期刊
EUROPACE
卷 18, 期 6, 页码 881-887出版社
OXFORD UNIV PRESS
DOI: 10.1093/europace/euv112
关键词
Ventricular premature depolarization; Cardiomyopathy; Arrhythmia
Most patients with idiopathic ventricular premature depolarizations (VPDs) complain of symptoms related to this arrhythmia, but some patients are asymptomatic even with a high VPD burden. Our understanding of the relationship between symptoms and cardiomyopathy related to this arrhythmia remains limited. We evaluated 801 subjects (381 men; mean age, 55 +/- 17 years) who visited our outpatient clinic. All subjects were diagnosed with frequent VPDs (1% or > 1000 beats/day). The patients were divided into two groups according to the presence or absence of typical VPD symptoms (palpitations or skipped beats during VPDs): symptomatic patients (n = 455) and asymptomatic patients (n = 346). Clinical and electrocardiogram parameters were compared between these two groups. In the symptomatic group, palpitations were the most frequent symptom (91%). Daily VPD burden (P = 0.90) and electrocardiogram parameters (P > 0.05) did not differ significantly between groups. The incidence of frequent VPDs with left ventricular dysfunction was significantly higher in the asymptomatic group (symptomatic patients, 3.0%; asymptomatic patients, 10.5%; P < 0.001). The absence of typical VPD-related symptoms may be a risk factor for cardiomyopathy and be associated with an adverse outcome.
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