期刊
TRENDS IN MOLECULAR MEDICINE
卷 23, 期 12, 页码 1088-1102出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2017.10.003
关键词
-
资金
- National Health and Medical Research Council of Australia (NHMRC) [APP1037373]
- NHMRC [APP1100164, APP1098820, APP1098826, APP1100609]
- University of Melbourne [603107]
Bacterial effector proteins are a specialized class of secreted proteins that are translocated directly into the host cytoplasm by bacterial pathogens. Effector proteins have diverse activities and targets, and many mediate post-translational modifications of host proteins. Effector proteins offer potential in novel biotechnological and medical applications as enzymes that may modify human proteins. Here, we discuss the mechanisms used by effectors to subvert the human host through blocking, blunting, or subverting immune mechanisms. This capacity allows bacteria to control host cell function to support pathogen survival, replication and dissemination to other hosts. In addition, we highlight that knowledge of effector protein activity may be used to develop chemical inhibitors as a new approach to treat bacterial infections.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据