Editorial Material
Oncology
Giovanni Fuca, Francesca Corti, Filippo Pietrantonio
Summary: The timing of disease re-assessment may influence the incidence of pseudoprogression, with early assessments being associated with higher incidence. These dynamics should be considered when interpreting the efficacy of treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Sabrina Cappello, Hsu-Min Sung, Christian Ickes, Christine S. Gibhardt, Adina Vultur, Hilal Bhat, Zhongwen Hu, Patricia Brafford, Andreas Denger, Ioana Stejerean-Todoran, Rixa-Mareike Koehn, Verena Lorenz, Nicolas Kuenzel, Gabriela Salinas, Hedwig Stanisz, Tobias Legler, Peter Rehling, Michael P. Schoen, Karl S. Lang, Volkhard Helms, Meenhard Herlyn, Markus Hoth, Carsten Kummerow, Ivan Bogeski
Summary: The study reveals the potential therapeutic benefits of harnessing Natural Killer (NK) cells in melanoma immunotherapy and identifies certain proteins that can affect NK cell-mediated melanoma killing. These findings contribute to the identification of novel prognostic biomarkers related to NK cells and may lead to improved and personalized melanoma-directed immunotherapies.
Letter
Biodiversity Conservation
Mahi Puri, Arjun Srivathsa, Krithi K. Karanth, Imran Patel, N. Samba Kumar
Summary: The study used an occupancy framework to explore leopard occurrence and conflict patterns in a shared forest landscape in central India, as well as the role of wild prey in offsetting livestock depredation. The authors responded in detail to concerns raised by Naha et al., refuting their claims and reiterating the accurate interpretation of their findings.
ECOLOGICAL INDICATORS
(2021)
Article
Environmental Sciences
Yang Deng, Yan Yan, Yiting Wu, Gan Liu, Jie Ma, Xiaoguang Xu, Guoxiang Wang
Summary: This study constructed microcosms to simulate the decomposition processes of aquatic plant residues and invasive algae, finding that the addition of algae promoted the decomposition and produced a positive co-metabolism effect. The response of plant residues to algal organic matter differed, with P. australis showing the highest co-metabolism intensity. As shallow lakes face the double pressure of eutrophication and global warming, the co-metabolism effect of residue decomposition processes should be considered in future lake management.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Forestry
Faizah N. Alenezi, Ali Chenari Bouket, Hafsa Cherif-Silini, Allaoua Silini, Marcel Jaspars, Tomasz Oszako, Lassaad Belbahri
Summary: The Aneurinibacillus migulanus (A. migulanus) strains Nagano and NCTC 7096 have been proven to be powerful biocontrol agents against plant diseases. The cyclic peptide gramicidin S (GS) produced by both strains plays a major role in inhibiting bacteria and fungus-like organisms. A mutant of the Nagano strain impaired in GS biosynthesis showed a total loss of biocontrol ability, highlighting the importance of GS in the biocontrol potential of A. migulanus Nagano strain.
Article
Chemistry, Multidisciplinary
Shuai Hou, Surendra H. Mahadevegowda, Derong Lu, Kaixi Zhang, Mary B. Chan-Park, Hongwei Duan
Summary: Metabolic labeling with Au/MFO Janus nanoparticles allows for precise targeting and thermal killing of Gram-positive bacteria. The nanoparticles are designed to have spatially separated targeting and reporting functions, enabling efficient enrichment and magnetic thermal therapy of labeled bacteria. The delicate design of nanoparticles facilitates simultaneous targeting, detection, and therapeutic functions.
Editorial Material
Geosciences, Multidisciplinary
Colin N. Waters, Martin J. Head, Jan Zalasiewicz, Francine M. G. McCarthy, Scott L. Wing, Peter K. Haff, Mark Williams, Anthony D. Barnosky, Barbara Fialkiewicz-Koziel, Reinhold Leinfelder, J. R. McNeill, Neil L. Rose, Will Steffen, Colin P. Summerhayes, Michael Wagreich, Zhisheng An, Alejandro Cearreta, Andrew B. Cundy, Ian J. Fairchild, Agnieszka Galuszka, Irka Hajdas, Yongming Han, Juliana A. Ivar do Sul, Catherine Jeandel, Jaia Syvitski, Simon D. Turner, Jens Zinke
Summary: Merritts et al. inaccurately portray Paul Crutzen's Anthropocene concept, misinterpreting it as encompassing all significant anthropogenic impacts, extending back many millennia. Waters et al. introduced the concept of a Great Acceleration Event Array (GAEA) which highlights diverse and complex stratigraphic event markers that are tightly clustered around 1950 CE, providing a clearly recognizable Anthropocene chronostratigraphic base. The 'Anthropocene event' proposed by Merritts et al., following Gibbard et al., confuses the transformative human impact of the chronostratigraphic Anthropocene. Waters et al. recognize an evidence-based Anthropogenic Modification Episode that is more explicitly defined than the interpretive interdisciplinary 'Anthropocene event' of Gibbard et al.
EARTH-SCIENCE REVIEWS
(2023)
Article
Geosciences, Multidisciplinary
Dorothy Merritts, Lucy E. Edwards, Erle Ellis, Michael Walker, Stanley Finney, Philip Gibbard, Jacquelyn L. Gill, Mark Maslin, Andrew Bauer, Matthew Edgeworth, William Ruddiman
Summary: In response to the definition of the Anthropocene as a geological event, Waters et al. introduces a set of new terminology for the Anthropocene that has little or no support in the geological literature. They argue that the Anthropocene should be understood as a complex and ongoing event composed of various identifiable events.
EARTH-SCIENCE REVIEWS
(2023)
Letter
Virology
Liyang Zhao, Yusi Li, Wenjuan Yi, Kuo Yan, Chao Yang, Sridhar Radhakrishnan, Rui Li, Ruirong Tan, Gang Fan, Mengyuan Dai, Miao Liu, Ning-Yi Shao
Summary: Although smoking might increase the risk of severe COVID-19, our previous study did not find strong evidence to support this conclusion. We also acknowledged that patients with diabetes or other chronic diseases could have worse outcomes in COVID-19, but this aspect was not investigated in our study as we had published separate research on diabetes. Due to limited sample size and medical records, our study could not encompass multiple factors. Nonetheless, we hope our study serves as a useful and meaningful pilot study for future research.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Hyejin Cho, Atanu Naskar, Sohee Lee, Semi Kim, Kwang-Sun Kim
Summary: A nickel-doped zinc oxide and black phosphorus nanocomposite displayed a strong synergistic effect with polymyxin B against polymyxin-resistant E. coli, neutralizing the charge on the bacterial surface and facilitating the incorporation of polymyxin B. The combination was shown to be biocompatible and has the potential to revive polymyxins as effective antibiotics against resistant Gram-negative bacterial infections.
Article
Meteorology & Atmospheric Sciences
K. H. H. van Diepen, J. Goudriaan, J. Vila-Guerau de Arellano, H. J. de Boer
Summary: This study compared two photosynthesis models (FvCB and G85) and found that despite fundamental differences in model structure, they calculated similar responses of photosynthesis to light and CO2. The results highlight the functional similarities between these two model approaches in photosynthesis.
JOURNAL OF ADVANCES IN MODELING EARTH SYSTEMS
(2022)
Editorial Material
Oncology
Michelle A. Mollica, Wen-Ying Sylvia Chou, Emily S. Tonorezos, Ashley Wilder Smith
Summary: The study highlights the importance of ensuring caregivers have access to trustworthy cancer information. Healthcare providers should work to reduce the impact of misinformation on social media and actively support patients and caregivers in accessing credible cancer information.
Editorial Material
Neurosciences
E. Jolly, S. Sadhukha, L. J. Chang
Summary: Recent studies have shown limited effectiveness of custom-molded headcases in reducing head motion. Comments from other researchers support the original findings and raise potential issues, but overall do not diminish the value of the original work, instead helping researchers make more informed choices in their research protocols.
Editorial Material
Oncology
Raphael Colle, Thierry Andre, Yves Menu
Summary: The article highlights that early tumor shrinkage and depth of response predict prognosis in colorectal cancer patients treated with immune checkpoint inhibitors, but no cases of pseudoprogression were observed. Discrepancies with other studies may be due to differences in radiological evaluation criteria and timing of imaging.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Nina Frey, Luigi Tortola, David Egli, Sharan Janjuha, Tanja Rothgangl, Kim Fabiano Marquart, Franziska Ampenberger, Manfred Kopf, Gerald Schwank
Summary: This study systematically explores the immune evasion mechanisms of pancreatic ductal adenocarcinoma (PDA) and identifies Vps4b and Rnf31 as essential factors for escaping CD8(+) T cell killing. Inactivation of Vps4b impairs autophagy, leading to increased accumulation of granzyme B derived from CD8(+) T cells and subsequent tumor cell lysis. Inactivation of Rnf31 protects tumor cells from TNF-mediated caspase 8 cleavage and apoptosis induction. Transplantation of Vps4b- or Rnf31-deficient pancreatic tumors into immune competent mice shows increased CD8(+) T cell infiltration and effector function, as well as significantly reduced tumor growth.
NATURE COMMUNICATIONS
(2022)
