek, Ethan J. Hartwig, George R. Smoliga, Vincent Obanda, George P. Omondi, Kimberly VanderWaal, Jonathan Arzt
Summary: This study characterizes the genetic diversity of foot-and-mouth disease virus (FMDV) in naturally infected African buffalo, highlighting the importance of within-host evolution through recombination and point mutation in contributing to widespread viral diversity in the wildlife reservoir. These mechanisms play a critical role in FMDV persistence at the individual animal and population levels, and may contribute to the emergence of new viruses that can infect livestock and other wildlife species.
Article
Microbiology
Zhidong Zhang, Ryan Waters, Yanmin Li
Summary: Foot-and-mouth disease virus (FMDV) infection causes epithelial cell lesions and muscle-associated lesions in cloven-hoofed animals, leading to high mortality. Current knowledge about the non-epithelial tropism of FMDV remains limited.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Jonathan Arzt, Ian H. Fish, Miranda R. Bertram, George R. Smoliga, Ethan J. Hartwig, Steven J. Pauszek, Lauren Holinka-Patterson, Fayna C. Diaz-San Segundo, Tatjana Sitt, Elizabeth Rieder, Carolina Stenfeldt
Summary: Research showed that cattle can be simultaneously infected with two different serotypes of foot-and-mouth disease virus (FMDV), with different outcomes depending on the timing of exposure to the viruses. Dominant interserotypic recombinant FMDVs were discovered in upper respiratory tract samples of superinfected animals, indicating the potential role of persistently infected FMDV carriers in generating novel viral strains.
JOURNAL OF VIROLOGY
(2021)
Article
Veterinary Sciences
Taeyo Chestley, Patrycja Sroga, Michelle Nebroski, Kate Hole, Hussaini Ularamu, Oliver Lung, Charles Nfon
Summary: In this study, the Neptune bioinformatics tool was used to identify genetic signatures specific to each Southern African Territories (SAT) 1, 2 and 3 genomes but exclusionary to the other circulating FMDV serotypes. The design of TaqMan-based real-time reverse transcriptase PCR (rRT-PCR) primer/probe sets for SAT1, SAT2 and SAT3 viruses using these unique genomic regions allowed for the potential detection and differentiation of circulating FMD SAT viruses.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Infectious Diseases
Carolina Stenfeldt, Miranda R. Bertram, Haillie C. Meek, Ethan J. Hartwig, George R. Smoliga, Megan C. Niederwerder, Diego G. Diel, Scott A. Dee, Jonathan Arzt
Summary: The study investigated the infectivity of foot-and-mouth disease virus (FMDV) in commercial pig feed and feed ingredients, determining the minimum infectious dose required for pigs to develop the disease. The results indicated that FMDV can remain infectious in pig feed ingredients for durations compatible with transoceanic transport, with variations in feeding conditions and virus strains affecting the probability of infection. This information can be used to model the risk of FMDV incursions and regulate feed importation to minimize the risk of unintentional importation.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Xuan Lin, Yanli Yang, Yanmin Song, Shuai Li, Xuan Zhang, Zhiguo Su, Songping Zhang
Summary: Coordination of transition metal ions with histidine residues in FMDV capsids enhances virus stability and antibody responses, providing a guideline for large-scale production of FMDV vaccine antigen.
JOURNAL OF VIROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Huildore Bommanna Ranjitha, Valiya Valappil Dhanesh, Madhusudan Hosamani, B. P. Sreenivasa, Uzma Jabeen, Jitendra Kumar Biswal, P. Saravanan, Aniket Sanyal, Veerakyathappa Bhanuprakash, Suresh H. Basagoudanavar
Summary: Foot-and-mouth disease (FMD) is a contagious viral disease that affects cloven-hoofed animals. Preventive vaccination using inactivated virus is common practice, but the presence of antibodies to non-structural proteins is needed for differentiation of infected from vaccinated animals (DIVA). To address this, a thermostable and negative marker vaccine strain for FMDV serotype O was developed, along with a cELISA for detecting the deleted 3A region, to enhance FMD control in enzootic countries.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tatsuya Nishi, Katsuhiko Fukai, Kentaro Masujin, Rie Kawaguchi, Mitsutaka Ikezawa, Manabu Yamada, Nozomi Nakajima, Takashi Komeno, Yousuke Furuta, Hiromi Sugihara, Chie Kurosaki, Kenichi Sakamoto, Kazuki Morioka
Summary: This study found that the pyrazinecarboxamide derivative T-1105 has strong antiviral activity against foot-and-mouth disease virus (FMDV) and can effectively control the spread of FMDV in pigs.
ANTIVIRAL RESEARCH
(2022)
Article
Immunology
Kay Childs, Yongjie Harvey, Ryan Waters, Timothy Woma, Ginette Wilsden, Hualu Sun, Peng Sun, Julian Seago
Summary: Foot-and-mouth disease is a highly contagious viral disease of livestock that has a severe economic impact on the agriculture industry in many regions. Current vaccines are not effective against the contemporary strains of the disease, particularly in East Africa. Researchers have identified stable strains of the virus and developed a quadrivalent vaccine that generates high neutralizing antibody titers and provides good cross-protection against regional strains.
Article
Agriculture, Dairy & Animal Science
Juan Manuel Sala, Myrian Vanesa Trotta, Florencia Celeste Mansilla, Mariano Perez-Filgueira, Sergio Gaston Caspe, Alejandra Victoria Capozzo
JOURNAL OF APPLIED ANIMAL RESEARCH
(2018)
Article
Virology
Florencia Barrionuevo, Sebastian Di Giacomo, Danilo Bucafusco, Andrea Ayude, Juan Schammas, M. Cruz Miraglia, Alejandra Capozzo, Manuel V. Borca, Mariano Perez-Filgueira
Article
Veterinary Sciences
D. D. Lazarus, O. L. van Schalkwyk, R. E. J. Burroughs, A. Mpehle, B. Reininghaus, O. Rikhotso, L. Heath, F. F. Maree, B. Blignaut, G. T. Fosgate
PREVENTIVE VETERINARY MEDICINE
(2018)
Article
Multidisciplinary Sciences
Abhay Kotecha, Eva Perez-Martin, Yongjie Harvey, Fuquan Zhang, Serban L. Ilca, Elizabeth E. Fry, Ben Jackson, Francois Maree, Katherine Scott, Corey W. Hecksel, Michiel M. Harmsen, Valerie Mioulet, Britta Wood, Nick Juleff, David I. Stuart, Bryan Charleston, Julian Seago
SCIENTIFIC REPORTS
(2018)
Article
Agriculture, Dairy & Animal Science
Juan Pablo Jaworski, Juan Manuel Sala, Alejandra Capozzo
JOURNAL OF DAIRY SCIENCE
(2018)
Article
Immunology
Rodrigo Pereyra, Florencia Celeste Mansilla, Marcos Ivan Petersen, Victor Suarez, Alejandra Victoria Capozzo
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2019)
Article
Agriculture, Dairy & Animal Science
Danilo Bucafusco, Rodrigo Pereyra, Florencia C. Mansilla, Dario A. Malacari, Maria S. Juncos, Sebastian Di Giacomo, Andrea F. Ayude, Mariano Perez-Filgueira, Alejandra Capozzo
JOURNAL OF DAIRY SCIENCE
(2019)
Review
Immunology
D. J. Paton, R. Reeve, A. V. Capozzo, A. Ludi
Article
Multidisciplinary Sciences
Florencia Celeste Mansilla, Cecilia Soledad Turco, Maria Cruz Miraglia, Fernando Anibal Bessone, Raul Franco, Mariano Perez-Filgueira, Juan Manuel Sala, Alejandra Victoria Capozzo
Article
Microbiology
Walter Rodrigo Pereyra, Victor Humberto Suarez, Nancy Cardoso, Ignacio Gual, Gabriela Marcela Martinez, Alejandra Victoria Capozzo, Florencia Celeste Mansilla
Summary: The study determined a high seroprevalence of Neospora caninum in cattle in Valle de Lerma, province of Salta, Argentina, with a prevalence of acute infections. It also found a negative association between seroprevalence and the avidity index of specific antibodies, indicating a higher seroprevalence in animals with acute infections. Grazing fields showed more recent infections, highlighting the importance of control programs considering different risk factors that affect the epidemiological situation of the disease.
REVISTA ARGENTINA DE MICROBIOLOGIA
(2021)
Article
Immunology
Maria Eugenia Quintana, Nancy Patricia Cardoso, Rodrigo Pereyra, Lucas Jose Barone, Florencia Mariel Barrionuevo, Florencia Celeste Mansilla, Cecilia Soledad Turco, Alejandra Victoria Capozzo
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2020)
Editorial Material
Public, Environmental & Occupational Health
Alejandra Victoria Capozzo
FRONTIERS IN PUBLIC HEALTH
(2020)
Editorial Material
Veterinary Sciences
Alejandra V. Capozzo, Mariano Perez-Filgueira, Wilna Vosloo, Cyril G. Gay
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Virology
Sebastian Di Giacomo, Danilo Bucafusco, Juan Manuel Schammas, Juan Pega, Maria Cruz Miraglia, Florencia Barrionuevo, Alejandra Victoria Capozzo, Daniel Mariano Perez-Filgueira
Summary: Foot-and-mouth disease (FMD) remains a major threat to animal health worldwide. The variability of FMDV antigen poses challenges to vaccine-based control strategies. This study analyzed the immune responses of vaccinated cattle and their associations with clinical outcomes after infection with a different strain of FMDV.
Article
Veterinary Sciences
Nancy Patricia Cardoso, Florencia Celeste Mansilla, Estefania Benedetti, Cecilia Soledad Turco, Lucas Jose Barone, Javier Alonso Iserte, Ivana Soria, Elsa Baumeister, Alejandra Victoria Capozzo
FRONTIERS IN VETERINARY SCIENCE
(2020)