Article
Chemistry, Physical
Paurnima Talele, Anand Jadhav, Shivaji Tayade, Saugata Sahu, Kiran Kumar Sharma, Navinchandra Shimpi
Summary: Solid lipid nanoparticles (SLNs) loaded with hydroquinone (HQ) were successfully prepared using stearic acid and cationic/anionic emulsifiers. The physicochemical characterization of SLNs was performed, and the release behavior of HQ from SLNs was studied using an electrochemical method. The results showed that the concentration of emulsifier had a significant impact on the encapsulation and release of HQ.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biotechnology & Applied Microbiology
A. R. Neves, L. van der Putten, J. F. Queiroz, M. Pinheiro, S. Reis
Summary: Curcumin, a compound with potent neuroprotective activity, faces challenges in terms of bioavailability, leading to the development of SLNs and NLCs loaded with curcumin and functionalized with transferrin to improve its delivery to the brain. These nanosystems showed stable characteristics and enhanced permeability through the BBB, making them promising for curcumin brain delivery and protection.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ewelina Musielak, Agnieszka Feliczak-Guzik, Izabela Nowak
Summary: Solid lipid nanoparticles (SLNs) have been synthesized as potential drug delivery systems capable of carrying both hydrophilic and hydrophobic drugs. This study successfully developed SLNs suitable for the incorporation of curcumin, with high encapsulation efficiency and stability achieved through optimization of nanoparticle composition and encapsulation conditions.
Article
Pharmacology & Pharmacy
Eliza Wolska, Marta Brach
Summary: The distribution of drug substances in solid lipid microparticles (SLM) was studied in order to distinguish the localization of drugs in the lipid matrix and on the surface of the microspheres. The traditional characterization methods based on entrapment efficiency (EE) and drug loading (DL) parameters were found to be insufficient. A new distribution test method was proposed to demonstrate the localization of drugs within the microspheres. This research provides new opportunities for the development and use of SLM as a carrier for prolonged drug release and other advantages.
Article
Chemistry, Multidisciplinary
Sooho Yeo, Min Je Kim, Young Key Shim, Il Yoon, Woo Kyoung Lee
Summary: In this study, a solid lipid nanoparticle (SLN) system was developed to enhance the bioavailability of curcumin (Cur), and its potential for anticancer therapy was confirmed.
Article
Biochemistry & Molecular Biology
Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir
Summary: Solid lipid nanoparticles were designed to improve the oral bioavailability of acyclovir in the treatment of herpes simplex infection. The optimized formulation showed good quality with controlled release property and achieved a five-fold increase in oral bioavailability compared to commercial acyclovir suspension in rats. This study suggests that solid lipid nanoparticles could be a promising oral drug delivery vehicle for acyclovir due to their excellent properties.
Review
Pharmacology & Pharmacy
Claudia Viegas, Ana B. Patricio, Joao M. Prata, Akhtar Nadhman, Pavan Kumar Chintamaneni, Pedro Fonte
Summary: Solid-lipid nanoparticles and nanostructured lipid carriers are delivery systems that enhance drug solubility, permeability, and bioavailability. The use of liquid and solid lipids in nanostructured lipid carriers allows for higher drug loading, improved drug release properties, and increased stability. This review discusses the production methods, characterization, and performance of solid lipid nanoparticles and nanostructured lipid carriers, and also addresses the toxicity concerns.
Article
Materials Science, Multidisciplinary
Sanjay Sharma, Abhishek Kanugo, Juilee Gaikwad
Summary: Tazarotene's poor solubility and bioavailability have limited its applications for the treatment of psoriasis and acne. A study was conducted to develop solid lipid nanoparticles (SLN) of Tazarotene for effective topical delivery, with glyceryl monostearate identified as the best lipid and a combination of tween-span as a surfactant for SLNs. The optimized batch showed a zeta potential of -10.3 Mv and a drug release of 59% to 77% after 6 hours.
MATERIALS TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mahdi Hatami, Maryam Kouchak, Alireza Kheirollah, Layasadat Khorsandi, Mojtaba Rashidi
Summary: The study demonstrates that quercetin-solid lipid nanoparticles (QC-SLN) can significantly reduce cell viability, inhibit colony formation, suppress angiogenesis, and promote apoptosis in triple-negative breast cancer cells.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Food Science & Technology
Yasi Yu, Dechu Chen, Yee Ying Lee, Nannan Chen, Yong Wang, Chaoying Qiu
Summary: Curcumin-loaded solid lipid nanoparticles (Cur-SLN) were prepared using different lipid matrix (MLCD or TP) and three surfactants (T20, SQ, and Rha). The MLCD-based SLNs had smaller size and lower surface charge, while the Rha-based SLNs showed small size but low stability. The emulsifiers had an impact on crystal polymorphism and bioavailability, with T20-SLNs exhibiting higher digestibility and bioavailability. Mathematical modeling analysis showed that Cur was mainly released from the intestinal phase, and T20-SLNs had a faster release rate.
Review
Immunology
Aleksandra Zielinska, Piotr Eder, Jacek Karczewski, Marlena Szalata, Szymon Hryhorowicz, Karolina Wielgus, Milena Szalata, Agnieszka Dobrowolska, Atanas G. Atanasov, Ryszard Slomski, Eliana B. Souto
Summary: This study discusses the use of monoclonal antibodies for targeted drug delivery in the treatment of COVID-19. It proposes the use of solid lipid nanoparticles (SLN) loaded with tocilizumab (TCZ) and cannabidiol (CBD) for oral administration. TCZ attenuates cytokine storm in SARS-CoV-2 infected patients, while CBD has anti-inflammatory properties and can modulate gene expression. The use of SLN for oral administration of TCZ-tailored CBD-loaded SLN shows potential in managing SARS-CoV-2 and related infections. Rating: 7/10
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Masoumeh Alanchari, Maryam Mohammadi, Fatemeh Yazdian, Hossein Ahangari, Nahid Ahmadi, Zahra Emam-Djomeh, Aziz Homayouni-Rad, Ali Ehsani
Summary: This study aimed to design a delivery system for curcumin loaded solid lipid nanoparticles for evaluating antimicrobial properties in hamburger patty. The optimized nanoparticles showed good particle size, zeta potential, and high antimicrobial effect against foodborne pathogens. This research provides insights into the preparation of novel antimicrobial nanoparticles for food safety applications.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Saili Jagdale, Mahavir Narwade, Afsana Sheikh, Shadab Md, Rajesh Salve, Virendra Gajbhiye, Prashant Kesharwani, Kavita R. Gajbhiye
Summary: Site-specific delivery of anti-cancer drugs is a major challenge in cancer treatment. Lipid-based nanocarriers, particularly solid lipid nanoparticles (SLN), offer promising drug delivery properties. In this study, we developed GLcNAc-PTX-SLN to target ovarian cancer cells over-expressing GLUT1 transporters, and demonstrated higher cellular uptake and significant cytotoxic effect through confocal microscopy, MTT assay, and flow cytometry study.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Chao Pi, Wenmei Zhao, Mingtang Zeng, Jiyuan Yuan, Hongping Shen, Ke Li, Zhilian Su, Zerong Liu, Jie Wen, Xinjie Song, Robert J. Lee, Yumeng Wei, Ling Zhao
Summary: The aim of this study was to improve the therapeutic potential of a combination regimen of paclitaxel and curcumin using solid lipid nanoparticles (SLNs). The SLNs effectively co-encapsulated paclitaxel and curcumin, resulting in a reduced dosage while maintaining the same therapeutic effect. The SLNs improved area under the curve, prolonged residence time, and increased half-life, achieving long circulation. In a mouse tumor model, the SLNs exhibited a higher tumor suppression rate compared to paclitaxel or the combination of curcumin and paclitaxel.
Article
Pharmacology & Pharmacy
Farhad Mohammadi, Rashin Giti, Mohsen Nabi Meibodi, Ali Mohammad Ranjbar, Ahmad Reza Bazooband, Vahid Ramezani
Summary: This study successfully loaded kojic acid dipalmitate (KAD) in solid lipid nanoparticles (SLNs) as a drug delivery platform for topical delivery. The SLN-based KAD cream showed higher KAD concentration in the epidermis compared to other formulations, suggesting its suitability as a proper topical formulation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Oncology
M. Khodaei, K. Rostamizadeh, A. H. Taromchi, H. Monirinasab, M. Fathi
Summary: Using new lipid-polymer hybrid nanoparticles as a carrier for siRNA, efficient silencing of IGF-1R gene overexpression in MCF-7 human breast cancer cell line was achieved. The complex showed optimal efficiency at N/P ratio of 40 with a high siRNA encapsulation rate of 95%. It demonstrated superior down-regulation of the target gene compared to controls.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Engineering, Biomedical
Mohammad Yoozbashi, Hamid Rashidzadeh, Mehraneh Kermanian, Somayeh Sadighian, Mir-Jamal Hosseini, Zahra Kaboli, Kobra Rostamizadeh
Summary: In this study, magnetic nanostructured lipid carriers (Mag-NLCs) were synthesized for the delivery of curcumin (CUR), showing temperature-dependent release rates. Evaluation of mitochondrial toxicity revealed no specific toxic effects of CUR-Mag-NLCs and curcumin on isolated mitochondria.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Engineering, Biomedical
Mina Habibizadeh, Samad Nadri, Ali Fattahi, Kobra Rostamizadeh, Parvin Mohammadi, Sina Andalib, Mehrdad Hamidi, Narges Forouzideh
Summary: This study developed a novel three-dimensional nanocomposite scaffold by surface modification, showing enhanced biocompatibility and improved proliferation of conjunctiva mesenchymal stem cells (CJMSCs) towards neuron-like cells.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Pharmacology & Pharmacy
Afsaneh Mennati, Kobra Rostamizadeh, Hamidreza Kheiri Manjili, Mir Ali Mousavi, Mina Zhiani, Izatalloh Sabouri, Elahe Attari, Mojtaba Fathi, Hossein Danafar
Summary: This study focuses on using polymer lipid hybrid nanocarriers for delivering lycopene, a natural antioxidant that plays a role in regulating cell signaling and cell cycle, for enhanced anti-tumor effects. By applying mPEG-PCL-DDAB as a potent nanocarrier, it shows promise for drug delivery to breast cancer cell lines MCF-7 and as a potential anti-cancer therapeutic approach.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Environmental
Mozhgan Shajari, Mostafa Zamani, Nahid Ahmadi, Kobra Rostamizadeh, Reza Shapouri
Summary: This research investigated the antibacterial effect of curcumin entrapped in polymeric nanoparticles on resistant bacteria, showing a stronger impact on wild strains. Additionally, it was found that mPEG-PCL/curcumin can reduce the total microbial count in wastewater at specific concentrations and temperatures.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Parasitology
Mehdi Farhadi, Ali Haniloo, Kobra Rostamizadeh, Nahid Ahmadi
Summary: The study demonstrated that the ABZ-NLCs are significantly more efficient in treating and preventing the development of Echinococcus granulosus protoscoleces, metacestodes, and cysts in mice compared to free ABZ. ABZ-NLCs lead to more effective treatment of these parasites.
PARASITOLOGY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Mostafa Zamani, Mozhgan Aghajanzadeh, Ali Sharafi, Kobra Rostamizadeh, Hossein Danafar
Summary: In this project, a biocompatible block copolymer was synthesized and conjugated with folic acid and curcumin to prepare an anticancer nano carrier. Various evaluations and experiments confirmed the efficiency of the carrier in both in vitro and in vivo anti-cancer effects and biocompatibility.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Mozhgan Shajari, Nahid Ahmadi, Mostafa Zamani, Kobra Rostamizadeh, Reza Shapouri
Summary: In this study, eco-friendly nanostructured lipid carriers (NLCs) were used as delivery agents to control bacterial growth in hospital wastewater by properly delivering an antibacterial agent. The results showed that the prepared NLCs effectively inhibited bacterial growth in both culture media and hospital wastewater, indicating their potential to control bacterial growth. The gradual release of the antibacterial agent from the NLC nanoparticles offers a promising approach for wastewater treatment.
WATER ENVIRONMENT RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Mozhgan Shajari, Kobra Rostamizadeh, Reza Shapouri, Lobat Taghavi
Summary: In this study, eugenol-loaded mPEG-PCL nanoparticles were used to enhance the antibacterial properties of eugenol and eliminate resistant bacteria. The nanoparticles showed significant antibacterial effects on wild gram-negative bacteria strains at a certain concentration and demonstrated a decrease in total microbial count in hospital wastewater.
Article
Food Science & Technology
Jouhaina Hadree, Fakhri Shahidi, Mohebbat Mohebbi, Mohammadreza Abbaspour
Summary: This study investigated the effects of pomegranate peel extract concentration, drying temperature, and feed flow rate on the properties of pomegranate juice powder produced by spray drying. The optimal conditions for powder production were determined using response surface methodology. The results showed that the phenolic extract concentration, drying temperature, and feed flow rate significantly influenced various properties of the powder. The study concluded that the spray drying conditions did not negatively affect the phenolic compound content in pomegranate powder, making it suitable for use as a food additive or dietary supplement.
Article
Integrative & Complementary Medicine
Shabnam Shahidi, Kobra Rostamizadeh, Mojtaba Fathi, Keivan Nedaei, Ali Ramazani
Summary: This study confirmed the involvement of integrins in cancer resistance following chemotherapy using Regorafenib, and suggested that siRNA targeting integrin could enhance the effects of plant derivatives like Quercetin to reverse resistance in vitro.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Plant Sciences
Borzoo Taami, Kobra Rostamizadeh, Majid Aminzare, Hassan Hassanzadazar
Summary: This study evaluated the antioxidant effects of biodegradable starch film containing nanoemulsions of Bunium persicum essential oil fortified with Cinnamaldehyde. The nanofilm showed strong antioxidant activity, increasing with higher concentrations of essential oil and Cinnamaldehyde. However, combining or fortifying the nanofilm with other active ingredients is not recommended.
JOURNAL OF MEDICINAL PLANTS AND BY-PRODUCTS-JMPB
(2022)
Article
Oncology
Mina Zhiani, Mir Ali Mousavi, Kobra Rostamizadeh, Reza Pirizadeh, Abdolreza Osali, Afsaneh Mennati, Behrouz Motlagh, Mojtaba Fathi
Summary: The study showed that Integrin-beta 1 overexpression may lead to Regorafenib resistance, and combination therapy targeting Integrin-beta 1 and Regorafenib could decrease Integrin-beta 1 gene expression, increase apoptosis rate, potentially inducing drug sensitivity.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Chemistry, Applied
Samira Zarei, Somayeh Sadighian, Kobra Rostamizadeh, Maryam Khalkhali
Summary: The MCS nanoparticles prepared by the o/w emulsion method showed a well-shaped spherical structure and superparamagnetic properties, making them sensitive to external magnetic fields for magnetic drug delivery. These nanoparticles exhibited sustained release behavior in phosphate-buffered saline and showed potential as a T2 MRI contrast agent.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2021)
Article
Food Science & Technology
Zahra Abbasi, Majid Aminzare, Hassan Hassanzad Azar, Kobra Rostamizadeh
Summary: The study showed that corn starch coatings incorporated with nanoemulsions had better antimicrobial activities on chicken meat compared to conventional forms. The NZEOC treatment displayed the best antimicrobial properties during storage and is recommended as a natural preservative to enhance the microbial stability of poultry meat.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)