期刊
VACCINE
卷 35, 期 51, 页码 7088-7094出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2017.10.094
关键词
FMDV; CVC1302; Long-term humoral response; Germinal center; T follicular helper cell
资金
- Jiangsu Agriculture Science and Technology Innovation Fund (JASTIF) [CX (15) 1062]
- Agro-scientific Research in the Public Interest [201303046]
Long-lasting humoral immunity is one of the necessary criteria for a successful vaccine. In our previous study, it was demonstrated that the immunopotentiator CVC1302 could improve the humoral immunity induced by the foot and mouth disease virus (FMDV) killed vaccine (KV) with only one dose. Significantly higher FMDV-specific antibody titers and more persistent antibody responses were observed in pigs receiving CVC1302-adjuvanted IN (IN-CVC1302) than in those inoculated with KV alone. In this study, we show that CVC1302 enhances murine IgG responses to FMDV by promoting a potent T follicular helper cell (T-FH) response, which directly controls the magnitude of the germinal center (GC) B cell response. These results indicate a need for studies to assess the capacity of CVC1302 to enhance the efficacy of FMDV IN immunization in pigs, and provide new insights into the development of FMDV vaccines. (C) 2017 Elsevier Ltd. All rights reserved.
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