Review
Biochemistry & Molecular Biology
Najwa Chihaby, Marie Orliaguet, Laetitia Le Pottier, Jacques-Olivier Pers, Sylvie Boisrame
Summary: Mesenchymal stem cells (MSCs) have immunomodulatory properties and show potential for treating Sjogren's syndrome (SS), although the intrinsic mechanism of action remains unclear. Studies have demonstrated improvements in salivary secretions and reduction in lymphocytic infiltration in salivary glands with MSC injections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ji Min Kim, Jeong Hun Kim, Keunyoung Kim, Sung-Chan Shin, Yong-Il Cheon, Hyung Sik Kim, Jin-Choon Lee, Eui-Suk Sung, Minhyung Lee, Gi-Cheol Park, Byung-Joo Lee
Summary: The study found that extracellular vesicles derived from T-MSCs are effective in treating salivary gland dysfunction occurring after menopause, reducing inflammatory cytokine expression and levels of collagen and TGF beta I.
Article
Cell & Tissue Engineering
Charlotte Duch Lynggaard, Christian Gronhoj, Robin Christensen, Anne Fischer-Nielsen, Jacob Melchiors, Lena Specht, Elo Andersen, Jann Mortensen, Peter Oturai, Gry Hoffmann Barfod, Eva Kannik Haastrup, Michael Moller-Hansen, Mandana Haack-Sorensen, Annette Ekblond, Jens Kastrup, Siri Beier Jensen, Christian von Buchwald
Summary: This study aimed to evaluate the safety and efficacy of injecting allogeneic adipose tissue-derived mesenchymal stem/stromal cells (AT-MSCs) into the major salivary glands of patients with head and neck cancer who experienced radiation-induced salivary gland damage. The results showed that this treatment method was safe and effectively improved xerostomia symptoms in patients.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Cell & Tissue Engineering
Zirui Guan, Jiaxin Zhang, Nan Jiang, Mingyan Tian, Hongyong Wang, Bing Liang
Summary: This study aims to assess the quality of evidence for mesenchymal stem cell (MSC) treatment in rodent models of radiation-induced oral complications and determine whether MSCs can improve the therapeutic effect of radiation-induced oral mucositis. The results suggest that MSCs are effective in treating radiation-induced xerostomia and oral mucositis in animal models.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, Research & Experimental
Kathrine Kronberg Jakobsen, Amanda-Louise Fenger Carlander, Christian Gronhoj, Tobias Todsen, Jacob Melchiors, Natasja Paaske, Anne Kathrine ostergaard Madsen, Jens Kastrup, Annette Ekblond, Mandana Haack-Sorensen, Mohammad Farhadi, Christian Maare, Jeppe Friborg, Charlotte Duch Lynggard, Christian von Buchwald
Summary: This is a trial investigating the safety and effectiveness of allogeneic stem cell injection for treating radiation-induced hyposalivation and xerostomia in head and neck cancer patients. The study aims to evaluate changes in saliva flow rate, quality of life, and safety of the treatment.
Review
Biochemistry & Molecular Biology
Lina N. Zaripova, Angela Midgley, Stephen E. Christmas, Michael W. Beresford, Clare Pain, Eileen M. Baildam, Rachel A. Oldershaw
Summary: Mesenchymal stem cells (MSCs) have potential as immunosuppressants for treating autoimmune and autoinflammatory diseases. They can reduce inflammation and promote tissue regeneration. However, during the inflammatory process, MSCs become impaired and lose their immunomodulatory activity. Despite challenges and risks, MSCs show promise in the treatment of severe diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sanshiro Kanazawa, Hiroyuki Okada, Dan Riu, Yo Mabuchi, Chihiro Akazawa, Junichi Iwata, Kazuto Hoshi, Atsuhiko Hikita
Summary: This study demonstrates the important role of c-Mpl signal in the proliferation and differentiation ability of mesenchymal stem cells (MSCs), which are maintained through co-culture with hematopoietic stem cells (HSCs). Furthermore, the study suggests the existence of a hematopoietic-mesenchymal signal and highlights the significance of HSC state in the stability of MSC properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Ajjima Chansaenroj, Supansa Yodmuang, Joao N. Ferreira
Summary: The article discusses the technological advancements and challenges of various cell-based and cell-free strategies in SG tissue engineering and regeneration, emphasizing the use of organoids and secretome produced from stem cells as feasible therapeutic alternatives for SG regeneration.
TISSUE ENGINEERING PART B-REVIEWS
(2021)
Review
Immunology
Peishan Li, Qianmin Ou, Songtao Shi, Changshun Shao
Summary: Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and can be used for the treatment of autoimmune diseases and other chronic disorders. Dental stem cells (DSCs) have remarkable immunomodulatory properties and have therapeutic effects on systemic inflammatory diseases. MSCs derived from nondental tissues, such as the umbilical cord, also show benefits in the management of periodontitis in preclinical studies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Cell Biology
Beverly Brooks, Dominique Ebedes, Ahsan Usmani, Joaquin Vega Gonzales-Portillo, Daniel Gonzales-Portillo, Cesario Borlongan
Summary: Ischemic brain injury is a major cause of death worldwide with limited treatment options. Stem cell-based regenerative therapies, specifically mesenchymal stromal cells, show promise in stroke treatment, but further research is needed to fully understand their cell function.
Review
Cell Biology
Alireza Goodarzi, Mohsen Valikhani, Fatemeh Amiri, Armita Safari
Summary: Mesenchymal stem/stromal cells (MSCs) are characterized by unpredictable characteristics in their bone marrow niche, which makes them an issue in biology. MSCs are widely used in regenerative medicine due to their unique potentials for trans-differentiation, immunomodulation, and paracrine capacity. However, their pathogenic and pro-survival effects in tumors/cancers are undeniable.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Cell Biology
Brandon Nguyen, Tamer Alpagot, Heesoo Oh, David Ojcius, Nan Xiao
Summary: The persistent prevalence of cigarette smoking continues to contribute to preventable disease and death in the United States. There is still much to learn about the impact of cigarette smoke and nicotine on stem cells, particularly in the field of regenerative medicine. Recent studies have focused on the effects of cigarette smoke and nicotine on mesenchymal stem cells, with a specific emphasis on dental stem cells.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kuo-An Chu, Chang-Ching Yeh, Chun-Hsiang Hsu, Chien-Wei Hsu, Fu-Hsien Kuo, Pei-Jiun Tsai, Yu-Show Fu
Summary: This study compared the effectiveness of human umbilical cord Wharton's jelly-derived mesenchymal stem cells (HUMSCs) versus adipose tissue-derived mesenchymal stem cells (ADMSCs) for reversing pulmonary fibrosis in rats. The results showed that HUMSCs had better effects on lung function improvement and collagen degradation, as well as alveolar regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Bowen Hu, Zhanwen Cheng, Shengxian Liang
Summary: This article reviews the effects of nanomaterials on the proliferation and differentiation of various types of stem cells and discusses the advantages of using stem cells in nanotoxicology research.
Article
Multidisciplinary Sciences
Mythreye Venkatesan, Nicholas Zhang, Benoit Marteau, Yukina Yajima, Nerea Ortiz De Zarate Garcia, Zhou Fang, Thomas Hu, Shuangyi Cai, Adam Ford, Harrison Olszewski, Andrew Borst, Ahmet F. Coskun
Summary: Organelles play important roles in human health and disease by maintaining homeostasis, regulating growth and aging, and generating energy. Studying the distribution of organelles at the single-cell level is crucial for understanding cellular function. In this study, rapid multiplexed immunofluorescence (RapMIF) was used to investigate the spatial organization of organelle proteins in mesenchymal stem cells (MSCs) from bone marrow (BM) and umbilical cord (UC). The results showed that UC MSCs exhibited higher organelle expression and spatially spread distribution of mitochondria compared to BM MSCs, providing insights into the interrelations between organelles and the characteristics of MSC subtypes.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Marina Knudsen Kirkegaard, Marthe Minderman, Lene Dissing Sjo, Steven T. Pals, Patrick R. G. Eriksen, Steffen Heegaard
Summary: This study aimed to reclassify ocular adnexal large B-cell lymphomas (OA-LBCLs) and investigate the prevalence and association of MYD88 and CD79B mutations with clinical parameters. The results revealed that OA-LBCL mainly consists of two subtypes, and MYD88 mutations, as well as cMYC/BCL2 double-expressor DLBCL, are associated with poor prognosis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Luc-Matthieu Fornecker, Julien Lazarovici, Igor Aurer, Rene-Olivier Casasnovas, Anne-Claire Gac, Christophe Bonnet, Krimo Bouabdallah, Pierre Feugier, Lena Specht, Lysiane Molina, Mohamed Touati, Cecile Borel, Aspasia Stamatoullas, Emmanuelle Nicolas-Virelizier, Laurent Pascal, Pieternella Lugtenburg, Nicola Di Renzo, Thierry Vander Borght, Alexandra Traverse-Glehen, Peggy Dartigues, Martin Hutchings, Annibale Versari, Michel Meignan, Massimo Federico, Marc Andre
Summary: This study evaluated the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in early-stage unfavorable Hodgkin lymphoma. The results showed that BV-AVD had a higher PET-negative rate compared to ABVD after two cycles. High total metabolic tumor volume was associated with shorter progression-free survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Susanne Irene Scott, Anne Kathrine O. Madsen, Niclas Rubek, Birgitte Wittenborg Charabi, Irene Wessel, Claus Jensen, Jeppe Friborg, Christian von Buchwald
Summary: This study investigated the outcomes of dysphagia and quality of life in patients treated for oropharyngeal cancer with primary trans oral robotic surgery (TORS) or radiotherapy (RT). The results showed significant improvements in swallowing function after 1 to 3 years of treatment, particularly in patients treated with TORS. However, these improvements did not translate into clinically meaningful improvements in quality of life.
Review
Virology
Seyed Keybud Katirachi, Mathias Peter Gronlund, Kathrine Kronberg Jakobsen, Christian Gronhoj, Christian von Buchwald
Summary: This study aimed to determine the prevalence of human papillomavirus (HPV) infection in oral cavity squamous cell carcinomas (OCSCC). A meta-analysis of 31 studies including 5007 patients revealed an overall HPV+ OCSCC prevalence of 6% (95% CI; 3-10%). The results suggest that HPV may not be a necessary or strong risk factor in OCSCC oncogenesis.
Editorial Material
Veterinary Sciences
Annika Linde, John Tegzes, Tonatiuh Melgarejo, Dominique Griffon, Vet Med
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2023)
Article
Oncology
Emmanouil Terzidis, Jeppe Friborg, Ivan R. Vogelius, Giedrius Lelkaitis, Christian von Buchwald, Anders B. Olin, Helle H. Johannesen, Barbara M. Fischer, Irene Wessel, Jacob H. Rasmussen
Summary: This study aimed to evaluate the mismatch between tumor volumes defined from PET/MRI hybrid imaging and pathology, and its potential clinical impact. The results showed a mismatch between imaging and pathological defined tumor volumes in all patients. However, after the addition of a clinical 5 mm margin, the entire pathological volume was fully encompassed in the imaging-defined tumor volume in most patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Respiratory System
Tobias Todsen, Martin G. Tolsgaard, Thomas Benfield, Fredrik Folke, Kathrine K. Jakobsen, Niels Tobias Gredal, Annette K. Ersboll, Christian von Buchwald, Nikolai Kirkby
Summary: This study compared the detection rate of SARS-CoV-2 using nasopharyngeal swab (NPS), oropharyngeal swab (OPS), and saliva specimen collection. The results showed that OPS had the highest detection rate, while saliva sampling had the lowest. OPS sampling had higher detection rate and lower discomfort compared to NPS. Although saliva sampling had the lowest detection rate, it was the least costly.
Editorial Material
Virology
Tina Dalianis, Christian von Buchwald, Anders Nasman, Stina Syrjanen
Review
Oncology
Anne Marie Lindegaard, Katrin Hakansson, Mogens Bernsdorf, Anita B. Gothelf, Claus A. Kristensen, Lena Specht, Ivan R. Vogelius, Jeppe Friborg
Summary: This systematic review examines the clinical and dosimetric benefits of adaptive radiotherapy (ART) in head and neck cancer patients. The results show that ART can effectively reduce doses to organs at risk, but the impact on toxicity and disease control is uncertain. Larger, prospective trials with well-defined control groups are needed to further investigate these findings.
Letter
Oncology
Julie Kjems, Michael R. T. Laursen, Claus A. Kristensen, Anita B. Gothelf, Mogens Bernsdorf, Lena Specht, Anne K. Berthelsen, Ivan R. Vogelius, Gitte F. Persson, Jeppe Friborg
Editorial Material
Otorhinolaryngology
Jacob P. S. Nielsen, Christian von Buchwald, Christian Gronhoj
ACTA OTO-LARYNGOLOGICA
(2023)
Review
Otorhinolaryngology
Theresa Emilia Britze, Kathrine Kronberg Jakobsen, Christian Gronhoj, Christian von Buchwald
Summary: This study reviewed the role of biomarkers in liquid biopsies and saliva samples in monitoring salivary gland cancer. Five studies identified potential biomarkers in blood and saliva samples, and concluded that further research is needed before the method can be used for diagnosis.
ACTA OTO-LARYNGOLOGICA
(2023)
Article
Oncology
Kathrine K. Jakobsen, Simone K. Bendtsen, Niels Pallisgaard, Jeppe Friborg, Giedrius Lelkaitis, Christian Gronhoj, Christian von Buchwald
Summary: This study aims to evaluate the accuracy of cell-free human papillomavirus-DNA (cfHPV-DNA) measurements in liquid biopsies and found a high sensitivity in predicting disease in patients with HPV-positive/p16-positive oropharyngeal squamous cell carcinoma (OPSCC). Serial plasma HPV samples were recommended for clinical monitoring of these patients.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Kathrine Kronberg Jakobsen, Amanda-Louise Fenger Carlander, Christian Gronhoj, Tobias Todsen, Jacob Melchiors, Natasja Paaske, Anne Kathrine ostergaard Madsen, Jens Kastrup, Annette Ekblond, Mandana Haack-Sorensen, Mohammad Farhadi, Christian Maare, Jeppe Friborg, Charlotte Duch Lynggard, Christian von Buchwald
Summary: This is a trial investigating the safety and effectiveness of allogeneic stem cell injection for treating radiation-induced hyposalivation and xerostomia in head and neck cancer patients. The study aims to evaluate changes in saliva flow rate, quality of life, and safety of the treatment.
Article
Oncology
Martin Garset-Zamani, Rikke Norling, Christoffer Holst Hahn, Tina Klitmoller Agander, Christian von Buchwald, Tobias Todsen
Summary: This study demonstrates the potential and feasibility of transoral ultrasound in improving the initial clinical evaluation of patients with suspected oropharyngeal cancers.