Article
Food Science & Technology
Zikun Li, Xiaohan Wang, Man Zhang, Hongjun He, Bin Liang, Chanchan Sun, Xiulian Li, Changjian Ji
Summary: In this study, EGCG-loaded BSA/PUL nanoparticles were successfully prepared with good stability and antioxidant activity. The formation of BPENs through self-assembly driven by hydrogen bonding ensured the desired EGCG loading efficiency. BPENs exhibited high antioxidant activity in vitro and sustained release over time.
Article
Chemistry, Applied
Ning Tang, Jiachen Liu, Yongqiang Cheng
Summary: The study revealed that binding of zinc to proteins can increase the affinity of proteins for EGCG and alter the binding sites of EGCG on proteins. In the case of myoglobin, zinc binding facilitated the electron transfer from EGCG to myoglobin by enhancing the binding of EGCG to myoglobin.
Article
Chemistry, Applied
Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang
Summary: This study investigates the binding of six flavonoids with BSA containing Cu2+ using UV-vis, fluorescence, and molecular docking. The results show that the complexation of Cu2+ significantly affects the binding of flavonoids with BSA.
Article
Chemistry, Multidisciplinary
Wei Xu, Yuli Ning, Shiwan Cao, Guanchen Wu, Haomin Sun, Liwen Chai, Shuping Wu, Jingyi Li, Denglin Luo
Summary: The interaction mechanism between bovine serum albumin (BSA) and tannic acid (TA) was investigated using spectroscopic and computational approaches, and validated by circular dichroism (CD), differential scanning calorimetry (DSC), and molecular docking techniques. The fluorescence spectra and molecular docking results indicated that TA bound to BSA and caused static quenching at a single binding site. The interaction between BSA and TA was dose-dependent. Thermodynamic analysis showed that hydrophobic forces played a dominant role in the BSA-TA interaction. The stability of the BSA-TA complex was enhanced, as evidenced by changes in secondary structure and increased melting temperature and enthalpy.
Article
Biochemistry & Molecular Biology
Zhe-Ying Hu, Wan-Jun Wang, Lu Hu, Jie-Hua Shi, Shao-Liang Jiang
Summary: Dacomitinib, a tyrosine kinase inhibitor, was found to quench the endogenous fluorescence of bovine serum albumin (BSA) through static quenching. It preferentially inserted into the hydrophobic cavity of the BSA subdomain IA (site III), forming a 1:1 DAC-BSA complex. DAC had a higher affinity for BSA, and non-radiative energy transfer occurred between them. Hydrogen bonds, van der Waals forces, and hydrophobic forces played a significant role in the insertion of DAC into the hydrophobic cavity of BSA. DAC affected the secondary structure of BSA, leading to a slight decrease in the alpha-helix content. The microenvironment around tyrosine residues was affected by the DAC-BSA combination, while the microenvironment around tryptophan residues remained unaffected. Molecular docking and molecular dynamics simulation confirmed the insertion of DAC into site III of BSA, with hydrogen energy and van der Waals energy contributing to the stability of the DAC-BSA complex. The influence of metal ions on the system's affinity was also explored.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Applied
Xin Qi, Duoxia Xu, Jinjin Zhu, Shaojia Wang, Jingwei Peng, Wei Gao, Yanping Cao
Summary: The interaction between lutein dipalmitate and BSA was found to be static with a binding stoichiometry of 1:1. Thermodynamic study and molecular docking confirmed that lutein dipalmitate spontaneously bound to BSA through hydrogen bonds, van der Waals forces, and hydrophobic interactions. The addition of lutein dipalmitate led to a decrease in the alpha-helix content of BSA, as observed through CD analysis.
FOOD HYDROCOLLOIDS
(2021)
Article
Agriculture, Multidisciplinary
Siqi Luo, Xiuli Sun, Meng Huang, Qianhui Ma, Libo Du, Yan Cui
Summary: A new exosome-based delivery system for ECG was designed and studied for its neuroprotective effects in a PD model, showing successful delivery of ECG into cells and enhanced neuroprotection against Rot-induced damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ashima Thakur, Jayant Patwa, Suyash Pant, Abha Sharma, S. J. S. Flora
Summary: The study investigated the interaction between MiADMSA and BSA, finding that MiADMSA can influence the conformation of BSA, and the interaction is spontaneous, endothermic, and involves hydrophobic forces. Experimental and computational studies demonstrated the effective binding of MiADMSA with BSA, essential for drug transportation and elimination from the body.
SCIENTIFIC REPORTS
(2021)
Article
Spectroscopy
Ye Li, Hongrui Liu, Chunyu Mu, Jiali Gu, Chun Li
Summary: This study investigated the interaction mechanism between ethoxyquin (EQ) and transporter protein before and after beta-cyclodextrin (beta-CD) encapsulation. The results showed that EQ formed complexes with bovine serum albumin (BSA) and affected its structure and environment. However, encapsulation in beta-CD reduced the binding ability of EQ to BSA and prevented adverse effects on BSA conformation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Chemistry, Applied
Hui Zhang, Yanzhen Zhang, Yongqi Huang, Ling Wu, Qianwan Guo, Qi Wang, Li Liang, Katsuyoshi Nishinari, Meng Zhao
Summary: The study revealed the weak interaction between COS2-6 and BSA, primarily stabilized by electrostatic and hydrophobic forces, providing important insights into the potential of COS in food applications.
Article
Chemistry, Physical
Rong-Juan Zhang, Song-Bo Kou, Lu Hu, Li Li, Jie-Hua Shi, Shao-Liang Jiang
Summary: In this study, the interaction between Baricitinib (BRT) and bovine serum albumin (BSA) was investigated. The results showed a weak binding between BRT and BSA, with van der Waals forces and hydrogen bonds playing a critical role in the complexation process. The findings provide important insights for evaluating the pharmacological characteristics of BRT and designing new drugs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Liurong Huang, Lulu Qu, Shifang Jia, Shuang Ding, Jun Zhao, Feng Li
Summary: The study found that allicin affects the fluorescence properties of bovine serum albumin, the number of binding sites, binding constants, and leads to changes in its structure, including instability in secondary and tertiary structure and exposure of more hydrophobic groups.
PROCESS BIOCHEMISTRY
(2022)
Article
Spectroscopy
Md. Zahirul Kabir, Hafsa Tayyab, Cem Erkmen, Sevinc Kurbanoglu, Saharuddin B. Mohamad, Bengi Uslu
Summary: The interactive association between the antifungal drug climbazole (CBZ) and the carrier protein bovine serum albumin (BSA) was investigated using fluorescence, absorption spectroscopy, and in silico techniques. The results confirmed the formation of a complex between CBZ and BSA. Hydrophobic forces, van der Waals forces, and hydrogen bonds were found to play key roles in stabilizing the complex. The binding of CBZ to BSA occurred near Sudlow's sites I and II, with a greater preference for site II.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Applied
Jiali Gu, Siyao Zheng, Xiyao Huang, Qian He, Ting Sun
Summary: The study found that the binding of BHA to serum albumin occurs through static quenching, forming a relatively stable complex with hydrophobic interactions as the main binding mechanism. BHA has the capability to bind to specific sites on BSA, and the presence of other food additives weakens the binding of BHA to BSA.
Article
Food Science & Technology
Huanhuan Dong, Xin Yin, Wusigale, Hao Cheng, Narangerel Choijilsuren, Xing Chen, Li Liang
Summary: Proteins were investigated for their effects on the interactions between bioactive compounds, in order to select suitable co-encapsulation strategies. Mixing different pairs of compounds had varying effects on antioxidant activity, with BSA improving FRAP but decreasing ABTS inhibition in mixtures.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Chemical
Eddy Plasquy, Jose Maria Garcia Martos, Maria del Carmen Florido Fernandez, Rafael Ruben Sola-Guirado, Juan Francisco Garcia Martin
Summary: The study examines the use of warm water to warm up olives before grinding to maintain a desired temperature, which is crucial for high-quality oil extraction. Results show the feasibility of the method and potential for further automation to improve efficiency and quality in olive processing.
Review
Engineering, Chemical
Francisco Jose Sanchez-Borrego, Paloma Alvarez-Mateos, Juan F. Garcia-Martin
Summary: Bio-oil is a promising source of chemicals and renewable fuels that can replace fossil fuels and be produced through pyrolysis. It contains various value-added chemicals, such as aromatic compounds, suitable for a range of applications.
Editorial Material
Engineering, Chemical
Miguel Torres-Garcia, Paloma Alvarez-Mateos, Juan Francisco Garcia-Martin
Article
Food Science & Technology
Chao-Hui Feng, Chiko Otani, Yuichi Ogawa, Juan F. Garcia-Martin
Summary: The Terahertz time-domain spectroscopy (THz-TDS) system was used to analyze the spectral changes of sausage hog and sheep casings before and after casing modification, showing higher absorbances for modified cases. The drying process under nitrogen gas significantly reduced the drying time for natural hog casing made from soy oil.
Article
Engineering, Chemical
Carmen C. Barrios, Paloma Alvarez-Mateos, Ana Uruena, David Diez, Juan Francisco Garcia-Martin
Summary: The study aimed to assess the impact of adding an oxygenated additive to biodiesel in reducing particle emissions from engines without diesel particle filters. Results showed that certain blends increased NOx emissions, while one specific blend significantly reduced total particle number and NOx emissions.
Article
Food Science & Technology
Karine Cristine Kaufmann, Klicia Araujo Sampaio, Juan F. Garcia-Martin, Douglas Fernandes Barbin
Summary: The study demonstrates that coriander oil can be effectively distinguished from adulterated oils using principal component analysis, linear discriminant analysis, and k-nearest neighbors algorithm. The performance of Partial Least Squares regression models also shows their potential utility in quality control processes.
Article
Agronomy
Francisco-Jose Sanchez-Borrego, Noelia Garcia-Criado, Juan F. Garcia-Martin, Paloma alvarez-Mateos
Summary: This study investigates the pyrolysis of orange waste and orange pruning to produce biochar and bio-oil for high-added-value compounds. The obtained biochar showed potential for reducing the sulphur content in waste cooking oil.
Article
Plant Sciences
Francisco Jose Sanchez-Borrego, Tomas Juan Barea de Hoyos-Limon, Juan Francisco Garcia-Martin, Paloma Alvarez-Mateos
Summary: Olive stones can be valorized through pyrolysis to obtain biochar and bio-oil, with temperature being the key parameter affecting the product distribution. Impregnated olive stones result in higher amounts of high-added-value products. The specific surface area of biochar has an impact on the esterification yield.
Review
Chemistry, Analytical
Juan Francisco Garcia Martin
Summary: The physico-chemical parameters of olive oil quality can be effectively measured using near-infrared spectroscopy (NIRS), with high precision for several important parameters. NIRS is suitable for predicting nutritional contents and has the potential for analyzing other parameters, although further improvement of mathematical models is required.
Article
Engineering, Chemical
Sebastian Sanchez, Inmaculada Olivares, Juan G. Puentes, Rafael Orpez, M. Dolores La Rubia, Rafael Pacheco, Juan F. Garcia Martin
Summary: The addition of high-purity NMT improved the extraction yields and quality of olive oil, especially enhancing the content of antioxidant compounds and increasing the oxidative stability of the oil.
Editorial Material
Engineering, Chemical
Juan Francisco Garcia Martin, Miguel Torres Garcia, Paloma Alvarez Mateos
Review
Acoustics
Qing-An Zhang, Hongrong Zheng, Junyan Lin, Guangmin Nie, Xuehui Fan, Juan Francisco Garcia-Martin
Summary: As a non-thermal physical technology, ultrasound is widely used in various food processing operations, including filtration, freezing, thawing, sterilization, cutting, extraction, aging, etc. It is also applied in the processing of meat products, fruits and vegetables, and dairy products. However, there is a lack of systematic sorting and summarizing of the impact of ultrasound on different characteristics of wine. This review aims to systematically summarize the current achievements and problems of ultrasound application in winemaking, including extraction, fermentation, aging, and sterilization, and discuss its advantages, disadvantages, and future development.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Engineering, Chemical
Antonio Rosales Martinez, Juan F. Garcia-Martin, Ignacio Rodriguez-Garcia
Summary: Significant efforts have been made to develop sustainable reduction reactions for organic and bioorganic compounds, with the selection of reagents and solvents playing a crucial role. Cp2TiCl/H2O has emerged as a safe, efficient, selective, and low-cost reagent, offering a sustainable alternative for organic compound reduction. This study focuses on describing the intermediates, mechanisms, and representative examples to enhance understanding of reductions facilitated by this system. Future perspectives are discussed, including the use of its analog Cp2TiCl/D2O as a powerful tool for preparing deuterated phenols as internal standards for analyzing bioactive phenols in olive oil.
Article
Engineering, Chemical
Fangchen Ding, Changzhou Zuo, Juan Francisco Garcia-Martin, Yan Ge, Kang Tu, Jing Peng, Hongmei Xiao, Weijie Lan, Leiqing Pan
Summary: Different packaging materials, such as PVC, PE, and EPE, have significant effects on the near infrared (NIR) prediction of mango quality. The spectral interferences resulting from these materials can be reduced using spectral filtering methods. Combining spectral filtering with variable selection methods can further improve the prediction accuracy of mango quality parameters.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Manuel Cuevas, Juan F. Garcia Martin, Vicente Bravo, Sebastian Sanchez
Summary: This study investigated the potential of producing bioethanol from olive stones through liquid hot-water pre-treatment and subsequent enzymatic hydrolysis. The results showed that under the most suitable conditions, 6.4 dm(3) of ethanol per 100 kg of olive stones could be produced through this process.
FERMENTATION-BASEL
(2021)
