Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Sang-Soo Park, Yea Seong Ryu, Dong-In Koh, Seung-Woo Hong, Jai-Hee Moon, Jae-Sik Shin, Mi Jin Kim, Do Yeon Kim, Jun Ki Hong, Eun Ho Kim, Hong-Rae Jeong, Yoon Sun Park, Joseph Kim, Dong Min Kim, Hyeseon Yun, Joo-Yeon Shin, Dong-Hoon Jin
Summary: SVCT2 E264K mutation plays a critical role in proliferation in colorectal cancer (CRC), with its overexpression increasing cell growth and knockdown reducing cell proliferation while promoting apoptosis. The findings suggest that SVCT2 E264K could be a promising novel therapeutic target in CRC.
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Le Du, Ning Liu, Jianfeng Jin, Meng Cao, Yuantian Sun, Xinzheng Gao, Banzhan Ruan, Shangfeng Yang, Dongsheng Ge, Yingzhuan Ye, Yinxi Zhou, Erfei Chen, Jin Yang
Summary: Colorectal cancer is a highly prevalent and deadly tumor. This study investigated the role of zinc finger protein 3 (ZNF3) in colorectal cancer and found that ZNF3 is highly expressed in colorectal cancer tissue and cells, particularly in older patients. Overexpression of ZNF3 promotes cell migration, while knockdown of ZNF3 suppresses cell proliferation, migration, and invasion and induces cell cycle arrest. ZNF3 appears to regulate the expression of TWIST and MMP1, which are involved in epithelial-mesenchymal transition, and their overexpression exacerbates cell proliferation and affects cell functions.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Cell Biology
Yang Bai, Ling Li, Zhiyong Zhang
Summary: This study found that Linc00883 plays a promoting role in the proliferation, invasion, and migration of colorectal cancer cells, and this function is achieved through regulating the miR-577/FKBP14 axis.
Article
Biotechnology & Applied Microbiology
Qi-Qi Zhan, Qian-Yu Liu, Xin Yang, Yu-Hui Ge, Lei Xu, Guan-Yi Ding, Shang Guo, Bing Zhu, Wei-Guo Xu
Summary: The silencing of neuropilin-2 (NRP-2) was found to significantly inhibit the proliferation, migration, and invasion abilities of colorectal cancer HT-29 cells.
Article
Biochemistry & Molecular Biology
Weiye Liang, Jia Zuo, Mingkai Liu, Yuling Su, Baoyin Guo, Jiangtao Hou, Qi Xing, Yinglong Peng, Lian Fang, Yihui Cao, Jiajie Shan, Ruixia Sun, Jie Zhao, Jian Wang
Summary: VASN is upregulated in CRC and correlates with tumor progression. Overexpression of VASN promotes CRC cell progression, while knockdown of VASN inhibits CRC progression. VASN interacts with YAP/TAZ and PI3K/AKT pathways, and may serve as a novel biomarker for CRC.
Article
Oncology
Yandong Huang, Qinyang Bai, Zhanlong Wang, Hongbo Yu, Yanru Li, Hao Lu, Huimin Kang, Xuewei Shi, Kai Feng
Summary: This study revealed that circ_0052184 promotes the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis, providing an explanation for the malignant progression of colorectal cancer at the molecular level.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Cell Biology
Rui Bai, Zhong Shi, Dan Li, Donger Zhou, Wei -Ting Ge, Shu Zheng
Summary: This study identifies three genes associated with liver metastasis in colorectal cancer, particularly finding that down-regulation of NKTR gene is associated with lower expression in CRC with liver metastasis. Additionally, interfering with NKTR gene increases the proliferation, migration, and invasion abilities of colorectal cancer cells.
Article
Cell Biology
Rui Bai, Zhong Shi, Dan Li, Donger Zhou, Wei-Ting Ge, Shu Zheng
Summary: This study aims to identify biomarkers for easier detection of liver metastasis in colorectal cancer (CRC). Through microarray analysis and qRT-PCR validation, three genes (MALAT1, NKTR, and NFIB) were found to be significantly differentially expressed between CRC with and without liver metastasis. Further functional experiments demonstrated that down-regulation of NKTR promoted cell proliferation, migration, and invasion in vitro.
Article
Biochemistry & Molecular Biology
Duaa Alkaabi, Kholoud Arafat, Shahrazad Sulaiman, Aya Mudhafar Al-Azawi, Samir Attoub
Summary: Triple-negative breast cancer (TNBC) is a highly aggressive type of breast cancer with poor prognosis. This study investigated the role of programmed death-ligand 1 (PD-L1) in TNBC MDA-MB-231 cells independent of its binding to PD-1 receptors on T cells. The study found that knockout of PD-L1 inhibited cell proliferation, colony formation, migration, and invasion in vitro, as well as tumor growth in a chick embryo model in vivo. PD-L1 knockout also affected the expression of several downstream proteins involved in tumor progression. These findings suggest that targeting PD-L1 could be a potential therapeutic strategy for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Li Zhang, Xingyue Chen, Shun Yao, Liming Zheng, Xingyue Yang, Yongfeng Wang, Xin Li, Enqin Wu, Biguang Tuo
Summary: Chloride, as a major intracellular anion, plays a crucial role in maintaining ion homeostasis, osmotic pressure, and cell volume. Intracellular chloride channel 1 (CLIC1), besides its function as an ion channel, is involved in cell cycle regulation and intracellular oxidation. It has been found that CLIC1 is highly expressed in tumor cells and associated with malignancy and poor prognosis, suggesting its potential role in systemic diseases.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Boyang Fan, Chaojing Zheng, Ning Wang, Zewen Chang, Yunxiao Liu, Chunlin Wang, Jun Xiang, Yangbao Tao, Guiyu Wang, Qian Zhang
Summary: The study identifies a novel circRNA, circSTK3, which is significantly upregulated in colorectal cancer (CRC) tissues and is associated with decreased survival. Functional assays show that circSTK3 promotes cell migration and invasion, and gene expression analysis reveals its involvement in CRC metastasis. The study also uncovers that CTCF transcriptionally regulates circSTK3. These findings highlight the functional and prognostic roles of circSTK3 and demonstrate the importance of circRNAs in metastasis.
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Zhe Cai, Liangyuan Suo, Zeqing Huang
Summary: The study suggests that isoflurane can suppress malignant growth and enhance apoptosis of colorectal cancer cells. MiR-216 is identified as a potential target of isoflurane, which could be utilized for the treatment of colorectal cancer.
FRONTIERS IN MEDICINE
(2021)