期刊
TRENDS IN MOLECULAR MEDICINE
卷 23, 期 7, 页码 651-668出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2017.05.001
关键词
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资金
- California Institute of Regenerative Medicine (CIRM) New Faculty Physician Scientist Award [RN3-06378]
- National Institutes of Health (NIH) Director's New Innovator's Award [DP2HL127728]
- Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Center at the University of California, Los Angeles
- Rose Hills Foundation Research Award
Human pluripotent stem cells (hPSCs) offer a practical source for the de novo generation of cardiac tissues and a unique opportunity to investigate cardiovascular lineage commitment. Numerous strategies have focused on the in vitro production of cardiomyocytes, smooth muscle, and endothelium from hPSCs. However, these differentiation protocols often yield undesired cell types. Thus, establishing a set of stage-specific markers for pure cardiac subpopulations will assist in defining the hierarchy of cardiac differentiation, aid in the development of cellular therapy, and facilitate drug screening and disease modeling. The recent characterization of many such markers is enabling the isolation of major cardiac lineages and subpopulations from differentiating hPSCs. We provide here a comprehensive review detailing the suite of biomarkers used to differentiate cardiac lineages from mixed hPSC-derived populations.
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