Article
Pharmacology & Pharmacy
Sahand Mazloum-Ravasan, Maryam Mohammadi, Elaheh Madadi Hiagh, Alireza Ebrahimi, Joo-Hyun Hong, Hamed Hamishehkar, Ki Hyun Kim
Summary: This study investigated the effects of zein hydrolysate and nano-liposomal zein hydrolysate on human lung cancer cells, and found that nano-liposomal zein hydrolysate exhibited higher cytotoxicity and anticancer effects.
Article
Biochemistry & Molecular Biology
Heying Zhou, Fengxia Li, Yanli Li
Summary: Gedunin, a phytochemical derived from Azadirachta indica, exhibits various pharmacological activities, including anti-tumor and anti-inflammatory effects. The study found that gedunin effectively inhibited the viability of gastric cancer cells, increased the generation of reactive oxygen species, and induced apoptosis, suggesting its potential as a therapeutic agent for gastric cancer.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Haleh Forouhandeh, Vahideh Tarhriz, Masoumeh Zadehkamand, Parina Asgharian
Summary: The cytotoxicity and mortality mechanisms of Artemisia marschalliana essential oil and extracts were investigated in this study. The results showed that the 60% dichloromethane extract exhibited the strongest cytotoxicity on breast cancer cells, while the 80% fraction showed the most cytotoxicity on liposarcoma cancer cells. Flow cytometry analysis confirmed the apoptosis mechanism in killing cancer cells. Additionally, the essential oil of Artemisia marschalliana showed considerable cytotoxic properties.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Biochemistry & Molecular Biology
Han-Lin Hsu, Bo-Jyun Lin, Yu-Chen Lin, Chih-Chieh Tu, Nham-Linh Nguyen, Ching-Chiung Wang, Mei-Chuan Chen, Chun-Han Chen
Summary: This study demonstrates that Cucurbitacin E has potential as a promising drug candidate for NSCLC by inhibiting cell viability and proliferation in EGFR and KRAS mutated NSCLC cells through modulation of cell cycle progression and protein phosphorylation levels.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Gheybi, Fatemeh Rajabian, Zahra Tayarani-Najaran, Amir Reza Adibi, Seyedeh Hoda Alavizadeh, Prashant Kesharwani, Amirhossein Sahebkar
Summary: Silymarin nanoliposomes (SL-L) have a protective effect against cadmium (Cd) toxicity, and the concentration-dependent antioxidant and anti-apoptotic balance is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Haleh Forouhandeh, Zahra Rezaei Param, Ommoleila Molavi, Parina Asgharian, Vahideh Tarhriz
Summary: This study evaluated the anti-proliferative activity of E. caucasicum on melanoma cancer cells and non-cancerous cells. The n-Hexane extract and its 40% and 60% fractions showed the highest cytotoxic effect against the B16F10 cell line, inhibiting growth through induction of apoptosis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Oncology
Mariana Nobre Farias de Franca, Raquel Geralda Isidorio, Joao Henrique Oliveira Bonifacio, Edmilson Willian Propheta dos Santos, Jileno Ferreira Santos, Flaviano Melo Ottoni, Waldecy de Lucca Junior, Ricardo Scher, Ricardo Jose Alves, Cristiane Bani Correa
Summary: The evaluated lawsone derivatives have potential activity on tumor cells, with one compound capable of inducing cell death by apoptosis in melanoma cells.
Article
Biochemistry & Molecular Biology
Adria Hasan, Nizar Khamjan, Mohtashim Lohani, Snober S. Mir
Summary: The dysregulation in apoptotic and autophagic pathways plays a crucial role in the pathophysiology of lung cancer. Understanding the crosstalk between apoptosis and autophagy is important for developing effective cancer therapeutics. This study evaluated the effects of combining metformin and gedunin on A549 lung cancer cells, showing that the combination increased apoptosis by inhibiting the EGFR/PI3K/AKT pathway and autophagy.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Immunology
Hee-Seop Lee, Gillian Tamia, Hee-Jung Song, Darshika Amarakoon, Cheng- Wei, Seong-Ho Lee
Summary: Cannabidiol (CBD) inhibits cell viability, induces cell cycle arrest, and promotes apoptotic cell death in human colorectal cancer cells, while also inducing endoplasmic reticulum stress and regulating protein expression. CBD and its derivatives show potential as promising agents for the prevention of human colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Dorothy Priyanka Dorairaj, Jebiti Haribabu, Yu-Lun Chang, Cesar Echeverria, Sodio C. N. Hsu, Ramasamy Karvembu
Summary: In this study, the synthesis of four new Pd(II) acylthiourea complexes was reported to investigate the impact of halogen substituted acylthiourea ligands on the biological applications of their Pd(II)-PPh3 complexes. The complexes exhibited good binding ability with biomolecules and showed remarkable anti-proliferative activity on cancer cell lines, with complex C2 displaying superior activity against HeLa cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Junchen Tang, Weichao Li, Tzu-Yuan Chiu, Francisco Martinez-Pena, Zengwei Luo, Christine T. Chong, Qijia Wei, Nathalia Gazaniga, Thomas J. West, Yi Yang See, Luke L. Lairson, Christopher G. Parker, Phil S. Baran
Summary: A scalable and concise synthesis of portimines has been successfully achieved, allowing for the structural reassignment of portimine B and in-depth functional evaluation of portimine A. The results demonstrate that portimine A has the ability to selectively induce apoptosis in human cancer cells with high potency and is efficacious in tumor clearance models in vivo.
Article
Biology
Ahmed Al Saqr, El-Sayed Khafagy, Mohammed F. Aldawsari, Khaled Almansour, Amr S. Abu Lila
Summary: Furanodienone (FDN), a bioactive compound derived from Rhizoma Curcumae, has been shown to possess anticancer properties against lung cancer. This study found that FDN inhibits the proliferation of lung cancer cells and induces apoptosis by disrupting nuclear morphology and activating caspase-9 and caspase-3. FDN also induces cell cycle arrest and downregulates the Wnt signaling pathway. These findings suggest that FDN may serve as a promising adjuvant therapy for lung cancer.
Article
Chemistry, Multidisciplinary
Zhangping Xiao, Shanshan Song, Deng Chen, Ronald van Merkerk, Petra E. van Der Wouden, Robbert H. Cool, Wim J. Quax, Gerrit J. Poelarends, Barbro N. Melgert, Frank J. Dekker
Summary: The development of a MIF-targeted PROTAC, MD13, is able to induce MIF degradation at low concentrations and suppress the proliferation of inflammatory and cancer cells, demonstrating the potential therapeutic value of PROTACs in cancer treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Moumita Kundu, Subhayan Das, Suvendu Nandi, Dibakar Dhara, Mahitosh Mandal
Summary: The study found that magnolol (MGN) enhances the therapeutic effect of temozolomide (TMZ) on glioma. MGN promotes glioma cell apoptosis induced by TMZ by inhibiting NF-xB pathway-mediated MGMT activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Pharmacology & Pharmacy
Huan Tang, Zheng Zhang, Ming Zhu, Yizhuo Xie, Zhe Lv, Rui Liu, Yujia Shen, Jin Pei
Summary: The study developed estrone-modified GEM-loaded PEGylated liposomes (ES-SSL-GEM) to improve the targeting ability and therapeutic effect for lung cancer treatment. The results showed that ES-SSL-GEM had a uniform particle size, good stability, and slow release behavior. It significantly inhibited A549 cell proliferation and suppressed tumor growth, indicating its potential application in lung cancer treatment.
Article
Oncology
Varuni Colamba Pathiranage, Jesiska Nirmalee Lowe, Umapriyatharshini Rajagopalan, Meran Keshawa Ediriweera, Kanishka Senathilake, Poorna Piyathilaka, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon
Summary: Resistance to breast cancer treatment is a major clinical issue, and targeting breast cancer stem cells (bCSCs) could be a promising strategy to overcome this challenge. Extracts from Garcinia quaesita fruits show potential anti-cancer and pro-apoptotic properties in bCSCs, making them a possible dietary supplement for breast cancer patients.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Neurosciences
Kristen H. Hutson, Kaitlynn Willis, Chukwumaobim D. Nwokwu, Matthew Maynard, Gergana G. Nestorova
Summary: This study found that radiation caused an increase in mitochondrial mass and oxidative activity, as well as a significant decrease in mitochondrial DNA content. Additionally, the DNA repair protein and clearance of 8-OHdG were also affected. Photon radiation treatment had a more detrimental impact on cells compared to proton treatment.
Article
Oncology
Jeong Yong Moon, Meran Keshawa Ediriweera, Ji Yeon Ryu, Hee Young Kim, Some Kim Cho
Summary: Research indicates that catechol can inhibit proliferation, promote apoptosis, reduce cell migration, invasion, and EMT, and enhance the chemo- and radio-sensitivity of Panc-1 cells by targeting the AMPK/Hippo signaling pathway.
Article
Food Science & Technology
Amal Charindra Hulangamuwa, Meran Keshawa Ediriweera, Umapriyatharshini Rajagopalan, Desiree Nedra Karunaratne, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon
Summary: The study developed a new nanodelivery system comprising of garcinol, hyaluronic acid (HA), and poly(lactic-co-glycolic acid) (PLGA) to target breast cancer stem cells (bCSCs) grown under hypoxic conditions. The HA-coated garcinol-loaded NPs (HA-GA-NPs) showed enhanced antiproliferative effects in bCSCs and improved cellular uptake via receptor-mediated endocytosis, leading to apoptosis. Overall, the findings suggest that HA-GA-NPs can effectively target bCSCs in the hypoxic microenvironment.
JOURNAL OF FOOD QUALITY
(2021)
Article
Nanoscience & Nanotechnology
Gaurav Khandelwal, Meran Keshawa Ediriweera, Neeta Kumari, Nirmal Prashanth Maria Joseph Raj, Somi Kim Cho, Sang-Jae Kim
Summary: The study explores the use of Cu-Asp NFs for TENG, showcasing their stability and performance enhancement through ion deposition. It also demonstrates the development of a self-powered sensor and successful powering of portable electronic devices using NF-TENG.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Hee Young Kim, Meran Keshawa Ediriweera, Kyung-Hwan Boo, Chang Sook Kim, Somi Kim Cho
Summary: The study found that steaming and microwaving increased the total polyphenol content of broccoli florets, while steaming decreased the total flavonoid content and microwaving slightly increased it. All broccoli extracts demonstrated similar radical scavenging and cytoprotective effects. Steamed (3 min)-freeze-dried (F-S3) and microwaved (2 min)-freeze-dried (F-M2) samples showed elevated levels of L-sulforaphane and strong anti-proliferative effects in MCF-7 cells.
Article
Chemistry, Applied
Dennis Kariuki Muthoni, Sameera Ranganath Samarakoon, Poorna Chathurani Piyathilaka, Umapriyatharshini Rajagopalan, Kamani Hemamala Tennekoon, Meran Keshawa Ediriweera
Summary: The study demonstrated that 3-O-L-AO has significant anti-proliferative effects on breast cancer stem cells grown under hypoxic conditions, inducing apoptosis by up-regulating Bax and p53, and down-regulating survivin, HIF-1 alpha, and HIF-2 alpha. This suggests that 3-O-L-AO could be a new anti-cancer agent targeting chemo- and radio-therapy-resistant breast cancer stem cells.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Mohan Singh Rana, Meran Keshawa Ediriweera, Umapriyatharshini Rajagopalan, Desiree Nedra Karunaratne, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon
Summary: A new liposomal nanocarrier, Lipo-Ged-siRNA, was developed to co-deliver gedunin and P-glycoprotein siRNA, aiming to improve the anti-proliferative activity of gedunin. Lipo-Ged-siRNA demonstrated stronger anti-proliferative effects and reduced expression of P-gp, as well as affecting the expression of multiple genes in bCSCs.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Analytical
Chukwumaobim D. Nwokwu, Saif Mohammad Ishraq Bari, K. Hope Hutson, Clay Brausell, Gergana G. Nestorova
Summary: The new exosome sampling technology, ExoPRIME, allows for selective capture of CD63(+) exosome subpopulations under different temperature and incubation conditions. It offers high efficiency capture and flexibility for various experimental needs.
Article
Food Science & Technology
Dae Kyeong Kim, Meran Keshawa Ediriweera, Munkhtugs Davaatseren, Ho Bong Hyun, Somi Kim Cho
Summary: Banana flesh has been found to possess antioxidant and anticancer potential, which can reduce the risk of cancer. Hexane extract (HE) has the highest content of polyphenols and flavonoids in banana flesh, showing strong scavenging activity against free radicals. Moreover, banana flesh extracts exhibit inhibitory effects on cell growth and induce apoptosis in pancreatic cancer and triple-negative breast cancer cells. GC-MS analysis also identifies several anticancer compounds in banana flesh extracts.
FOOD SCIENCE & NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Yen Thi-Kim Nguyen, Ngoc Bao To, Vi Nguyen-Phuong Truong, Hee Young Kim, Meran Keshawa Ediriweera, Yoongho Lim, Somi Kim Cho
Summary: Targeting cancer stem cell metabolism has emerged as a promising therapeutic strategy for cancer treatment. This study explored the glucose metabolism machinery of breast cancer stem cells (BCSCs) and the regulation of glucose metabolism and stemness characteristics by nootkatone. The results showed that BCSCs primarily rely on glycolysis for energy supply and nootkatone impairs glucose metabolism and reduces stemness characteristics through AMPK activation.
Review
Biochemistry & Molecular Biology
Meran Keshawa Ediriweera, Sharmila Jayasena
Summary: Cancer cells reprogram their metabolism to support their growth and survival. Reprogrammed glucose metabolism promotes key characteristics of cancer and enzymes involved in glycolysis can be targeted for anti-cancer treatments. This review summarizes the role of reprogrammed glucose metabolism in cancer cells and discusses its potential for manipulating tumor growth.
Article
Biology
Meran Keshawa Ediriweera
Summary: This study reports for the first time the histone deacetylase (HDAC) inhibitory activity of egg yolks and egg yolk-derived fat from country and farm chickens. The fatty acids in these samples exhibited significant HDAC enzyme activity inhibition and DPPH free radical scavenging effects. Fatty acid analysis revealed varying degrees of saturated, mono-, and polyunsaturated fatty acids in the egg yolks. These findings suggest the potential development of histone deacetylase inhibitors based on egg yolk fat.
Article
Food Science & Technology
Do Manh Cuong, Dae Kyeong Kim, Meran Keshawa Ediriweera, Jong-Eun Park, Jeong Yong Moon, Somi Kim Cho
Summary: This study explores the extraction and drying techniques of Melosira nummuloides and finds that freeze-drying method and chloroform:methanol extraction solvent are effective in extracting products with antioxidant and anti-inflammatory activity.
APPLIED BIOLOGICAL CHEMISTRY
(2023)
Article
Biology
Meran Keshawa Ediriweera
Summary: Irregularities in DNA repair pathways are common in cancer, with POLQ being an overexpressed DNA polymerase in tumor cells. In HR-deficient cells, POLQ-mediated microhomology-mediated end joining (MMEJ) is an important backup repair pathway.
