期刊
TRENDS IN PARASITOLOGY
卷 33, 期 9, 页码 678-693出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2017.05.004
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资金
- Generalitat Valenciana [PROMETEO2014-083 Fase II]
- Ministerio de Economia y Competitividad [BFU2016-75639-P]
- Red de Investigacion Cooperative en Enfermedades Tropicales - RICET, IV National Programe of I+D+I, ISCIII - Subdireccion General de Redes y Centros de Investigacion Cooperative [RD12/0018/0013]
- FEDER from the Ministerio de Sanidad y Consumo
Intestinal helminthiases affect millions of people worldwide, mainly in developing regions, where they cause a significant negative impact on human health and socioeconomic growth of affected populations. However, intestinal helminthiases are still among the most neglected tropical diseases. Protective immunity against intestinal helminths is associated with development of type 2 responses. Nevertheless, in some host-intestinal helminth combinations, local Th1 responses are initiated, inducing chronicity. The usage of helminth-mouse models is useful for elucidating the mechanisms behind the initiation of each type of response. Herein, the current knowledge on these topics is reviewed, paying particular attention to the earliest events of the immune cascade which eventually lead to either susceptibility or resistance to infection.
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