Article
Multidisciplinary Sciences
Li Tang, Chengming Guo, Xu Li, Bo Zhang, Liuye Huang
Summary: TAF15 is significantly upregulated in gastric cancer tissues and cell lines, and promotes cell proliferation, migration, and invasion in gastric cancer via the RAF1/MEK/ERK signaling pathway. This suggests that TAF15 may serve as a potential molecular diagnostic marker or therapeutic target for gastric cancer.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Zhiyuan Huang, Fang Li, Qinchuan Li
Summary: Global studies have shown the involvement of RNA binding proteins in the development of cervical cancer, with few studies focusing on their correlation with overall survival of patients. Our investigation identified significant DEGs related to cervical cancer progression, with potential as prognostic biomarkers and treatment targets for CC patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Xun-Xi Lu, Wen-Xiao Yang, Yu -Chen Pei, Hong Luo, Xiao-Guang Li, Yun-Jin Wang, Guo-Liang Zhang, Hong Ling, Zhi-Ming Shao, Xin Hu
Summary: Dysregulation of RNA-binding proteins (RBPs) is a characteristic of cancer. Investigating the functions and mechanisms of abnormal RBPs can help identify new cancer biomarkers and treatment strategies. In this study, SNRPC was identified as an oncogenic modulator in triple-negative breast cancer (TNBC). SNRPC upregulation was associated with poor prognosis, and its inhibition impaired TNBC cell proliferation, migration, and invasion. SNRPC also contributed to the stability of U1 snRNP and the transcriptional program controlled by RNA Pol II. Knockdown of SNRPC reduced the expression of oncogenes and inhibited TNBC progression via the TNFAIP2-Rac1-β-catenin signaling pathway.
Review
Cell Biology
Zhonghao Mao, Bingyu Wang, Teng Zhang, Baoxia Cui
Summary: This article discusses the biogenesis of m6A, atypical expressions of m6A regulators, and their functions in cervical cancer. The modification of m6A in non-coding RNA is also elucidated. In the context of precision medicine, the application of m6A in clinical diagnosis and treatment of cervical cancer is summarized. Additionally, new perspectives on detection methods, immune regulation, and nano-drug development are presented.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Xiaojuan Fan, Yun Yang, Chuyun Chen, Zefeng Wang
Summary: Circular RNAs (circRNAs) have been found to be translated through IRES-driven mechanism. Short elements that drive circRNA translation have been identified, suggesting a pervasive cap-independent translation in the human transcriptome.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Haijian Cai, Dandan Zheng, Yizhu Yao, Lehe Yang, Xiaoying Huang, Liangxing Wang
Summary: Embryonic lethal abnormal vision-like (ELAVL) proteins are RNA binding proteins that regulate the development and functioning of the nervous system. They not only exist in the nervous system, but also have regulatory effects in other tissues. ELAVL proteins stabilize multiple mRNAs and promote tumor development, making them potential therapeutic targets. Additionally, they also interact with non-coding RNAs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marc Lavigne, Olivier Helynck, Pascal Rigolet, Rofia Boudria-Souilah, Mireille Nowakowski, Bruno Baron, Sebastien Brule, Sylviane Hoos, Bertrand Raynal, Lionel Guittat, Claire Beauvineau, Stephane Petres, Anton Granzhan, Jean Guillon, Genevieve Pratviel, Marie-Paule Teulade-Fichou, Patrick England, Jean-Louis Mergny, Helene Munier-Lehmann
Summary: The study revealed that the SARS-CoV-2 Nsp3 protein contains a SUD domain that interacts with G4s, which can be disrupted by preventing G4 structures from forming or using specific ligands. This opens up possibilities for further research on the role of SUD/G4 interactions in SARS-CoV-2 replication and the development of inhibitors as potential antiviral compounds.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Yuchao Diao, Yingwei Li, Zixiang Wang, Shourong Wang, Peng Li, Beihua Kong
Summary: Studies have shown that overexpression of SF3B4 in ovarian cancer patients is associated with poor prognosis, and miR-509-3p negatively regulates SF3B4 expression which in turn promotes ovarian cancer progression. Additionally, SF3B4's splicing of RAD52 also impacts the development of ovarian cancer.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Shuang Dai, Yan Huang, Ting Liu, Zi-Han Xu, Tao Liu, Lan Chen, Zhi-Wu Wang, Feng Luo
Summary: This study aimed to investigate the role of RNA-binding proteins in the survival of gastric adenocarcinoma. Through RNA sequencing and clinical data, five pivotal RBP genes were identified and used to construct a prognostic model with independent predictive value. The model showed good performance in predicting survival outcomes and could serve as a valuable tool for prognosis in gastric adenocarcinoma.
Article
Biochemistry & Molecular Biology
Huizhe Wu, Xiangyu Ding, Xiaoyun Hu, Qing Zhao, Qiuchen Chen, Tong Sun, Yalun Li, Hao Guo, Meng Li, Ziming Gao, Weifan Yao, Lin Zhao, Kai Li, Minjie Wei
Summary: This study uncovered an essential LINC021/IMP2/MSX1 and JARID2 signaling axis in CRC tumorigenesis, providing profound insights into the regulation of m(6)A modification by lncRNA in CRC initiation and progression and suggesting a potential target for CRC treatment.
Article
Biochemistry & Molecular Biology
Marylin Rheault, Sophie E. Cousineau, Danielle R. Fox, Quinn H. Abram, Selena M. Sagan
Summary: In this study, the different roles of miR-122 in the HCV life cycle were isolated and evaluated using mutations, mutant miRNAs, and HCV luciferase reporter RNAs. The results indicate that the riboswitch has minimal contribution, while genome stability and translational promotion have similar contributions in the establishment phase of infection. However, in the maintenance phase, translational promotion becomes the dominant role. Additionally, an alternative conformation of the 5' untranslated region, termed SLIIalt, was found to be important for efficient virion assembly.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jiyeon Park, Dongmoung Kim, Jin-Ok Lee, Hyeon-Chun Park, Brian Y. Ryu, Ju Han Kim, Sug Hyung Lee, Yeun-Jun Chung
Summary: Two potential biomarkers have been discovered by South Korean scientists that could help classify subtypes of papillary thyroid cancer more accurately, leading to improved treatment plans. This study provides insights into the molecular and histological subtypes of this common form of thyroid cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Xiaoling Li, Yunguan Wang, Su Deng, Guanghui Zhu, Choushi Wang, Nickolas A. Johnson, Zeda Zhang, Carla Rodriguez Tirado, Yaru Xu, Lauren A. Metang, Julisa Gonzalez, Atreyi Mukherji, Jianfeng Ye, Yuqiu Yang, Wei Peng, Yitao Tang, Mia Hofstad, Zhiqun Xie, Heewon Yoon, Liping Chen, Xihui Liu, Sujun Chen, Hong Zhu, Douglas Strand, Han Liang, Ganesh Raj, Housheng Hansen He, Joshua T. Mendell, Bo Li, Tao Wang, Ping Mu
Summary: This study reveals that SYNCRIP acts as an endogenous molecular brake to suppress APOBEC-driven mutagenesis in prostate cancer, which contributes to tumor heterogeneity and therapy resistance. Overactivated APOBEC3B, in SYNCRIP-deficient prostate cancer cells, is identified as a key mutator that generates driver mutations in frequently mutated genes in prostate cancer, including FOXA1 and EP300. Functional screening identifies eight crucial driver genes (BRD7, CBX8, EP300, FOXA1, HDAC5, HSF4, STAT3, and AR) mutated by APOBEC3B, which confer resistance to androgen receptor-targeted therapy in prostate cancer.
Article
Cell Biology
Fangfang Li, Chen Zhao, Yuchao Diao, Zixiang Wang, Jiali Peng, Ning Yang, Chunping Qiu, Beihua Kong, Yingwei Li
Summary: The latest research suggests that RNA-binding proteins (RBPs) may be new potential targets for cancer treatment. The study identified MEX3A as an important RBP associated with the clinical prognosis of ovarian cancer. Overexpression of MEX3A promoted proliferation and invasion of ovarian cancer cells, while knockdown suppressed their development and invasion. Additionally, the study revealed TIMELESS as a critical downstream target of MEX3A.
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
Laura Regue, William Wang, Fei Ji, Joseph Avruch, Hua Wang, Ning Dai
Summary: IMP2 gene plays a crucial role in adipocyte development by promoting early commitment of adipocyte-derived stem cells into preadipocytes. It is also essential for maintaining white adipose tissue homeostasis. However, its contribution to insulin resistance, a major risk factor for T2D, is not clear.
Article
Biochemistry & Molecular Biology
Qi Sun, Run Shi, Xin Wang, Demin Li, Haiwei Wu, Binhui Ren
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Reproductive Biology
Qi Sun, Xing Huang, Quanli Zhang, Junwei Qu, Yang Shen, Xin Wang, Haijun Sun, Jie Wang, Lin Xu, Xiaoxiang Chen, Binhui Ren
JOURNAL OF OVARIAN RESEARCH
(2016)
Article
Oncology
Xin Wang, Qi Sun, Chen Chen, Rong Yin, Xing Huang, Xuan Wang, Run Shi, Lin Xu, Binhui Ren
Article
Oncology
Run Shi, Qi Sun, Jing Sun, Xin Wang, Wenjie Xia, Gaochao Dong, Anpeng Wang, Feng Jiang, Lin Xu
Article
Oncology
Xing Huang, Qi Sun, Chen Chen, Yi Zhang, Xin Kang, Jing-Yuan Zhang, Da-Wei Ma, Lei Xia, Lin Xu, Xin-Yu Xu, Bin-Hui Ren
Article
Oncology
Run Shi, Chunrong Zhang, Yaqin Wu, Xin Wang, Qi Sun, Jing Sun, Wenjie Xia, Gaochao Dong, Anpeng Wang, Feng Jiang, Lin Xu
Article
Oncology
Jing Luo, Kaichao Liu, Yu Yao, Qi Sun, Xiufen Zheng, Biqing Zhu, Quanli Zhang, Lin Xu, Yi Shen, Binhui Ren
Article
Oncology
Jing Luo, Yu Yao, Saiguang Ji, Qi Sun, Yang Xu, Kaichao Liu, Qiang Diao, Yong Qiang, Yi Shen
CANCER CELL INTERNATIONAL
(2019)
Article
Biotechnology & Applied Microbiology
Haijun Sun, Kaichao Liu, Jianfeng Huang, Qi Sun, Chenye Shao, Jing Luo, Lin Xu, Yi Shen, Binhui Ren
ONCOTARGETS AND THERAPY
(2019)
Article
Biochemistry & Molecular Biology
Haijun Sun, Qi Sun, Xie Qiu, Gongming Zhang, Guanghui Chen, Aimin Li, Jianhua Dai
Summary: By using bioinformatics, a novel oncogene WDR43, closely related to tumor progression in non-small cell lung cancer (NSCLC), was identified. High expression of WDR43 in NSCLC correlated with worse clinical symptoms and prognosis. Knocked down expression of WDR43 impaired migration, proliferation, and cell-cycle progression in NSCLC cell lines. WDR43 can interact with cyclin-dependent kinase 2 and induce the expression of cyclin proteins.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Oncology
Jing Luo, Zhongqiu Wang, Jianfeng Huang, Yu Yao, Qi Sun, Jie Wang, Yi Shen, Lin Xu, Binhui Ren
Article
Oncology
Yu Yao, Jing Luo, Qi Sun, Ting Xu, Siqing Sun, Meili Chen, Xin Lin, Qiuping Qian, Yu Zhang, Lin Cao, Po Zhang, Yong Lin
AMERICAN JOURNAL OF CANCER RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Quanli Zhang, Xiufen Zheng, Qi Sun, Run Shi, Jie Wang, Biqing Zhu, Lin Xu, Guangqin Zhang, Binhui Ren
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Oncology
Run Shi, Jing Sun, Qi Sun, Quanli Zhang, Wenjie Xia, Gaochao Dong, Anpeng Wang, Feng Jiang, Lin Xu
AMERICAN JOURNAL OF CANCER RESEARCH
(2016)