Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells

Statin use and risk of multiple myeloma: An analysis from the cancer research network

(2017) Mara M. Epstein et al.   INTERNATIONAL JOURNAL OF CANCER

Statin use and all-cause and cancer mortality: BioBank Japan cohort

(2017) Hiroshi Yokomichi et al.   JOURNAL OF EPIDEMIOLOGY

Statin improves survival in patients with EGFR-TKI lung cancer: A nationwide population-based study

(2017) Ming-Szu Hung et al.   PLoS One

Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells

(2016) Masanobu Tsubaki et al.   BIOMEDICINE & PHARMACOTHERAPY

Statins for Prevention of Cardiovascular Disease in Adults

(2016) Roger Chou et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

(2015) Bihter Atil et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition

(2014) Tamer A. Ahmed et al.   LEUKEMIA RESEARCH

Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway

(2012) Masanobu Tsubaki et al.   BIOCHEMICAL PHARMACOLOGY

Ras/ERK1 pathway regulation of p27KIP1-mediated G1-phase cell-cycle arrest in cordycepin-induced inhibition of the proliferation of vascular smooth muscle cells

(2012) Su-Mi Jung et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2

(2012) Masanobu Tsubaki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma

(2011) Masashi Yanae et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Combined Inhibition of MEK and Mammalian Target of Rapamycin Abolishes Phosphorylation of Cyclin-Dependent Kinase 4 in Glioblastoma Cell Lines and Prevents Their Proliferation

(2009) S. Paternot et al.   CANCER RESEARCH

Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics

(2009) Annette S. Gillings et al.   FEBS Journal

HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway

(2008) Dominik Fuchs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of extracellular signal-related kinase signaling in esculetin induced G1 arrest of human leukemia U937 cells

(2008) Shin Hwa Lee et al.   BIOMEDICINE & PHARMACOTHERAPY